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장주왕,Eric B. Richardson,박선후,이승범 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.4
Liver transplantation has been regarded as the definitive curative approach for pathologic liver conditions from the acute stage to the chronic end stage for decades. Recently, translational research has been focused on liver stem cell transplantation, using various cell therapies, due to the potential benefit of natural host liver regeneration. Many studies are ongoing utilizing and evaluating the use of either fetal-liver-derived stem cells or oval cells, however many obstacles still remain. Extensive research identifying and characterizimg stem/progenitor cells for potential application to in vitro cell therapy, whereas many questions remain concerning the isolation and identification of adult liver stem cells with adequate capacity for proliferation and the regeneration of injured liver. Recent approaches to liver regeneration include the production of hepatocyte-like cells from other stem cell sources such as mesenchymal stem cells and embryonic stems cells. Another major target for liver regeneration studies include the generation of liver stem cells from induced pluripotent stem cells (IPSC) We review the current data concerning characterization of stem cells and progenitor cells for their capacity to support their potential for re-population and regeneration of normal adult liver from liver damaged due to injury and/or disease.
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Association between Hospital Visits for Superficial Fungal Infections and Climatological Factor
서현민,박세광,오세욱,장주왕,김정수 대한의진균학회 2020 대한의진균학회지 Vol.25 No.2
Background: No cohort studies exist on the effect of temperature and humidity on the number of visits to hospitals by patients with superficial fungal infections. Objective: The aim of our study was to investigate the relationship between climatological factors and superficial fungal infection-related hospital visits. Methods: This study was a retrospective cohort study based on the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database of patients with superficial fungal infection, from 2003 to 2012. We analyzed epidemiological characteristics and types of superficial fungal infection using descriptive statistics. We extracted climatological variables including temperature, relative humidity, precipitation, wind speed, possible duration of sunshine, and duration of sunshine from the Korea Meteorological Administration. Results: 116,903 patients presented with superficial fungal infections in the NHIS-NSC database. The most common type of superficial fungal infection-related hospital visits was tinea unguium (46.72%), followed by tinea pedis (28.38%), tinea corporis (9.19%), and tinea cruris (7.52%). Significant positive linear associations were found between mean daily superficial fungal infection-related hospital visits and daily average temperature (p < 0.001) and relative humidity (p < 0.001). Conclusion: The data from this study indicated that high temperature and high relative humidity may exacerbate superficial fungal infections.
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