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김현정 ( Hyun Jung Kim ),정세규 ( Se Kyoo Jeong ),이승헌 ( Seung Hun Lee ) 한국피부장벽학회 2008 한국피부장벽학회지 Vol.10 No.2
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with a complex interplay between multiple factors, such as 1> strong genetic factors 2> the cutaneous hyper-reactivity to environmental trigger 3> neurologic and pharmacologic dysfunction 4> underlying defect in skin barrier function. Various contact allergens and aero allergens are focused as the important factors for the initiation of atopic diseases, aggravation of the diseases and therapeutic targets. In this review, the role of allergens in atopic disease can be explained in the view of various proteases, chitinase, abnormal skin barrier function and finally the vicious relationship with inflammation.
스트론튬 이온이 무모 생쥐의 표피 투과 장벽 회복에 미치는 영향
김현정 ( Hyun Jeong Kim ),김민정 ( Min Jung Kim ),정세규 ( Se Kyoo Jeong ),최기주 ( Ki Ju Choi ),서정택 ( Jeong Taek Seo ),최응호 ( Eung Ho Choi ),안성구 ( Sung Ku Ahn ),이승헌 ( Sung Hun Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
Background: Several ions, such as calcium or magnesium ions, are reported to have regulatory effects on epidermal permeability barrier homeostasis. Recently, it has been suggested that strontium ion can play a substitutive role for calcium ion in various cellular reactions. Objective: This study was conducted to investigate the effects of strontium ion, either alone or in combination with calcium or magnesium ions, on epidermal permeability barrier homeostasis. Methods: Female hairless mice were used to study the effects of various ions on epidermal permeability barrier recovery. Calcium chloride solution, magnesium chloride solution or strontium chloride solution were topically applied to barrier-disrupted skin, either alone or simultaneously. Change of transepidermal water loss, which represents permeability barrier function, was measured by TEWameter and morphological change was also observed by light and electron microscopy. Results: Topical application of strontium chloride solution accelerated permeability barrier recovery rate, compared with vehicle-applied skin. Magnesium chloride solution also accelerated barrier recovery rate, as reported in previous studies. Interestingly, simultaneous application of strontium and calcium ions significantly accelerated barrier recovery rate, compared to application of strontium or calcium ion alone. Nile red staining confirmed the increased neutral lipid deposition in strontium ion applied skin. Electron microscopic observation also revealed an increased lamellar body secretion in strontium ion applied skin. Conclusion: Strontium ion can play a regulatory role in epidermal permeability barrier homeostasis due to, at least in part, its competitive action on calcium ion for the same ion channel. (Korean J Dermatol 2006;44(11):1309~1316)
참느릅나무(Ulmus parvifolia) 잎 추출물 분석 및 안정성 평가
김두영 ( Doo-young Kim ),송수빈 ( Soobin Song ),김일주 ( Iljoo Kim ),정세규 ( Se-kyoo Jeong ),김성우 ( Sungwoo Kim ),김정희 ( Jung-hee Kim ),장현재 ( Hyun-jae Jang ),오세량 ( Sei-ryang Oh ),류형원 ( Hyung Won Ryu ) 한국응용생명화학회(구 한국농화학회) 2020 Journal of Applied Biological Chemistry (J. Appl. Vol.63 No.4
Ulmus parvifolia 잎의 약리학적 지표 성분을 제시하기 위해 간단하고 신뢰할 수 있는 HPLC 분석방법을 개발하였다. 지표 성분들은 NMR 및 UPLC-QTof-MS 분석에 의해 neochlorogenic acid (trans-5-O-caffeoylquinic acid, 5-CQA)과 chlorogenic acid (trans-3-O-caffeoylquinic acid, 3-CQA)로 구조 동정 되었다. HPLC를 이용하여 두개 화합물을 포함한 잎 추출물의 정성/정량 분석 방법을 평가하였다. 잎 30% 에탄올 추출물과 지표성분의 안정성 테스트는 6개월 동안 평가되었다. 그러나 안정성 조사 기간 동안 추출물과 지표 성분들 각각의 함량에 대한 유의한 변화는 관찰되지 않았다. A simple and reliable HPLC method was developed to determine pharmacologically standard marker compounds of Ulmus parvifolia leaves. Standard markers were characterized with neochlorogenic acid (trans-5-O-caffeoylquinic acid, 5-CQA) and chlorogenic acid (trans-3-O-caffeoylquinic acid, 3-CQA) using NMR and UPLC-QTof-MS analysis. A method for qualitative/ quantitative analysis of the leaves extracts were evaluated including two compounds by using HPLC. The stability test of 30% ethanolic extracts of the leaves sample and standard markers have been evaluated for six months. However, no significant changes in the content of the marker compounds of each extract was observed during the time of investigation.