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Behcet 병 환자의 Natural Killer Cell 활성치에 관한 연구
이춘봉(Chun Bong Lee),김낙인(Nack In Kim),이무형(Moo Hyung Lee),허충림(Choong Rim Haw) 대한피부과학회 1987 大韓皮膚科學會誌 Vol.25 No.6
Recently, many investigators demonstrate that immunologic mechanisms seem to play an important role in the pathogenesis of Behcet's disease. The present study was undertaken to see the possible roles of NK cell activity in the pathogenesis of Behcet's disease and relationship among NK cell and T-cell and T-subsets. Authors evaluated NK cell activities in 14 patients and T cell, t-subsets in 7 patients. The results were as follows ; 1. The mean value of NK cell activities showed no statistically significant difference between patients group(57.1+15.8) and normal healthy control group(56.1+16.2). 2. The mean value of T cell(T), T-subsets(T,T)in 7 patients group 74.4+9.8, 41. 6+8.0, 24.4+10.1 showed no statistically significance compared with the mean value of normal healthy control group 67.5+4.3, 39.7+5.6,26.3+6.0 respectively. 3. The mean value of NK cell activities showed no statistically significant difference between 7 complete type patients' group(49.6+13.1) and 7 incomplete type patients' group(64.4+15.6)
이춘봉(Chun Bong Lee),이무형(Moo Hyung Lee),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.6
We presents a case of metastatic squarnous cell carcinoma(SCC) with multiple Bowen's disease. A 34--year-old rnale patient visited our OPD due to a bady-fist sized hard palpable mass on the left inguinal area and multiple, scattered, brownish, variable sized, verrucous papules on the whole body. About 6 months later, he cornplained dyspnea and collapsed left lower lobe was seen in the chest PA. Histopathologically, metastatic SCC and Bowen's disease were seen in the sections frorn left inguinal mass, lung lesion and verruous papule respectively. We suspected that left inguinal mass and lung lesion is metastasized from right palm lesion.
Retinoids가각질형성세포에서 감마인터페론에 의한 HLA - DR , ICAM - 1 발현에 미치는 영향
이춘봉(Choong Bong Lee),심우영(Woo Young Sim),박재경(Jai Kyung Park),허충림(Choong Rim Haw) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.1
Background : Retinoids exert a wide range of effects on cell growth and development and have important effects on keratinocytes differentiation in vvc and in vitro. Besides the effects on epithelial differeotiation, modulation of cellular and amoral responses of lymphocytes, changes in natural killer and T-killer cell activities and riodulation of antigen presenting properties were shown by retionds. Objective : We studied to investigate the immunologic role of etinoids. Methods : With foreskin. the effects of 13-cis retinoic acid and etretinate on interferony induced HLA-DR and ICAM-1 expression of kratinocytes were!ev luated. Results : 1. When keratinocytes were grown in low calcium media, priliferation was inhibited only with 8 x 10 M of 13-cis retinoic acid. 8 x 10 , 8 x 10 M of 13-cis retinoic acid and 8 x 10 , 8 x 10, 8 x 10 M of etretinate had no effect on keratinocytes roiferation. When cultured in 0.15 mM calcium media or 1.0 mM calcium media, 13-cis retino acid and etretinate had no effection keratinocytes proliferation. 2. Keratinocytes HLA-DR expression was decreased with 8 x 10 , 8 x 10 M of 13-cis retinoic acid in 0.15 mM carcium media and 8 x 10 , 8 x 10 M of 13-cis retinoic acid in 1.0 mM calcium media. Etretinate had no effect on keratinocytes HLA-DR expression. 3. Keratinocytes ICAM- 1 expression was increased with 8 x 10 M of 13-cis retinoic acid in low calcium. media. When cultured on 0.15 mM carcium media, ICAM-1 expression was increased with 8 x 10 M of 13-cis retinoic acid and tetinate. When cultured in 1.0 mM calcium media, ICAM-1 expression was increased with 8 x 10, 8 x 10 , 8 x 10 M of 13-cis retinoic acid and 8 x 10, 8 x 10 , 8 x 10 M of etretinate. Conclusion : These results suggest that retiniods have an immunomodulating effect as well as effects on epithelial differentiation. Clarification of the mechanism of increased expression of ICAM-1 and decreased expression of HLA-DR remains to the proved. (Kor J Dermatol 1995; 33(1): 33-43)
이춘봉(Chun Bong Lee),한을남(Eul Nam Han),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.2
We describe herein a 3 family members with phytophotodermatitis. After fig (juice) was applied to skin for the purpose of treating psoriasis in a 30 year-old woman and applied incidentally in her mother and 3 year-old daughter, vesicobullous eruptions developed immediately after sun-exposure, predominantly in the sun-exposed area. ln histopathology, the epidermis shows intraepidermal separation with necrosis and reepithelization on basal layer and marked spongiosis. We treated with systemic steroid, wet dressing with burow solution etc, so she healed without sequela after 2 weeks.
가족성 양성 만성천포창의 - 전자현미경적 소견의 관찰 -
김낙인(Nack In Kim),이춘봉(Choon Bong Lee),이무형(Moo Hyung),허충림(Choong Rim Haw) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5
A 25-year-old man with familial benign chronic pemphigus presented with a one-year history of a localized pruritic recurrent eruption on his perianal area, Physical examination showed moist, macerated, fissured and scaly patches on erythematous base, A biopsy specimen showed extensive intraepidermal separation containing acantholytic cells. Electron microscopic observation showed widened intercellular space, detachment of the tonofilaments from the desmosomes, and subsequent concentration of the tono filaments around the nucleus. Microvilli were elorigated, thinned and branehed. 1)esmosomes were reduced in number. This case is unique in its clinical location, showing no family tendency.
홍대광(Dae Kwang Hong),이춘봉(Choon Bong Lee),한을남(Eul Nam Han),허충림(Choong Rim Haw) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.2
We present a case of epidermodysplasia verruciformis a.ssociated with Bowen's disease. Patient was 33 year-old male and his skin lesions showed diffuse flat papules on face and neck, many brownish papules on trunk and papillomatous tumors also appeared un scalp and post auricular area, Skin biopsy findings from the flat papular lesion showed histopathologic features of verruca plana and from the papillomatous lesion showed the feature of Bowen's disease. Electron microscopic finding from the flat papular lesion showed marked aggregates of viral particles around the nuclei of epidermal keratinocytes.