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이윤이 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2
This study was undertaken for the clinical analysis and evaluation on 48 patients with incompetent internal os of the cervix. who were admitted and treated at the CNUH from August, 1991 to August, 1994 1. The incidence of incompetent internal os of the cervix is approximately once in every 67 deliveries and the most frequent age incidence was 30 to 34 age group 2. The most significant contributory factor in 21 of 48 cases was considered to be the previous history of the traumatic induced abortion 3. McDonald operation was performed in 48 cases and resulted in success rate of 70.8% 4. The mayor causes of perinatal loss were SPROM (64.3%) and preterm labor(28.6%) 5. The fetal salvage rate by suture material is 72.7% (mersilene tape) and 66.7% (silk). 6. The delivery methods after operation were via vaginal route in 35 cases (72.9%) and abdominal route in 13 cases.(27.1%)
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Platelet-Activating Factor(PAF)가 과립막세포의 Progesterone생성에 미치는 영향
이윤이,강길전 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
In spite of a great deal of iteratures concerning PAF, there is no informatin on its rols on the granulosa cell. Consequently, this study was designed to explore the possible role of PAF on progesterone(P_4) secretion of the granulosa cell using the porcine granulosa cell culture. PAF enhanced P_4 secretion in dose-dependent way in medium supplemented with fetal calf serum. However, its role was not effective in culture system supplemented with bovine serum albumin. In another experiments, a great difference appears between P_4 secretion by granulosa cells from large follicles and from small of medium follicles, suggesting an influence of the stage of granulosa cell differentiation. In conclusion, the present study suggests that P_4 secretion from the cultured porcine granulosa cells is dependent upon PAF. Thus it appears likely that PAF as well as other auto-and paracrine factors modulates the P_4 secretion.
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이윤이 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
We studied 123 women with uncomplicated pregnancies of 41 or more weeks' gestation. The pregnant women with a ripe cervix over Bisphop score 7 (Induction group I, 20 cases) was done with oxytocin induction. The pregnant women with an unripe cervix Bisphop score <7, there were two alternatives in management. The one group (Induction group II, 24 cases) was administer prostaglandin vaginal tablet for cervical ripening and proceeded with oxytoion induction. The other group (Monitoring group, 69 cases) was to initiate serial antepartam surveillance white waiting spontaneous labor and/or spontaneous cervical ripening. Serial antepartum surveillance consisted of nonstress test, biophysical profile (BBP) anti assessments of amnionic fluid index by twice weekly. Among 54 women in the induction group I and II, 16 (29.6%) resulted in a higher rate of cesarean section, as compared with 15 (21.7%) of 69 women in the monitoring group. But the rate of cesarean section because of fetal distress in the monitoring group was higher than the induction group I and II (8.6% versus 5.6%) This difference was not satistically significant. Thick meconiam in amnianic fluil and meconiam aspiration syndrome in the monitoring group was significantly higher than the induction group I and II (p <0.05). They occured after 43 weeks' gestation. Therefore, in postterm pregnancy, when the cervix was ripe, induction of labor at 41 weeks' gestation was appropriate. when the cervix was unripe, serial antepartum surveillance should be initiated soon after 41 weeks' gestation and prompt intervention should occur if antepartum surveiuance was abnormal. This group must be delivered until 43 weeks' gestation.
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