Relationship Between Placental Infacrt And Umbilical Venous Erythropoietin And Gas Values

전선희 ( Sun Hee Chun ),( Hae Soo Koo ) 대한산부인과학회 1999 대한산부인과학회 학술대회 Vol.84 No.-

만삭의 정상체중아와 저체중아에서 제대정맥혈 적혈구조혈인자 농도의 비교

전선희(Sun Hee Chun),박미혜(Mi Hye Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

Objective : To evaluate the intrauterine hypoxic effect in term small-for-date (SGA) neonates by comparing the umbilical venous erythropoietin (EPO) concentration between appropriately-grown (AGA) and SGA neonates at delivery and to determine the variables that correlate with the umbilical venous EPO concentration by multiple regression analysis. Methods : 183 term singleton neonates (gestational weeks ≥37) were enrolled and divided into 136 cases of AGA (10th-90th percentile of birth weight for the gestational age) and 47 cases of SGA (< 10th percentile of birth weight for the gestational age. At each delivery, blood gas values, concentration of EPO by radioimmunoassay and the number of nucleated erythrocytes (NRBC) per 100 white blood cells in smear of umbilical venous blood were obtained. The placentas were examined microscopically for presence of pathological infarct. Statistical analysis was done by Mann-Whitney U test, x2 test, and univariate and multiple regression analysis using SPSS statistical package (version 10). Results : The median umbilical venous EPO concentration, fetal hemoglobin level were significantly higher in SGA neonates than those in AGA neonates. There was no difference in number of NRBC between AGA and SGA neonates. Multiple regression analysis model with level of NRBC, presence of placental infarct and SGA provided prediction of EPO level in umbilical venous blood at delivery (regression equation: EPO=-103.94+4.75NRBC+68.07placental infarct+36.40SGA F=15.57. R2=0.47). Conclusion : Term SGA neonates was considered to have compensatory, not pathological intrauterine hypoxic effect by showing increased level of EPO and normal level of NRBC in umbilical venous blood at delivery, compared with thoses of AGA. In the suspected cases of SGA antenatally, measurement of NRBC level and placental pathologic examination for infarct can be informative for estimating the extent and duration of intrauterine hypoxia.

태반경색과 제대정맥혈의 적혈구조혈인자 및 가스분석치와의 관계

전선희(Sun Hee Chun),구혜수(Hae Soo Koo) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

Objective : To investigate the effect of placental infarct on the biochemical markers of intrauterine hypoxia such as erythropoietin(EPO), nucleated erythrocytes(NRBC) and gas values of umbilical cord blood.Methods : Fifty three pregnant women(29-42 gestational weeks) were enrolled and divided into 30 cases of placenal infarct(group I) and 23 cases of normal placental finding(group II). At each delivery, blood gas values, concentration of EPO by radioimmunoassay and the number of NRBC per 100 white blood cells(wbc) in smear of umbilical venous blood were obtained. The placentas were examined microscopically for the presence of pathologic infarct. Statistical ananlysis was done by Mann-Whitney U test and Fisher's exact test. Results : There was no significant difference between group I and group II in umbilical venous median level of EPO (29.5 : 21.9 mIU/mL) and blood gas values including pH, pCO2, pO2 and base deficit. The median number of NRBC in group I was significantly higher than those in group II ( 4.0 : 2.0 /100wbc). The mean birth weight of group I was significantly less than those of group II (2621±760 : 3138±549, p=0.016). The number of neonates that showed one minute Apgar score≤7 were greater in group I than group II, but placental infarct showed no association with fetal distress, acidosis and SGA. Conclusions : Placental infarct showed no effects on level of EPO and measurements of blood gases in umbilical venous blood, but showed effect on number of NRBC and showed association with birth weight and lower Apgar scores of neonates, suggesting that placental infarct affects fetal growth and fetal ability to overcome the hypoxic stress of labor adversely by providing suboptimal intrauterine condition.

일반연제 발표 : 태반에서 Adhesion Molecule에 대한 연구 1: 영양모세포에서 면역세포화학과 reverse transcriptase 중합효소연쇄반응에 의한 alpha1 Integrin subunit의 표현

전선희 ( Sun Hee Chun ) 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.73 No.-

제대정맥혈에서 적혈구조혈인자 및 유핵적혈구와 가스분석치와의 관계

전선희(Sun Hee Chun) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12

Objective: To assess the correlation of erythropoietin(EPO) levels and number of nucleated erythrocytes(NRBC) with measurements of blood gases and to investigate the obstetrical factors influencing the levels of EPO and number of NRBC in umbilical venous blood of non asphyxiated neonates. Methods: Measurements of EPO levels by RIA, number of NRBC per 100 white blood cells(WBC) by blood smear and measurement blood gases were performed at delivery in umbilical venous blood from 117 cases of neonates with gestational age ranged from 29 to 42 weeks, including 77 cases of non-asphyxia and 40 cases of asphyxia. Statistcial analysis included Student's t test, linear regression and linear correlation using SPSS 7.0 version statistical package. Results: The umbilical venous EPO level is correlated significantly with the number of NRBC (r2 =0.204, p<0.05). The level of EPO as well as the number of NRBC showed inverse correlation with umbilical venous pH(r=-0.223, p<0.05 ; r=-0.896, p<0.05). Number of NRBC showed correlation with pCO2 (r=0.700, p<0.01) and base deficit (r=0.316, p<0.01). The mean level of EPO in non-asphyxiated neonates was 26.2 ±16.1 mIU/mL showing correlation with gestational age and birth weight and higher level in neonates delivered vaginally than those delivered by elective cesarean section (27.1±17.0 vs 18.8±6.7 mIU/mL, p=0.012). The mean number of NRBC in non-asphyxiated neonates was 2.5±2.1/100 wbc showing no difference according to mode of delivery, gestational age and birth weight. Conclusion : Number of NRBC not only correlated with cord gas parameters more strongly but also was less influenced by the obstetrical factors than EPO level.

제 73 차 춘계학술대회 : 일반연제발표 ; 태반에서 Adhesion Molecule 에 대한 연구

전선희(Sun Hee Chun) 대한산부인과학회 1993 춘계학술대회 Vol.- No.-

조산의 정상체중아와 저체중아에서 제대정맥혈의 적혈구조혈인자 및 유핵적혈구치의 비교

전선희 ( Sun Hee Chun ),박미혜 ( Mi Hye Park ),김영주 ( Young Ju Kim ),정경아 ( Kung Ah Jeong ),이경아 ( Kyung A Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.5

Objective: To evaluate any difference in levels of umbilical venous eryhthropoietin (EPO) and nucleated red blood cells (NRBC) between appropriate for gestational age (AGA) and small for gestational age (SGA) preterm neonates at birth and to evaluate the peripartal factors that influence the secretion of the nucleated red blood cells in preterm neonate. Methods: 43 preterm singleton neonates born at the gestational age between 27 weeks and 37 weeks of gestation from January 1998 to December 2004 were enrolled and divided into 25 cases of AGA and 18 cases of SGA. At each delivery, umbilical venous blood gas values, concentration of EPO by radioimmunoassay and the NRBC count expressed per 100 white blood cell (WBC) were obtained. The placenta were examined microscopically for the presence of pathologic infarct and inflammation. Statistical analysis was done by Mann-Whitney U test, Fisher exact test, univariate and multiple regression analysis using SPSS statistical package. Results: The median umbilical venous EPO concentration and fetal hemoglobin level in SGA preterm neonates were 48.0 mIU/mL and 15.7 g/dL, which were significantly higher than those in AGA preterm neonates (12.5 mIU/ML, 14.6 g/dL). The median NRBC in SGA group was 8.0 NRBC/100 WBC which was higher than in the AGA group (2.5 NRBC/100 WBC), showing no significant difference between groups. Stepwise multiple regression analysis identified O2 saturation, emergency cesarian section, infarct and inflammation in placental pathology and premature rupture of membranes as independent variables associated with the NRBC count. Conclusion: Measurement of the level of EPO and NRBC in umbilical venous blood at birth of the preterm neonates can be used as a helpful index for evaluation of intrauterine hypoxia. In addition, cord blood gas ananlysis and placental examination on the infarct and inflammation are informative value for the elevated NRBC.

생식기 감염 여성의 자궁경부 검체에서 중합효소연쇄반응에 의한 Chlamydia trachomatis 진단

전선희(Sun Hee Chun) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

Objective: To evaluate the diagnostic value of polymerase chain reaction (PCR) as opposed to Enzyme immunoassay (EIA) of Chlamydia trachomatis in cervices of women with genital tract infection. Methods: Sixty three samples (60 cervical samples and 3 pelvic abscess samples) from sixty women with genital tract infection or lesions such as vaginits, cervicitis, cervical intraepithelial neoplasm (CIN), condyloma accuminata, tuboovarian abscess, preterm labor and premature repture of membranes were tested for Chlamydia trachomatis with PCR and EIA simultaneously. The primers for PCR were for 478 base pairs encoding Chlamydia cryptic plasmid gene Results: Six cases (seven samples) (10%) out of 60 women were positive on PCR while one case (1.7%) was positive on EIA among these women. The positive rate of PCR Chlamydia test according to the diagnosis was as followings; 3 out of 19 cases (15.8%) of cervicitis, 2 out of 5 cases (40%) of CIN, 1 out of 3 cases (33.3%), ol tuboovarian abscess and 1 out of 7 cases (14,3%) of preterm premature rupture of membranes showed positive Chlamydia test. Conclusions: Diagnostic testing of Chlamydia using PCR showed more sensitive for detection of Chlamydia trachomatis compared with EIA in women with genital tract infection. So Chlamydia PCR test is suggested to be valuable in appropriate treatment and prevention of Chlamydia infection especially in women with cervical lesions and pelvic inflammatory disease.

Correlations of Umbilical Venous Erythropoietin and Nucleated Erythrocytes With Blood Gases

전선희 ( Sun Hee Chun ) 대한산부인과학회 1998 대한산부인과학회 학술대회 Vol.82 No.-

폐경전 자궁적출술을 시행받은 여성과 자연폐경 여성에서 에스트로겐 단독투여와에스트로겐+프로게스틴의 지속적 병합투여시 지질 및 고밀도의 변화에 대한 연구

김희옥(Hee Ok Kim),유민영(Min Young Yoo),김연정(Youn Jung Kim),박지은(Ji Eun Park),양훈진(Hoon Jin Yang),유은희(Eun Hee Yoo),전선희(Sun Hee Chun),김종일(Chong Il Kim),유한기(Han Ki Yu) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

Objective : Our purpose was to investigate the effect of single estrogen and continuous combined estrogen + progestin on lipid profile and bone mineral density.Method : We have treated two groups of menopausal women for 4 years, ; Group 1(hysterectomised women) received conjugated equine estrogen(CEE) 0.625mg per day for 30 days ; Group 2(natural menopausal women) received continuous combined therapy(CEE 0.625mg and MPA 2.5mg per day) for 30 days.We compared pre-and poststudy serum lipid profile and bone mineral density in two groups.Result : The data demonstrated a beneficial effect in lipoprotein profile that total cholestrol decreased in two groups by 9.9% and 10.8% from the baseline values. Low density lipoproten(LDL)-cholesterol decreased in two groups by 20.1% and 16.3% in post HRT 48 months, high density lipoproten(HDL)-cholesterol increased in two groups by 21% and 31.9%. And HRT shows the beneficial effect in bone mineral densities. Lumbar BMD increased in two groups by 11.6% and 14.9% and femur BMD increased in two groups by 12.9% and 14.9% from the baseline value.Conclusion : Our result suggest that single estrogen therapy and continuous combined estrogen-progestin therapy has beneficial effect on cardiovascular disease and osteoporosis. Their effects were not significantly different among two groups. So we suggest that continuous combined estrogen-progestin therapy is preferable to single estrogen therapy.