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지구성 운동이 Goto-Kakizaki 쥐 골격근 형태별 GLUT-4, LDH, MCT-1과 COX-4 발현에 미치는 영향
김승석 ( Seung Seok Kim ),강은범 ( Eun Bum Kang ),김범수 ( Bum Su Kim ),임예현 ( Yea Hyun Lim ),엄현섭 ( Hyun Sub Eum ),김철현 ( Chul Hyun Kim ),박준영 ( Joon Young Park ),정명희 ( Myung Hee Jung ),정국현 ( Kuk Hyun Jung ),조인호 한국운동영양학회 2007 Physical Activity and Nutrition (Phys Act Nutr) Vol.11 No.2
Mizatidine의 기니픽 회장에서의 Choline성 작용
장우성,정재경,김창균,정국현,이석용,조태순,Chang, Woo Sung,Chung, Jae Kyung,Kim, Chang Kyun,Jung, Kuk Hyun,Lee, Seok Yong,Cho, Tae Soon 한국임상약학회 1998 한국임상약학회지 Vol.8 No.2
To clarify whether nizatidine, a $H_2$ receptor antagonist, has the cholinergic activity, the effects of nizatidine on the guinea pig ileum and on the acetylcholinesterase in human serum were studied. And, the mechanism of excitatory effect of nizatidine on the cholinergic system in ileum was also studied. Nizatidine caused a concentration-dependent contractile response by the guinea pig ileum. The $EC_{50}\;was\;53\;{\mu}M$ and the maximum response was at $300\;{\mu}M$. Ranitidine also caused a contractile response by the guinea pig ileum, but cimetidine and famotidine did not. The pretreatment with $H_1$ receptor antagonist did not affect the actions of nizatidine on the guinea pig ileum, but the pretreatment with atropine completely blocked them. Nizatidine significantly enhanced the acetylcholine-induced response of the guinea pig ileum, but not the pilocarpine-induced response. Nizatidine did not affect the histamine-induced response of the guinea pig ileum. Nizatidine still exerted the small excitatory effect on the guinea pig ileum pretreated with the high concentration of physostigmine. Nizatidine significantly inhibited the acetylcholinesterase in human serum. These results suggest that nizatidine exerts an excitatory effect on guinea pig ileum which seems to be associated with the cholinergic system, probably through an indirect mechanism, inhibition of acetylcholinesterase and/or increased release of acetylcholine.
현웅조(Ung-Jo Hyun),원용재(Yong-Jae Won),정응기(Eung-Gi Jeong),안억근(Eok-Keun Ahn),이정희(Jeong-Heui Lee),정국현(Kuk-Hyun Jung),박향미(Hyang-Mi Park),전용희(Yong-Hee Jeon),곽지은(Jieun Kwak),성낙식(Nak-Sig Sung),김정천(Jeong-Cheon K 한국육종학회 2021 한국육종학회지 Vol.53 No.2
Alchanmi’, a japonica rice variety, was developed from a cross between ‘Junam’ and ‘Chilbo’ by a rice breeding team at the NationalInstitute of Crop Science and Icheon, Agricultural Technology Center in 2018. The heading date of ‘Alchanmi’ was August 10 in the middleplain area-two days later than that of ‘Hwaseong’. ‘Alchanmi’ had a culm length of 69 cm, 16 cm shorter than that of ‘Hwaseong’, and 103spikelets per panicle. The viviparous germination rate of ‘Alchanmi’ was 24.4%. It showed resistance to blast, bacterial blight (K1, K2, K3race), and stripe virus, but was susceptible to the K3a race of bacterial blight, dwarf and black streak dwarf viruses, and plant hoppers. Themilled rice of this variety exhibited a translucent and medium short grain shape. The cooked rice grains of ‘Alchanmi’ had an excellent palatabilityindex (0.7) and showed lower amylose content (18.6%) than that of ‘Hwaseong’. The grain milling characteristics of ‘Alchanmi’ were betterthan those of ‘Hwaseong’, especially the head rice milling recovery ratio and head rice ratio (96.2%). ‘Alchanmi’ showed 5.83 MT/ha of milledrice productivity at 6 sites under ordinary cultivation (Registration No. 8132).
현웅조(Ung-Jo Hyun),이정희(Jeong-Heui Lee),정응기(Eung-Gi Jeong),장재기(Jae-Ki Chang),정국현(Kuk-Hyun Jung),조영찬(Young-Chan Cho),이점호(Jeom-Ho Lee),원용재(Yong-Jae Won),서정필(Jung-Pil Suh),안억근(Eok-Keun Ahn),정종민(Jong-Min Jeo 한국육종학회 2019 한국육종학회지 Vol.51 No.4
‘Jinhan’, a japonica rice variety, was developed from a cross between ‘Cheolwon68’ (IT218244) and ‘Junghwabyeo’ (IT260473) by the rice breeding team at National Institute of Crop Science in 2015. ‘Cheolwon68’ is early maturing and resistant to blast disease, and ‘Junghwabyeo’ is a cold-tolerant and high-quality variety. The growth duration of ‘Jinhan’ in the paddy field was 116 days in the Northern Central Highland in Korea, which was similar to that of ‘Jinbu’. The culm length of ‘Jinhan’ was 61 cm, which was 10 cm shorter than that of ‘Jinbu’. The panicle of ‘Jinhan’ was composed of 66 spikelets. The viviparous germination rate of ‘Jinhan’ was 33.2%. ‘Jinhan’ showed resistance to blast disease, but was susceptible to stripe virus, dwarf and black-streaked dwarf viruses, and plant hoppers. The milled rice grains of ‘Jinhan’ showed an excellent palatability index (0.23) and lower protein content (5.7%) than that of ‘Jinbu’. The grain milling characteristics of ‘Jinhan’ were similar to those of ‘Jinbu’. ‘Jinhan’ showed a milled rice productivity of 5.43 MT/ha at four sites cultivated in the Northern Central Highland(Registration No. 7318).
안억근(Eok-Keun Ahn),현웅조(Ung-Jo Hyun),정국현(Kuk-Hyun Jung),원용재(Yong-Jae Won),홍하철(Ha-Cheol Hong),박향미(Hyang-Mi Park),장재기(Jae-Ki Chang),이정희(Jeong-Heui Lee),이점호(Jeom-Ho Lee),성낙식(Nak-Sig Sung),서정필(Jung-Pil Suh) 한국육종학회 2021 한국육종학회지 Vol.53 No.4
‘Keunpum’ is a mid-late maturing, high yielding, giant embryo rice (Oryza sativa L.) cultivar which is adapted to central plainsand was developed to be used as (germinated) brown rice. It is resistant to multiple diseases with a good grain quality. This cultivar wasderived by crossing a giant embryo rice variety ‘Keunnun’ and a mid-late maturing, multi-disease resistant rice cultivar ‘Samkwang’-it hasgood palatability of cooked rice. The growth period of this cultivar is approximately 117 d from seeding to heading, with a culm lengthof 88 ㎝, panicle length of 20 ㎝, 13 panicles per hill, 136 spikelets per panicle, and 1,000-grain weight of 19.1 g brown rice. This varietyhas low tolerance to cold stress and premature germination similar to ‘Keunnun’ but exhibits high resistance to lodging. In addition, ‘Keunpum’is resistant to bacterial blight (race K1, K2, K3), rice stripe virus, and is moderately resistant to leaf and neck blast. Its average milled riceyield for three years reached 5.34 MT/ha, which is 10% higher than that of ‘Keunnun’. In the brown and germinated brown rice of thiscultivar, the total dietary fiber content are 6.45% and 6.71%, and the GABA (γ-amino butyric acid) content are 6.61 and 39.47 mg/100g, respectively. In addition, the total contents of polyphenol, flavonoid, and tannin were higher in ‘Keunpum’ brown rice than in ‘Keunnun’. The DPPH and ABTS radical scavenging activities were 75.23, 116.08 mg TE/100g, respectively. These functional components and antioxidantactivities play an important role in inhibiting diseases and the aging process of the human body. Therefore, it is expected to be used asa basic data in the manufacture of secondary processed products using germinated brown rice (Grant No. 7684).
정진호 ( Jin Ho Chung ),오승종 ( Seung Jong Oh ),정국현 ( Kuk Hyun Jung ),황윤선 ( Yoon Sun Hwang ),최민규 ( Min Gew Choi ),노재형 ( Jae Hyung Noh ),손태성 ( Tae Sung Sohn ),배재문 ( Jae Moon Bae ),김성 ( Sung Kim ),최성희 ( Seon 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2
목적: 본원에서 진단된 위 유암종의 임상병리학적 특성과 치료방법 및 예후에 대해 분석하였다. 방법: 1997년 1월 1일부터 2009년 12월 31일 까지 본원에서 병리조직검사 결과 위의 유암종으로 진단 및 치료 받은 52명의 환자를 대상으로 Rindi 분류에 따라 진단, 치료, 및 경과에 대해 후 향적 연구를 통해 분석하였다. 결과: 남자가 29명, 여자가 23명 (1.26:1) 이었고 평균나이는 54.6세이고 평균추적관찰 기간은 36개월이었다. 그 중 1형은 45 예로 40예(88.9%)에서 단일결절이며 만성위축성위염과 동반된 소견을 보였다. 2형은 2예로 복합내분비신생물 1형 증후군과 병발하였다. 3형은 5예로 모두 T2 이상의 병변이었다. 이들 환자중 절제가 가능한 49예중 12예에서 수술이 시행되었으며 37예에서 내시경적 용종절제술 및 점막하 절제술이 시행되었다. 52명중 3명이 사망하였고 1명이 유암종으로 인한 사망이었다. 결론: Rindi 분류를 통한 국내의 위 유암종은 악성빈혈이 동반되지 않았으며 남성이 더 많이 발생하며 단일결절이 많아 외국의 보고와는 다른 특징을 보였다. Purpose: We analyzed the clinicopathologic characteristics of patients with gastric carcinoid tumor, which is a rare gastric tumor Methods: We reviewed 52 carcinoid patients who were treated from 1997 to 2009. Carcinoids were classified as 3 types along the Rindi et al. The clinicopathologic characteristics, the treatment modalities were retrospectively analysed. Results: There were 29 man, and 28 woman patients.(1.26:1) The mean age of onset was 54.6 years. The average follow up period was 36 months. There were 40 of 45 type I patients who had solitary lesion and all of 45 patients combined with chronic atrophic gastritis. There were 2 type II paitents who combined with Multiple Endocrine Neoplasm type-1. There were 5 type III patients who had above T2 lesions. In the 49 patients who can resection, 12 underwent surgery, and 37 underwent endoscopic polypectomy and submucosal dissection. 3 of 52 patients death and only 1 case were death by disease. Conclusion: Higher incidence of gastric carcinoid tumor with man, less multiplicity, and no concurrence of pernicious anemia were identified in our study compared with previous reports.
안억근(Eok-Keun Ahn),원용재(Yong-Jae Won),홍하철(Ha-Cheol Hong),박향미(Hyang-Mi Park),정국현(Kuk-Hyun Jung),현웅조(Ung-Jo Hyun),장재기(Jae-Ki Chang),이정희(Jeong-Heui Lee),이점호(Jeom-Ho Lee),서정필(Jung-Pil Suh) 한국육종학회 2022 한국육종학회지 Vol.54 No.2
‘Miwoo’ is a mid-late maturing, high-biomass-yielding rice (Oryza sativa L.) cultivar with high feed value and resistance to multiple diseases and insect pests. It was developed for use as whole crop silage (WCS) from a cross between ‘Suweon519’, a line with high biomass yield and multiple disease resistance, and ‘Suweon518’, a medium flowering, high yielding Tong-il type line, which is resistant to blast (BL), bacterial blight (BB) (race K1), rice stripe virus (RSV) and brown planthopper (BPH). In the central plain region of Suwon, ‘Miwoo’ cultivar exhibited a growth period of approximately 122 days from seeding to heading, culm length of 99 cm, panicle length of 28 cm, 12 panicles per hill, 143 spikelets per panicle, and 1,000-grain weight of 25.9 g as brown rice. This mid-late-flowering rice variety was resistant to lodging during the yellowing ripening stage, an optimal period for harvesting. In addition, ‘Miwoo’ was strongly resistant to leaf and neck blast, BB (race K1, K2, K3, K3a), RSV, BPH and small BPH. Its average dry matter yield over 3 years reached 19.9 MT/ha, which is 36% higher than that of ‘Nokyang’. ‘Miwoo’ is a high-amylose cultivar with 70.7% total digestible nutrients (similar to that of Nokyang) and grows well on the central and southern plains of the Korean Peninsula. It should be harvested 30 days after heading to improve its feed value and digestion rate in livestock. (Registration No. 7683)
김명기(Myeong-Ki Kim),신영섭(Young-Seop Shin),원용재(Yong-Jae Won),안억근(Eok-Keun Ahn),서정필(Jung-Pil Suh),정국현(Kuk-Hyun Jung),이점호(Jeom-Ho Lee),전용희(Yong-Hee Jeon),윤영환(Young-Hwan Yoon),윤광섭(Kwang-Sup Yoon),장재기(Jae-Ki 한국육종학회 2015 한국육종학회지 Vol.47 No.2
There are farmer’s demands to develop early-maturing cultivar in order to replace Odae variety to mid-northern inland plain and southern mountainous area of Korea. Saeodae was developed by the rice breeding team of Cheolwon Substation, National Institute of Crop Science (NICS), RDA in 2012. This cultivar was derived from the cross between Geuroobyeo and Suweon 472 in 2001 summer season, and selected by a promising line, SR27376-2-2-1-3, was selected and designated as the line of Cheolweon 81 in 2010. The local adaptability test of Cheolweon 81 was carried out at four locations from 2010 to 2012 and it was named as Saeodae. The heading date of Saeodae is July 25 in Cheolwon area, which is 2 days earlier than that of Odae. This variety has 66cm in culm length and 77 spikelets per panicle. Its 1,000 grain-weight of brown rice is 26.5 g, which is similar to that of Odae. Germination rate at low temperature of this variety is about 70%, and viviparous germination is 17.7%. Cold tolerance of this cultivar is still not good, just mediocre. It shows strong lodging resistance. And premature heading, occurrence of wilting during ripening stage, and leaf senescence at maturing are similar to those of Odae. This variety shows resistance to leaf blast disease, but susceptible to bacterial blight, virus disease and insect pest. This variety has translucent and clear milled rice kernel without white core and belly rice. The yield potential of Saeodae was about 5.26 MT/ha at ordinary fertilizer level in local adaptability test for three years. This variety would be adaptable to mid-northern inland plain and southern mountainous area of Korea.
안억근(Eok Keun Ahn),이상복(Sang Bok Lee),원용재(Yong Jae Won),이점호(Jeom Ho Lee),장재기(Jae Ki Chang),정응기(Eung Gi Jeong),정국현(Kuk Hyun Jung),이정희(Jeong Heui Lee),조영찬(Young chan Cho),정종민(Jong Min Jeong),서정필(Jung Pil 한국육종학회 2018 한국육종학회지 Vol.50 No.3
‘Yeongwoo’, a mid-late flowering, high dry matter yielding rice (Oryza sativa L.) cultivar with high feed value and multiple disease-insect resistance, was developed for whole crop silage (WCS) use. It was derived from a cross between a high biomass and brown planthopper (Bph) resistant ‘SR25848-C99-1-2-1’ and high yielding Tong-il type, ‘Yongmun’ which had diseases resistance. This cultivar had about 117 days growth period from seeding to heading, 99 cm culm length, 26 cm panicle length, 11 panicles per hill, 125 spikelets per panicle, and 1,000-grain weight of 23.6 g as brown rice in the central plain region, Suwon. This wide and long leafy WCS rice variety was weak to cold stresses, similarly to ‘Nokyang’ but was resistant to lodging in the field, strong to viviparous germination, and good under low temperature germination. In addition, ‘Yeongwoo’ was resistant to leaf and neck blast, bacterial blight (race K1, K2, K3, K3a), rice stripe virus, Bph, and small Bph. Its average dry matter yield for three years reached 20.0 MT/ha, 32% higher than that of ‘Nokyang’. This cultivar had 5.3% crude protein and 71.7% total digestible nutrients, which was slightly lower than that of ‘Nokyang’. In the Korean peninsula, ‘Yeongwoo’ grew well in the central and southern plain and was could be harvested between 15 to 30 days after heading to improve the feeding value and digestion rate of livestock (Grant No. 6800).
송유천(You-Chun Song),이종희(Jong-Hee Lee),이지윤(Ji-Yoon Lee),김춘송(Choon-Song Kim),김세리(Se-Ri Kim),정국현(Kuk-Hyun Jung),박노봉(No-Bong Park),곽도연(Do-Yeon Kwak),하운구(Woon-Goo Ha),이점식(Jeom-Sig Lee),강항원(Hang-Won Kang),조준 한국육종학회 2015 한국육종학회지 Vol.47 No.4
‘Danmi’, a sugary rice (Oryza sativa L.), was developed by the Department of Functional Crops, NICS, RDA in 2008. This variety was derived from a cross between ‘Sugary’ a genetic stock of germplasm as a source of sugary endosperm and ‘Seomjinbyeo’ in summer of 1994. The pedigree of ‘Danmi’ is YR16541-14-3-1-2-1-1-3-1-1 which was designated as ‘Milyang 227’ in 2005. Heading date of ‘Danmi’ is August 19, a medium-late maturing ecotype. The total sugar content of ‘Danmi’ was 21.7% with fructose (1.16%), glucose (7.87%), sucrose (9.69%), maltose (0.52%), and raffinose (2.13%), respectively. The appearance of grain is flat shape with 1,000 grain of brown rice is 16.1g. The yield potential of ‘Danmi’ in brown rice is 2.58MT/ha at ordinary fertilizer level of local adaptability test from 2006 to 2008. The sugary rice ‘Danmi’ would be adaptable to the plain paddy field of middle, honam and yeongnam province of Korea.