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Licochalcone A가 대식세포주의 사이토카인 생성에 미치는 영향
이기세(Gi-Sae Lee),천승훈(Seung Hoon Cheon),이성호(Sung Ho Lee),강복윤(Bok Yun Kang),조영창(Young-Chang Cho),윤구(Goo Yoon) 대한약학회 2009 약학회지 Vol.53 No.6
Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion of proinflammatory cytokines such as IL-1β IL-6, and TNF-? The reduced secretion of proinflammatory cytokines is related to the differences in the mRNA expression of IL-1β IL-6, and TNF-α Moreover, licochalcone A inhibited the mRNA expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A reduced nuclear NF-kB binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation of binding to the kB site.