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이유란,임재성,신주현,최성아,주희경,전병화 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.S1
Purpose: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in DNA repair and redox modulation. Recently, serum and urinary APE1/Ref-1 levels were reported to be increased in patients with bladder cancer. Genetic variations of APE/Ref-1 are associated with the risk of cancer. However, the effect of APE1/Ref-1 variants on its secretory activity is yet unknown. Methods: APE1/Ref-1 variants were evaluated by DNA sequencing analysis of reverse transcription polymerase chain reaction products in coding DNA sequences (CDS) of APE1/Ref-1 in bladder tissue samples from patients with bladder cancer (n=10). Secretory activity of APE1/Ref-1 variants was evaluated with immunoblot and enzyme-linked immunosorbent assay of the culture medium supernatants. Results: Four different substitution mutants (D148E, I64V/D148E, W67R/D148E, and E86G/D148E) of APE1/Ref-1 were identified in bladder cancer specimens. However, deletion mutants of APE1/Ref-1 CDS were not found. The secretory activity of the APE1/Ref-1 variants (D148E, I64V/D148E, and E86G/D148E) was increased compared to that of wild type APE1/Ref- 1. Furthermore, the secretory activity in basal or hyperacetylated conditions was much higher than that in APE1/Ref-1 D148Etransfected HEK293 cells. Conclusions: Taken together, our data suggest that the increased secretory activity of D148E might contribute to increased serum levels of APE1/Ref-1 in patients with bladder cancer.
이유란,박정아 한국미용학회 2023 한국미용학회지 Vol.29 No.5
Korea male think that good looks help interpersonal relationships and have a lot of influence on their external youth and image. In addition, men with hair loss or inappropriate hair lines seek various ways to solve it for the image they pursue. The purpose of this study is to investigate, analyze, and systematize hairline designs based on the image of Korean males and to provide basic data for effective design selection for customers and workers. According to this study, it was confirmed that there is a difference in the male hairline design according to the image, and the difference also exists in the male image and hairline type according to gender, age, and occupation. This research is expected to contribute to the growth of the beauty market industry at a time when the physical hair loss cover market is developing and the importance of hairline design is steadily increasing. In follow-up studies, it is expected that there will be in-depth research on image changes and subsequent factual studies resulting from hairline correction.