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RISS 인기검색어
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- 저자 : 윤기주(Key Joo Yoon) (검색결과 1 건)
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HBsAg 양성 간경화증 환자에서 Anti - HBc IgM 의 임상적 의의
김부성(Boo Sung Kim),이창돈(Chang Don Lee),안성홍(Sung Hong Ahn),박영민(Young Min Park),윤기주(Key Joo Yoon),최성호(Sung Ho choi) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3
N/A We studied the clinical significance of anti-HBc IgM tested by immunoradiometric assay kit (Sorin) in 45 patients with HBsAg positive liver cirrhosis (LC). Anti-HBc IgM positive LC were 17 and anti-HBc IgM negative LC as a control who was randomly selected were 28. LC with hepatocellularcarcinoma (LC+HCC) were 20 and the positive rate for anti-HBc IgM was 25%, while 48% in LC without hepatocellular carcinoma (LC HCC; n=25). The positive rate for anti-HBc IgM in HBeAg positive LC (n=19) was 52.6%, while 28.6% in HBeAb positive LC (n=21). The positive rate for anti-HBc IgM in HBcAg positive LC+HCC (n=6) was 33%, while 23.1% in HBeAb positive LC+ HCC (n=13). However, a significant correlation between HBeAg positivity and the younger group (group I; 40 y/o) was noted; the frequency for HBeAg and anti-HBc IgM in group I was 60% and 40 %, respectively, while 43% and 39.3% in the older group (group II: between 40 and 59 %), respectively. The ratio between LC+HCC and LC HCC in each age group was (1:3.5) in group I, (1:1.3) in group II, and (2.5:1) in group III (60%). So we could find the aging effect to HBeAg-Ab system and the frequency of HCC; higher positive rate for HBeAg and lower frequency for HCC in the younger group (40%), while higher positive rate for HBeAb and higher frequency for HCC in the older group (60 %). Similar frequencies for both parameters were observed in group II. Therefore, no correlation between anti-HBc IgM and HBeAg-Ab system or HCC were noted practically. There were no correlation between anti-HBc IgM and serum level of ALT, globulin, and AFP (alpha-fetoprotein), or the severity of hepatic failure (represented by Pughs score). In conclusion, this study indicates that anti-HBc IgM is not useful clinically in HBsAg positive liver cirrhosis because of its inability to differentiate LC+HCC from LC-HCC, to distinguish the milder hepatic failure from the severe hepatic failure, to represent the severity or activity of the ongoing inflammation and to predict the development of HCC as one of the high risk factor of HCC in LC. And the aging effect to HBeAg-Ab system and the frequency of HCC in HBsAg positive LC in Korea should be considered.
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