局所麻醉劑가 心臟機能에 미치는 影響

尹炳萊,崔世鎭,金光鎭,朴海根 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.1

Local anesthetics are drugs that block the impulse conducion in nerves. Thus, they have been used clinically for the treatment of cardiac arrythmias, but exact mechanism of their action on nerves and organs remains unknown. The object of this study is to investigate the actions or mechanisms of local anesthetics ; procaine, lidocaine, bupivacaine, and tetracaine, on the cardiovascular system and the cardiac contractility. For this study, eighty rabbits(average weight 2.0㎏) were anesthetized with subcutanous urethane(1g/㎏ wt.) for in vivo study and thirty six isolated turtle hearts for perfusion study were used. The results are summarized as follows: 1. Local anesthetics, given intravenously, were increased the respiratory rate, and decreased the blood pressure and heart rate of rabbits. And the changes were proportional to the injected drug concentrations. 2. Seven arrythmias were observed at high dosages in vivo and in vitro study 3. Local anesthetics perfused were decreased the cardiac contractility, the condition time, and dC/dT in the isolated hearts, and their changes were proportional to the drug concentrations. 4. The correlation between the changes of the cardiac contractility and the conduction time in the isolated heart was expressed as following equation : Contractility(%)=17.1-0.3conduction time(%). And the correlation coefficient(r=0.771) was statistically significant. 5. The correlation coefficient(r) between dC/dT and the conduction time or the cardiac contractility were 0.793 and 0.773 or 0.922 and 0.933, respectively. The values were statistically significant. From the above results, it was suggested that the mechanism of action of local anesthetics is caused primarily by the reversible blockade of the impulse conduction resulted from the changes of the membrane permeability of ions in the cardiac muscle.

人體氣管에서 分離한 Aspergillus의 Mouse臟器에 對한 病原性에 관한 硏究

윤병래,김익수,최세진,이태숙,장명웅 대한마취과학회 1977 Korean Journal of Anesthesiology Vol.10 No.3

Attempts were made to investigate the pathogenicity of the aspergillus species by innoculating normal mice intravenously with aspergillus suspension, 10^(5) spores/ml and 5×10^(4) spore/ml concentration and as a comparison group, concentration of hormodendrum suspension 5×10^(4) spore/ml. The following results were obained. 1) High peak mortality (51.5%) was seen at the 5th and 6th day after innoculation. 2) Cause of death was suspected as infection of the kidney. 3) Aspergillus species(mortality, 94.2%) has shown more pathogenicity than hormodendrum group (mortality 25%). 4) The main pathological changes were: in lung, 63% congestion, 37% inflammation, in liver, 63% congestion, 19% inflammation, in heart, 60% congestion, 26% inflammation, and in kidney, 81% inflammation, 52% congestion. 5) On identification of fungus with PAS stain, there were 9 cases in kidney (25.7%) and 1 case in heart (2.85).

척추마취중 발생한 심정지 1례 보고

윤병래,김익수,최세진 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

We report one case of cardiac arrest associated with total spinal anesthesia in a 17 year old boy prepared for appendectomy. The cause of cardiac arrest was presumed hypovolemia as a result of total spinal anesthesia due to anesthetics and anesthetic technicque.

人體氣管에서 分離한 Aspergillus의 Mouse 臟器에 對한 病原性에 關한 硏究

尹炳來 충남대학교 대학원 1977 論文集 Vol.9 No.-

Attempts were made to investigate pathogenicity of the aspergillus species by innoculating normal mice intravenously with Aspergillus suspension, 10^(5)spore/ml and 5×10⁴spore/ml concentration and as a comparison group, concentration of Hormodendurm suspension was 10^(5)spore/ml, The following results were obtained. 1) High peak motality(51.5%) was seen at the 5th and 6th day after innoculation, 2) Cause of death was suspected the infection of the kidney. 3) Aspergillus species(motality, 94.2%) was seen more pathogenicity than Hormodendrum group(Motality 25%). 4) Main pathological changes were : in lung, 63% congestion, 37% inflammation, in liver, 63% congestion, 19% inflammation, in hert, 60% congestion, 26% infalammation, and in kidney, 81% inflammation, 52% congestion. 5) In identification of fungus with PAS stain, there were 9 cases in kidney(25.7%) and 1 case in heart(28.5%).

식도이물 제거중 발생한 급성 심정지 1 례 보고

최세진,윤병래,김익수 대한마취과학회 1976 Korean Journal of Anesthesiology Vol.9 No.1

We have experienced one case of acute cardiac arrest occurred during removal of a foreign body in the esophagus in a 8 month old boy. We consider the cause of acute cardiac arrest in this patient as acute hypoxia and vagal reflex, and stress the importance of prompt diagnosis, extensive knowledge and correct and skillful resuscitation.

수술후 발생한 기관지 폐쇄증 치험 1예 보고 : A Case Report

박대팔,김준호,윤병래,김익수,최세진 한국의 현대의학사 1975 한국의 현대의학 Vol.8 No.2

Flaxedil-Pentothal Sodium-Succinylcholine 주입후 혈중 K+, Na+ 및 Cl- 농도의 변화에 관한 연구

김익수,최세진,윤병래 대한마취과학회 1978 Korean Journal of Anesthesiology Vol.11 No.1

Transient hyperkalemia is well known to occur in man following intravenous administration of succinylcholine chloride. To study on change of the serum level of K+, Na+ & Cl- after injetion of succinylcholine in healthy adults, physical status 1 or 2 adopted by the American society of Anesthesiologists, we studied in two grcups: pentothal sodium-succinylcholine injetion group (group 1) as control, flaxedil-pentothal sodium-succinylcholine injetion group(group 2) as experimental. The following results were obtained: 1. Serum K+ was slightly increased in both groups, 2mEq/L at 3rd minute in control group, 2mEq/L at 1st minute in experimental group after succinylcholine injection, but no statistical significance was noticed in either group. 2. Serum Na+ was decreased 3mEq/L immediately after pentothal sodium injetion and then sliyhtly increased untill 10th minute in control group. In experimental group lower level than control was observed untill 15th minute, with the maximum decrease of 7mEq/L at 5th minute. But no statistical significance was noticed in either group. 3. Serum Cl was slightly decreased untill 10th minute with the maximum decrease of 4mEq/L at 5th minute in control group. In experimental group, it was slightly increased untill 5th minute. But no significance was noticed in either group.

측뇌실내 Atropine 이 가토 심박수에 미치는 영향

김익수,최세진,이재흔,윤병래,석정호 대한마취과학회 1978 Korean Journal of Anesthesiology Vol.11 No.3

The effects of intraventricular atropine on the heart rate was investigated in the rabbit. Intraventricular administration of atropine in a dose of 10, 30, 100, or 300 ug produced dose dependant bradycardia. Atropine (100 ug) induced bradycardia was abolished by bilateral vagotomy or intravenous atropine, and inhibited by intravenous propranolol but not by intravenous Regitine. Intraventricular Ecolid or regitine pretreatment diminished the bradycardia induced by intraventricular atropine. From the above results, it is suggested that a central adrenergic mechanism as well as vagal activity plays an important role in the intraventricular atropine-induced bradycardia.

수술후 발생한 기관지 폐쇄증 치험 1 예 보고

김익수,김준호,최세진,박대팔,윤병래 대한마취과학회 1975 Korean Journal of Anesthesiology Vol.8 No.2

After a cholecystoduodenostomy on a 3 year old poor risk girl under local anesthesia, atelectasis developed. On the 8th postoperative day, an endotracheal tube was inserted with the patient eonscious and tenacions secretions were aspirated. Again on the 10th post operative day, after intubatioa under general anesthesia, aspiration of mucus and positive pressure ventilation were applied, the child then recovered.