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아졸을 포함하는 신규 세파로스포린 유도체의 합성 및 항균력
임중인(Joong In Lim),신현태(Hyun Tae Shin),조종환(Chong Hwan Cho),양재성(Jae Seong Yang),윤석균(Suk Kyoon Yoon),김원배(Won Bae Kim),장민선(Min Sun Chang),최성학(Seong Hak Choi),임원빈(Weon Bin Im),이재걸(Jae Keon Rhee) 대한약학회 2000 약학회지 Vol.44 No.4
9 New cephalosporin derivatives were synthesized and screened for antibacterial activities against various bacteria. (6R,7R)-7beta-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetamido]-3-[(2-hydroxycarbamoyl)-s-triazolo[1,5-al-pyrimidin-7-yl]thiomethyl]-3-cephem-4-carboxylic acid sodium salt (compound 3) showed 2 fold enhanced in vitro activity against P. aerurginosa, compared to ceftazidime.
Sestamibi 의 신규합성과 제제화에 따른 안정성 비교
손미원(Mi Won Son),임중인(Joong In Lim),장영수(Young Soo Chang),정미영(Mi Young Jung),정낙신(Lak Shin Jeong),김순회(Soon Hoe Kim),김원배(Won Bae Kim),정재민(Jae Min Jeong) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.5
N/A Purpose: Ascorbic acid is known to act as an antioxidant. Therefore, it can be used in increasing the efficiency of radiochemical labeling of Technetium-99m setamibi by inhibition of oxidation of Sn2+ at low concentration. We intended to estimate the efficiency of radiochemical labeling and the stability of the newly formed formulation when ascorbic acid was added to a commercial kit. Materials and Methods: Synthesis of sestamibi was performed according to Dong-A`s patent procedure (No.10-2001-0012877). First, we undertook a study to evaluate the efficiency of radiochemical labeling of sestamibi containing ascorbic acid. The stability of the vials was assessed using either 7.5 ㎍ or 75 ㎍ of ascorbic acid, added to commercial vials under the accelerated condition(Temp: 40℃, +2℃, Relative humidity: 75±5%). Results: Sestamibi was synthesized in overall 35-40% yield over 5 steps from a commercially available methallyl chloride as a starting material. When ascorbic acid was added, the efficiency of radiochemical labeling was maintained compared to the vial with no ascorbic acid. The accelerated test showed that the addition of ascorbic acid inhibited the oxidation of Sn2+ ion by antioxidation mechanism. Also, the efficiency of radiochemical labeling of this vial after 9 months was nearly the same as the starting point. Therefore, the storage period of the kit is likely to be extended. Taken together, it suggests that the addition of ascorbic acid as a stabilizer is desirable. Conclusion: To increase the stability of a sestamibi cold kit, it is desirable to add ascorbic acid as a stabilizer to the commercial fomulation. (Korean J Nucl Med 2001:35:334-341)