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이규섭,하명완,나상 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.6
저자는 최근 본 병원 산부인과에서 태아경부 수활액낭종 1례를 경험하였기에 이에 대한 간단한 문헌적 고찰과 함께 보고하는 바이다. It had been thought that cystic hygroma colli was diagnostic of Turners syndrome in utero and that it was the precursor of the neck webbing or redundant skin in the nuchal region found after birth. In later studies, however, cystic hygroma was found in fetuses with other chromosome abnormalities and with normal karyotypes. The term hygroma means moist tumor. Cystic hygromas are anomalies of the lymphatic system characterized by single or multiple cysts within the soft tissues, usually involving the neck. Recently, we have experienced a case of fetal cystic hygroma colli at 22 weeks of gestation observed in 25-year-old nulliparous woman, and report that with a brief review of related literatures.
자궁내막증 환자의 복강액으로 처리한 단핵구가 T-세포 반응에 미치는 영향에 관한 연구
이규섭 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20
Purpose: This study examined whether or not the PF from endometriosis patients (EPF)-treated monocytes affect the T cell response. Subject and Methods: Peritoneal fluid was obtained from endometriosis patient(n=20) and healthy control group(n=10) respectively. Peripheral blood monocytes were obtained from healthy donors by density-gradient centrifgation and THP-l cells derived from a monocyte/macrophage cell line. We examined the effects of heat-treatment and IL-10 neutralizing antibody on the down-regulation of MHC class IT expression level by EPF. The monocytes pre-treated with 10% of EPF mixture were mixed with T-cells, cultured with or without Staphylococcus enterotoxin B(SEB), and then pulsed with 1μCi of [^(5)H] thymidine. The radioactivity incorporated was determined. EPF-treated or CPF-treated monocytes were mixed with T-cells and cultured. The expression of MHC class Ⅱ was evaluated by confocal microscopic analysis, and the levels of IL-10, TGF-β and VEGF were measured by standard enzyme-linked immunosorbent assay kits(R and D system). Results: Heat-pretreatment of EPF and neutralizing IL-10 antibody abrogated MHC class Ⅱ down-regulation on monocytes, which had been induced by EPF. However, in a functional assay, monocytes treated with EPF failed to stimulate T cell in mixed leucocyte reaction, although T cell proliferation was increased with EPF-treated monocytes and SEB. Conclusion: These results suggest that the cell stimulatory ability of monocytes dose not coincide with MHC class Ⅱ expression level.
여성의 연령이 체외수정시술 결과 및 난소혈류에 미치는 영향
이규섭 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24
Objective: The purpose of this study was to assess the influence of women's age on the outcome of in vitro fertilization (IVF) and ovarian blood flow. Subject and Methods: To investigate the influence of women's age on the outcome of IVF, 266 IVF cycles were analyzed according to their age. Number of oocytes retrieved, fertilization rate, clinical pregnancy rate, and implantation rate were analyzed. Pulsatility index (PI) of the intraovarian artery was measured by transvaginal color and pulsed Doppler on the day of hCG administration in 15 women of each age group in order to find the relationship between women's age and ovarian blood flow. Results: There was no significant difference in fertilization rate but clinical pregnancy rate and PI were different significantly according to the women's aging. In particular, the pregnancy outcome and ovarian blood flow of women older 38 years were significantly decreased compared. to those of women younger than 38 years. Conclusion: As women's age increase, clinical pregnancy rate and ovarian blood flow were gradually decreased.