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이홍석 연세대학교 의과대학 의사학과 의학사연구소 2011 연세의사학 Vol.14 No.2

Electromagnetic Characteristics of the Superconducting Magnets for the 28-GHz ECR Ion Source

이홍석,강종오,강형구,허정일,최석진,김용환,홍종기 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.3

Many laboratories have been involved in the development of electron cyclotron resonance (ECR)ion source for linear accelerators all over the world. The superconducting magnets for the 28-GHzECR ion source consist of a Hexapole Coil and four Solenoid Coils. The Solenoid Coils produce anaxial mirror magnetic field, and the Hexapole Coil produces a radial magnetic field. In this paper,the specifications of the superconducting magnets for the 28-GHz ECR ion source are deduced byusing the finite-element method (FEM) to perform simulations. The research presents the resultof analyses on the magnetic field and the electromagnetic force of the superconducting magnets forthe ECR ion source for different the conditions of the Inner Yokes. The design of the Inner Yokesfor a Hexapole Coil is performed to enhance the characteristics of the radial magnetic field and tolower the operating current level.

Effects of SiO₂ Encapsulation and Laser Processing on Single CdTe/ZnTe Quantum Dots Grown on Si (001) Substrates

이홍석,김태환,이인원,Armando Rastelli,Oliver G. Schmidt 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.21

Micro-photoluminescence (μ-PL) measurements are carried out to investigate the effects of SiO₂encapsulation and laser processing of single CdTe/ZnTe quantum dots (QDs) grown on Si (001)substrates by using molecular beam epitaxy and atomic layer epitaxy. After laser processing, the μ-PL peak shift for the 200-nm SiO₂capped single QD is larger than that of the as-grown sample. The large μ-PL peak shift in the 200-nm SiO₂capped sample is related to the compressive stress induced by the ZnTe cap layer during laser processing. These results indicate that SiO₂encapsulation and laser processing represent effective methods for achieving local wavelength tuning in single QDs.

한국인 정신분열증 환자의 도파민 D2 수용체 유전자의 TaqI 다형성 분포에 관한 연구

이홍석,이민수,서광윤 대한신경정신의학회 1995 신경정신의학 Vol.34 No.6

Objects : The finding of contrasting results regarding an association between schizophrenia, alcoholism and the TaqI polymorphism site in the dopamine D2 receptor gene prompted us to study the distribution of this polymorphism in a Korean schizophrenic patients and controls. Method : Schizophrenic patients(n = 72) and controls(n = 66) were examined by case-control study for distribution of the TaqI polymorphism of the dopamine D2 receptor gene in a Korean population to minimize the effect of racial differencies in gene frequencies. Results : The frequency of the A l allele in schizophrenics and controls was 0.48 and 0.29, respectively. There was a significant difference in the frequency of the A l allele between schizophrenics and controls(x2= 11.13, p < .05), but no significant difference between positive and negative schizophrenics(x2 = 0.908, p > 0.5). Conclusion : This suggests that contribution of this gene to the liability to develop schizophrenia may be possible. However, the possibility that the gene is not a genetic determinant in the etiology of schizophrenia cannot be definitely excluded because of the intrinsic limitation of the methods of analysis, the number of subjects studied, other contradictory findings by other studies and similar increase in prevalence of the Al allele in spectrum of the disorders that share common pathophysiologic genetic mechanisms. So the present results should be considered preliminary.

大豆의 密植多收型 品種選定에 關한 育種學的 硏究 : 1報. 裁植密度反應의 品種間差異

이홍석 서울대학교 1974 서울대학교 論文集 Vol.24 No.-

The seven soybean varieties which are quite different in plant type were studied for the test of adaptability to the higher planting density in connection with the combination of three levels of row space and three levels of intra-row space. The results obtained were summarized as follows; 1. The dense planting responses for grain yield among varieties were different. Grain yield was significantly increased as the planting density was increased. The decrease in intra-row space showed more contribution in increasing the grain yield than the row space. The SRF-300 and Verde showed outstanding increase in yield by decrease of the row space. The yield of these varieties was increased as the number of plants per unit area was increased, whereas Kwangkyo did not show any relationship between yield and number of plants per unit area. Other varieties showed the increase of yield by increasing the density up to 110-150 plants per 3.3㎡, but grain yield was not increased by further increase of planting density. In same density, yields were considerably effected by the different combination of hill space and row space. The SRF-300 showed the highest grain yield under the most dense population, which may suggest outstanding adaptability of this variety. In case of sparse planting, the difference among the varieties in main stem dependability for the grain yield was remarkable, showing the characteristics of different plant type. In dense planting, however, varietal difference of the main stem dependability for the grain yield became smaller. Yields were entirely depended on main stem for the higher hield varieties under dense planting condition. 2. Leaf area index(LAI) was remarkably increased in response to dense planting, mainly by the decrease of intra-row space. The increase of LAI was different among the varieties. The grain yield was generally increased when LAI was increased up to 5, while the SRF-300 which has the best adaptability to dense planting showed maximum grain yield under the condition of LAI 3.

전장(戰場)의 한 귀퉁이에서 ― 젊은 연구자들의 한국사 교과서 논쟁 뒷담화

이홍석,전영욱,정무용,최우석 역사문제연구소 2014 역사문제연구 Vol.18 No.1

식도, 위, 십이지장에 발생한 삼중암 1예

이홍석,김동춘,김성열,이영석,정강욱,장병국,정우진,박경식,조광범,황재석,안성훈 대한소화기내시경학회 2006 Clinical Endoscopy Vol.32 No.5

Multiple primary cancer is defined as the multiple occurrence of malignant neoplasm in the same individual. The incidence of multiple primary cancer is 0.26∼1.43% in Korea, but this malady is increasing due to development of diagnostic modalities, the treatment of cancer and the recording of accurate cancer statistics. The most common site of multiple primary cancer in Korea is the stomach, colon, breast, cervix, liver and lung. We report here on a case of triple cancer that was located at the middle esophagus, stomach and duodenum in 75 year-old man. (Korean J Gastrointest Endosc 2006;32:333-337) 다발성 원발성 악성종양은 Billroth가 처음 보고한 이래 국내에서도 발생빈도가 0.26~1.43%로 보고되고 있으며, 최근 의학의 발달에 의한 평균 수명의 증가와 악성 종양에 대한 진단기술과 치료방법의 발달로 다발성 원발성 악성종양을 진단하는 빈도가 증가하고 있다. 국내에서는 다발성 중복암의 호발 장기는 위장관계, 비뇨생식계, 폐, 유방, 간 등으로 알려져 있으며 식도, 위, 십이지장에 순차적으로 발생한 삼중암에 대한 보고는 아직까지 없었다. 이에 저자들은 75세 남자 환자에서 식도, 위, 십이지장에 순차적으로 발생하여 조직학적으로 삼중암으로 진단된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

근접감시용 무인항공기 시스템을 위한 영상 안정화 알고리즘

이홍석,고윤호,김병수 제어로봇시스템학회 2008 제어로봇시스템학회 국내학술대회 논문집 Vol.2008 No.10

This paper proposes an image processing algorithm to stabilize shaken scenes by estimation and compensating its motion for close watching UAV(Unmanned Aerial Vehicle). In the proposed method the global motion between two continuous image is modeled by 6 parameters warping model, and the global intensity change caused by automatic exposure and cloud is linearly modeled. All modeled parameters are estimated by non-linear least square method based on Gauss-Newton algorithm considering only no outlier region. In order to improve the convergence speed of the parameter estimation the proposed method uses a hierarchical searching scheme based on sub-sampling and different estimation precision criterions in each hierarchy. Experimental results show that the proposed algorithm effectively stabilize shaken scenes and requires 110ms for processing each frame.

정신분열병 환자의 흡연에 대한 도파민 D2 수용체 유전자의 영향

이홍석,김승현,이헌정,김태우,한덕정,김용구,김린,이민수,손봉기 대한신경정신의학회 2001 신경정신의학 Vol.40 No.6

연구목적: 저자들은 정신분열병 환자들의 흡연에 미치는 DRD2 TaqⅠ다형성의 영향을 조사하고자 하였다. 또한 본 연 구는 정신분열병 환자의 흡연에 대한 유전학적 영향에 있어 분자잡종강세와 성별 차이의 영향을 조사하고자 하였다. 방 법: 연구대상은 167명의 정신분열병 환자들이었으며, 이들 중 96명의 환자가 흡연군, 71명이 비흡연군에 포함되 었다. DRD2 TaqⅠRFLP 유전자형 분석이 피험자로부터 추출된 DNA를 대상으로 시행되었다. 결 과: 전체 정신분열병 환자에서, Al 대립유전자의 빈도와 prevalence, 유전자형 분포, 이형접합제의 빈도에 있 어 흡연군과 비흡연군간에 유의한 차이가 없었다. 그러나 남성 정신분열병 환자군(N=101)에서는 흡연군의 유전자형 분포(p=0.010), A1 대립유전자 prevalence(p=0.020), 이형접합체 빈도가 비흡연군과 유의한 차이를 보였다(p=0.005). 남성 정신분열병군에서 이형접합체군이 동형접합체군보다 유의하게 높은 흡연율 을 보였으며, 비흡연군에서 이형접합체가 적게 나타났다. 비흡연 군에서 유전자형 분포가 Hardy-Weinberg equilibrium의 예측치를 벗어나는 양상이 나타났으나, 남녀가 서로 반대의 방향으로 나타났다. 또한 남, 여 비흡 연 환자군 간에서 A1 prevalence(p=0.001), 유전자형 분포(p=0.00011), 이형접합체 빈도(p=0.00003) 에서 있어 매우 유의한 차이를 보였다. 결 론: 본 연구에서 DRD2 유전자형은 흡연군과 비흡연군간에 유의한 차이가 없었다. 이것은 성별에 따라 DRD2 A1 대립유전자의 유전적 영향이 반대로 미치는 성별 차이에 기인한 것으로 설명될 수 있겠다. 본 연구의 결과는 DRD2 유전자에서의 분자 잡종강세 현상이 있을 수 있음을 제안하는 것이다. Objective:The authors examined the genetic effect of DRD2 Taq I polymorphism to the smoking in the Korean schizophrenics. Also this study examined molecular heterosis and gender difference in the genetic effect to smoking in schizophrenics. Methods:The study subjects were composed of 167 schizophrenic patients, 96 smokers and 71 non-smokers. DRD2 TaqⅠRFLP genotyping was carried out with DNA extracted from subjects blood samples. Results:Among the total schizophrenics, the smokers were not significantly different from the non-smokers in respect to the frequency and prevalence of A1 allele, the genotype distribution, or frequency of heterozygotes. In male schizophrenics, genotype distribution of smoking patients differed significantly from non-smoking patients(p=0.010), with a higher prevalence of A1 allele (p=0.020) and frequency of heterozygotes(p=0.005). In male schizophrenics, A1A2 heterozygotes showed significantly higher smoking rate than A1A1 or A2A2 homozygotes and non-smokers were deficient in heterozygotes. The deviation from Hardy-Weinberg expectations was observed in male and female non-smokers with opposite directions. Moreover, highly significant differences were seen between male and female non-smokers in A1 prevalence(p=0.001), genotype distribution(p< 0.00011), and frequency of heterozygotes(p<0.00003). Conclusion:No significant difference between smokers and non-smokers in the genotype distributions of the total sample could be explained by the gender difference in the genetic effect of DRD2 A1 allele to the smoking with opposite directions. Our findings support molecular heterosis at the DRD2 gene.

제1발표장 : 농산물,식품가공공학 분야 ; Vis/NIR 반투과 분광측정법을 이용한 방울토마토 내부품질 측정기술 개발

이홍석,송재빈,라리트,칸트발,김영식,조병관 한국농업기계학회 2013 한국농업기계학회 학술발표논문집 Vol.18 No.2