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상복부 수술후 진통을 위한 경막외 약물 주입에 있어서 Clonidine 첨가 효과에 관한 연구
이선숙,최훈,한영진,이준례,백해정 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.3
Epidural narcotics has been most widely used for the control of postoperative pain. However, patients have been treated insufficiently because of the fear of respiratory depression. Urinary retension, nausea and vomiting, pruritus are other complications of epidural narcotics. Epidural local anesthetics may be an alternative to epidural narcotics. But the duration of action is usually too short, although epinephrine can prolong the analgesic effect. Clonidine, an a2-adrenergic agonist has its own analgesic effect and can prolong the effects of epidurally administered drugs. Therefore epidural clonidine may be expected to lessen the requirement of epidural narcotics and hence reduce the complications of narcotics. 75 ug or 150ug of clonidine was added to 0.125% bupivacaine or 2 mg of morphine. 6ml of mixed solution was administered epidurally during and after operation for the control of pain following upper abdominal surgery. Clonidine caused increase in the analgesic duration of epidural bupivacaine and morphine. Clonidine also cause decrease in systolic pressure in dose-dependent manner, especially during anesthesia without significant alterations in heart rate. Clonidine may be an useful adjunct to epidural narcotics, provided the dosage is carefully titrated in the range of modest hemodynamic change.
Hyers-Ulam-Rassias Stability of a Functional Equation Related to General Quadratic Mappings
이선숙,이양희 호남수학회 2017 호남수학학술지 Vol.39 No.3
In this paper, we investigate the stability of a functional equation \begin{align*} 2f(ax+by) + ab f(x-y) &+ ab f(y-x) - \frac{2af((a+b)x )}{a+b}\nonumber \\ &- \frac{bf((a+b)y )}{a+b} - \frac{bf(-(a+b)y )}{a+b}=0 \end{align*} by applying the direct method in the sense of Hyers and Ulam.
마인드맵을 활용한 집단미술치료가 읽기동기향상에 미치는 효과성연구 - 청소년수련관 초기청소년을 대상으로 -
이선숙,김혜경 한국예술치료학회 2015 한국예술치료학회지 Vol.15 No.1
본 연구의 목적은 초기청소년들을 대상으로 마인드맵을 활용한 집단미술치료가 읽기동기 향상에 미치는 효과성을 알아보 는 것이다. 본 연구의 대상은 I시의 K구 청소년 수련관 초등학생 5, 6학년 남녀학생 17인으로 집단미술치료를 실시하였다. 본 연구에서는 마인드맵의 다양한 기법을 미술치료 프로그램에서 활용하여 2014년 6월에서 12월까지 K구 청소년 수련관에 서 총 14회에 걸쳐 진행하였다. 연구의 결과는 마인드맵을 활용한 미술치료 프로그램이 초기 청소년의 읽기동기 향상에 긍정적인 영향을 준 것으로 드러났 다. 이것은 시각적인 집단상담의 미술치료가 사고 구조화의 도구인 마인드맵을 활용한 효과라고 보여 진다. 따라서 본 연구는 마인드맵을 활용한 미술치료가 다양한 청소년 집단의 읽기동기를 향상시켜 줄 것이라고 본다. This study amis is to examine effects of group art therapy using mind map program for improving of reading motive to which makes early youth improve their reading motive. Subjects of this study are 17 students of fifth and sixth grade elementary school in youth in youth Training Center of K District in the I City. It was art group therapy programmed using mind map to 14 times for the early youth in youth Training Center of K District in the I city between June and December in 2014. The summary of this study shows that art therapy program using mind map has had a positive effect to early youth on improving of reading motive. This was a effects from art therapy which visual sympathy and mind map which cognitive extension. Therefore, the study suggests that group art therapy program using mind map can be applied to improve of reading motive in youth of diverse group.
이선숙,김재완 德成女子大學校 藥學硏究所 1991 藥學論文誌 Vol.2 No.1
The fructus of Lycium chinense has been widely used for it's hypoglycemic activity, liver protective activity and antipyretic activity. This study was intended to ellucidate it's pharmacologically active principles, since there were no mentinos about these active compounds in the areas of natural product science. Before performig these analyses, water extracts were futher fractionated with ether, ethyl acetate and b-buthanol. To find out the effective fraction, each fraction of 500 ㎎/㎏ was administered into all experimintal animal models. Each fraction was administered into streptozotocin induced diabetic rats(45 ㎎/㎏, i.v, tail) for 10 days. Serum glucose levels were checked on 3, 5, 7 and 10 day and body weights were checked everyday. n-Buthanol fraction showde significant hypoglycemic effect from 5th day and maintained to 10th day. Also n-buthanol fraction gained highest body weights compared with other fractions. Each fraction was administered into CCl_4-intoxicated miuse (0.13 ㎖/㎏ P.O.) for 6 days. Measurement of sleeping time induced by hexobarbital sod. (75 ㎎/㎏, i.p.) indicated that ether fraction showed the most significant liver protective effect. Serum transaminase activity (s-GPT, s-GOT) supported this result. To find out the fraction which can be shown antipyretic effect, each fraction was given into typhoid vaccine induced febrile mouse(0.2㎖/20g, i.p.) and measured the rectal temperature intermittently. Ether fraction decreased the rectal temperature significantly.