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絞扼性 腸閉鎖時의 代謝 및 組織學的 變化에 關한 實驗的 硏究
李舜濟,金相孝,白樂晥 인제대학교 1983 仁濟醫學 Vol.4 No.4
실험적인 교액성 장폐쇄에서의 혈청단백, 콜레스테를, 전해질 및 병변 장의 조직학적 변화를 시간별로 관찰함. Acute obstruction of small bowel is caused by hernia, adhesions and bands within peritoneal cavity, and that results in accumulation of fluid and gas proximal to the obstruction producing distention of the intestine. Strangulation develops when the circulation to obstructed intestine is impaired by longstanding or "closed loop" obstruction. Strangulation causes loss of blood and plasma from the strangulated segment, which may be particularly severe if the vascular obstruction is predominantly venous. Author investigated the changes of serum protein, cholesterol, electrolytes, and histological findings of strangulated intestine experimentally in the rats. The following results were obtained. 1.Serum protein was slightly decreased after 30 minutes of obstruction, but the sequential changes of serum protein levels showed no significant differences statistically throughout the experimental periods. 2.Serum cholesterol levels were gradually decreased reaching to 97.4mg/dl within three hours of obstruction in conrast with 116.8mg/dl in control group. 3.Serum calcium levels were slightly decreased after obstruction, but there were no significant differences in serum sodium and potassium levels. 4.In the histological investigation, degeneration of mucosal epithelium, submucosal congestion and edema appeared in 30 minutes of intestinal obstruction. Necrosis of mucosal epithelium, degenerative chance of muscle fiber and thrombus formation in the vessels appeared in one hour of obstruction. In the groups of two to three hours after strangulation obstruction, marked thrombus formation and necrotic changes of all intestinal wall were noticed.