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자연폐경여성에서 interleukin(IL)-6 유전자내 (CA) 반복다형성, 혈청 IL-6농도 및 골밀도와의 연관성
김정구(Jung Gu Kim),김석현(Seok Hyun Kim),최영민(Young Min Choi),문신용(Shin Yong Moon),이진용(Jing Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective: To investigate the relationship between cytosine-adenosine(CA) polymorphism in interleukin-6 (IL-6) gene, serum IL-6 levels and bone mineral density (BMD). Methods : IL-6 CA polymorphism was analyzed by polyacrylamide-urea gel electrophoretic patterns in 300 postmenopausal Korean women. and direct DNA sequencing. Serum IL-6 was measured by enzyme linked immunosorbent assay, and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. Results: Nine alleles were observed with product sizes ranging between 120-136 bp and 125 allele was the most common. There were no significant differences in serum IL-6 levels and BMD at the lumbar spine and proximal femur between the women who possessed at least one allele of each genotype and those who did not posses that allele. Serum IL-6 levels did not correlated with age, menopause duration, body mass index and BMD at the lumbar spine and proximal femur. IL-6 CA polymorphic pattern and serum IL-6 levels in osteoporotic women were not different from those in normal BMD or osteopenic women. Conclusions: IL-6 CA polymorphism has no relationship with serum IL-6 levels and BMD in postmenopausal Korean women.
구승엽(Seung Yup Ku),최영민(Young Min Choi),정병준(Byeong Jun Jung),서창석(Chang Suk Suh),김석현(Seok Hyun Kim),김정구(Jung Gu Kim),문신용(Shin Yong Moon),이진용(Jing Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objectives : To assess the prevalence of autoantibodies in patients with endometriosis. Materials and Methods : The prevalence of autoantibodies were investigated in 93 patients with endometriosis diagnosed by laparoscopy or laparotomy. Autoantibodies, such as antithyroglobulin antibody, antimicrosomal antibody, antinuclear antibody (ANA), antiphospho -lipid antibody (APA), lupus anticoagulant (LAC), anti-dsDNA, and rheumatoid factor, were measured in sera of the subjects. The prevalence and distribution of autoantibodies were analyzed according to the stage of endometriosis. Results : All seven autoantibodies were checked in 73 patients out of 93 patients. Autoantibodies were identified in 23 of 73 patients with endometriosis (31.5%). Antibodies detected were antithyroglobulin antibody (15.2%), ANA (12.0%), antimicrosomal antibody (8.7%), anti-dsDNA (5.4%), and rheumatoid factor (4.4%), APA (2.2%) and LAC (1.3%). The prevalence of autoantibodies did not differ by the AFS stage. Conclusion : Autoantibodies were detected in about one-third of patients with endometriosis. The prevalence of autoantibodies did not differ by the stage.
종양괴사인자-α가 배양된 인간 황체화과립막세포의 에스트라디올, 프로게스테론, 인슐린유사성장인자-II, 인슐린유사성장인자 결합단백질-1, 2, 3의 분비에 미치는 영향
채희동(Hee Dong Chae),강은희(Eun Hee Kang),박은주(Eun Ju Park),김성훈(Sung Hoon Kim),홍석호(Seok Ho Hong),김정훈(Chung Hoon Kim),강병문(Byung Moon Kang),장윤석(Yoon Seok Chang),김정구(Jung Gu Kim),이진용(Jing Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
N/A Objectives : To investigate the influence of TNF-α on the secretion of estradiol (E2), progesterone (P4), insulin-like growth factor (IGF)-II, insulin-like growth factor binding protein (IGFBP)-1, 2, and 3 in cultured human luteinized granulosa cells. Materials and Methods : Human luteinized granulosa cells were obtained from the follicular fluid by transvaginal oocyte aspiration from infertile patients undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). The cells were grouped into the control, 1.0, 10.0, and 100.0 ng/ml of TNF-α group according to the concentrations of TNF-α. The cells were cultured for 72 hours with the different concentrations of TNF-α as descibed above. The cells not treated with TNF-α served as control. The concentrations of E2, P4, IGF-I, IGFBP-1, 2, and 3 were determined in conditioned culture media by immunoradiometric assay (IRMA) or radioimmunoassay (RIA). Results : The cell number in 100.0 ng/ml of TNF-α group was significantly higher than those in other groups, although the cell viabilities were similar in all groups. There were no statistically significant differences in the concentrations of E2 in all groups. However, the concentrations of P4 were seemed to be decreased as the concentrations of TNF-α were increased and the concentration of P4 in 100.0 ng/ml of TNF-α group was significantly lower than those in the control and other TNF-α groups. The concentrations of IGF-II, IGFBP-1, 2, and 3 were not different among the control and each TNF-α group. The secretion of E2 and P4 was not affected by IGF type I receptor antibody pretreatment. Conclusion : TNF-α might play a role as a regulator of ovarian physiology by modulating luteinized granulosa cellular proliferation and P4 secretion, and this mechanism might not be related to IGF system.