파킨슨병과 진행성 핵상마비에서의$^1H$자기공명분광법:예비 연구

장기현,전범석,송인찬,김동성,민관홍,한문희,강사욱,민병구,한만청 대한영상의학회 1996 대한영상의학회지 Vol.34 No.6

Purpose : To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiatingidiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios.Materials and Methods : Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions ofinterest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. Results : NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 $\pm$ 0.26 versus 1.45 $\pm$ 0.20, and 1.26 $\pm$0.23 versus 1.38 $\pm$ 0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 $\pm$ 0.21 versus 1.76 $\pm$ 0.15, and 1.36 $\pm$ 0.13 versus1.79 $\pm$ 0.17, respectively : p<0.05). However, NAA/Cho and NAA/Cr ratios between age-matched controls and IPD werenot significantly different (p>0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. Conclusion : NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSPgroup than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differentialdiagnosis of IPD and PSP.

터키안 및 그 주위종양의 전산화단층촬영 소견

장기현 대한영상의학회 1980 대한영상의학회지 Vol.16 No.2

A total of 42 cases of sellar and parasellar tumors are verified at Seoul National University Hospital from December 1978 through July 1980. They are composed of 25 pituitary adenomas, 5 meningiomas, 4 craniopharyngiomas, 1 astrocytoma, 1 germinoma, 1 teratoma, 1 epidermoid, 1 arachnoid cyst, 1 chondroma, 1 sphenoid mucocele and 1 chronic epidural hematoma. Authors analyzed and described the computed tomographic findings of them.

뇌경막외 및 뇌경막하혈종의 방사선학적 고찰

장기현 대한영상의학회 1975 대한영상의학회지 Vol.11 No.2

It is recognized that the differential diagnosis between an epidural hematoma and a subdural hematoma may be difficult and sometimes impossible. The purpose of this paper is to review and analize the radiographic findings of 23 epidural and 45 subdural hematomas, which were surgically proven at S.N.U. Hospital during the period from July 1972 through July 1975, with emphasis on differential diagonstic aspects. Roentgen analysis is based on incidence of skull farcture, shape of avasular zone and various characteristic angiograhic signs. The results are as follows: 1. Simple skull roentgenograms reveal fractures in 19 cases out of 23 epidural hematomas and in 18 cases out or 45 subdural hematomas. None of 8 chronic subdural hematomas shows skull farcture. 2. On cerebral angiography, epidural hematomas reveal typical lentiform avascular zone in 10 cases, semilunar shape in 2 cases and crescent shape in 3 cases, while subdural hematomas reveal crescent avascular zone in 18 cases, emilunar avascular zone in 4 cases and lentiform in 3 cases. 3 lentiform avascular zones of subdural hematoma are all found in cases of chronic stage and over 40 years of age. 3. In epidural hematomas, extravasation of contrast media (7 cases), displacement of dural sinus from inner tables(5 cases), medial displacement of middle meningeal artery (3 cases), amputation of middle meningeal artery (1 case) and pseudoaneurysm of middle meningeal artery (1 case) were observed, while only one case of extravasation of contrast media was observed in subdural hematomas.

폐기형종 일례보고

장기현 대한영상의학회 1974 대한영상의학회지 Vol.10 No.2

The majority of intrathoracic teratoma are found in the mediastinum and those which occur in the lung are among the rarest of tumors. A case of intrapulmonary teratoma in a young Korean woman is reported, with brief review of the literatures. the teratoma presented radiologically in the right middle lobe as a well defined mass shadow which contained crescent shaped air and multiple nodularities with calcification.

뇌질환의 자기공명영상

장기현 대한의학협회 1990 대한의학협회지 Vol.33 No.7

Effect of Stimulus Rate and Gender on Auditory Middle Latency Response in Young Adults

장기현,최성희,최철희 한국청각언어재활학회 2017 Audiology and Speech Research Vol.13 No.2

Purpose: The main objective of this study was to investigate the effect of stimulus rate and gender on the latency and amplitude of the auditory middle latency response (AMLR) in Korean young females and males. Methods: A total of thirty young subjects consisting of fifteen males and fifteen females participated in the study. The stimulus repetition rate was changed in five steps: 0.5, 1, 2, 4, and 8/s. Results: The results showed significant differences of the stimulus rates on the Na latency, Pa amplitude, and Nb amplitude. With faster stimulus rates, the Na latency and the Nb amplitude slightly increased while the Pa amplitude decreased. The Na, Pa, and Nb latencies were longest with the stimulus rate of 2/s. The Na and Nb amplitudes were largest with the stimulus rate of 4/s while the Pb amplitude was largest with the stimulus rate of 1/s. There were significant differences in the latency of Na and the amplitudes of Na, Pa, Nb, and Pb according to gender. The latencies of Na, Pa, Nb, and Pb in females were longer than in males while the amplitudes of Na, Pa, Nb, and Pb in males are larger than in females. Conclusion: The ranges of optimal stimulus rate to elicit the apparent AMLR waveform were 1-8/s. This provides clinical basic data of stimulus rate and gender-specific norms on the latency and amplitude of the AMLR waveform.

후두개와종양의 전산화단층촬영 소견에 대한 고찰 -혈관조영 및 전산화단층촬영 소견의 비교

장기현 대한영상의학회 1980 대한영상의학회지 Vol.16 No.1

Authors present 16 cases of posterior fossa tumors in which both vertebral angiography and computed tomography were performed and pathologic diagnosis verified at Seoul National University Hospital form January, 1978 through December, 1979. The radiographic finding are analyzed with emphasis on abnormal vascularity on angiography and computed tomographic findings. The purpose of this study is to understand the correlation between angiographic vascularityand contrast enhancement on post-contrast scan. The results are as follows : 1. The C.T.scan of all the cases show contrast enhancement , whereas only 6 cases show abnomal vascularity on angiogrpahy. 2. Angiographic abnormal vasculatures influence onstrong contrast enhancement on C.T. but the converse is not necessarily true. 3. The vertebral angiography appears to be of less diagnostic value for cases with slight contrast enhancement on C.T. than for cases with strong enhancement on C.T.

VLSI 기술발전과 전망

장기현 대한전자공학회 1980 電子工學會雜誌 Vol.7 No.4

Radiation 손상에 기인한 실리콘 특성변화

장기현 대한전자공학회 1978 전자공학회지 Vol.15 No.4

실리콘 태양전지의 수명을 예측하기 위하여 1 MeV electron radiation으로 인한 실리콘 손상을 조사 연구하였다. 그 결과 흑형 실리콘에 있어서는 거의 안정상태의 손상에 이르렀음을 보았다. For a long life photovoltaic cell the degradation of the device characteristics with 1 MeV electron radiation must be known so as to be able to predict the life of the cell. Hence, a study was made of radiation damage effects on the bulk properties of the silicon crystal. From the results of the data, it is concluded that there appeared to be a steads rotate damage level reached in f type material.

실험적 진주종에서 병변의 부위와 병기에 따른 세포고사 발현의 변화

장기현,김형종 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.1

Background and Objectives:Aural cholesteatoma is a destructive disease of the middle ear caused by progresive expansion of keratinizing squamous epithelium. Previous studies reported that apoptosis of keratinizing squamous epithelium was incre-of apoptosis using expresion of bcl-2, p53 and bax in various sites of experimental cholesteatomas. We also investigated the degree of apoptosis in different clinical stages of cholesteatoma. Materials and Method:Using canal ligation cholesteatoma in mongolian gerbil, we performed imunohistochemical stainings of bcl-2, p53 and bax. Labeling indices of bcl-2 and p53 expre-ssoin and subjective grading of bax expression were measured and analyzed according to the site and clinical stage of chole-steatoma. Results:1) Expression of bcl-2 and p53 were significantly increased at lateral external auditory canal compared with those at the tympanic membrane. 2) Expression of bax of cholesteatoma was significantly increased compared with that of the normal external auditory canal. 3) Expresion of bcl-2 and bax were significantly increased in the stage I and expresion of p53 was increased in the stage III of cholesteatoma. Conclusion:Changes of bcl-2, p53 and bax expresion in experimental chole-according to the diferent sites and diferent clinical stages of cholesteatoma. (Korean J Otolaryngol 2003 ;46 :8-15)