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Structural analysis of activity-modulating mutations of DUSP19
전태진,남경태,류성언 한국구조생물학회 2015 Biodesign Vol.3 No.2
The activity of cellular signaling proteins modulates cellular processes such as cell growth, immune responses, andneuronal development. Dual specificity phosphatases (DUSPs), which constitute a subfamily of protein tyrosinephosphatases (PTPs), are potential targets for therapeutic development. Recently, allosteric inhibitors of PTPs have shownpromising results with regard to their potency, selectivity and membrane permeability. However, detailed understanding ofthe activity regulation of PTPs is limited. Thus, we determined crystal structures of activity-modulating mutants of DUSP19for which strongly-diffracting crystals are available. One allosteric residue (Ile 187) and two active site residues (Ser 150and Arg 156) were mutated to alanine. High-resolution crystal structure determination and enzyme kinetics analysis of thethree mutants revealed that the mutations resulted in rearrangements in allosteric and local structures. In particular, cavityfillingrearrangements in the I187A mutant were conveyed to the active site, leading to allosteric regulation of enzymeactivity.
전태진,홍창권,노병인 ( Tae Jin Chun,Chang Kwun Hong,Byung In Ro ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6
N/A The authors performed a clinical study of 255 patients with εlopecia areata retrospecitively in order to evaluate the clinical manifestation and the effect of treatment with intralesional injection of triamcinolone acetonide suspension from August, 1986 to February, 1991. The results were as follows : 1. The age distribution showed a peak incidence in the third decade(15.5%, 116/255) and average age was 29.6 years. 2. The most common site of involvement was the occipital region(54.1%) in males and the temporal region(51.0%) in females. 3. The effect of treatment in the group treated with intralesional injection of triamcinolone acetonide revealed no significant difference from the group treated with intralesional injection of tramcinolone acetonide and topical application of minoxidil solutior. 4. The area of the bald patch revealed statistically significant correlation with effect of treatment. But the other factors such as sex, age, history of pervious episode, duration and number of lesions were not contributory. These findings suggested that alopecia areata predominantly developed in male and showed excellent therapeutic effect in cases of bald areas less than 5㎠
전태진,김명남,송계용,노병인 ( Tae Jin Chun,Myeung Nam Kim,Kye Yong Song,Byung In Ro ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5
Verrucous hemangioma is a variant of a capillary, carvernous, or mixed hemangioma which undergoes a reactive proliferative epidermal change. We report two cases which showed clinical and histopathologic findings of verrucous hemangioma. In both cases, reddish hemangiomatous lesions were present since birth and were verrucous crusty lesions of the right lower extremity. Skin biopsy revealed hyperkeratosis, acanthosis, and papilomatosis of the epidermis and proliferation and dilatation of capillaries in the upper dermis in addition to the capillary hemangioma in the deep dermis and subcutis.