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유한동,심우영,허충림 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2
Terbinafine is an allylamine antifungal agent with a primarily fungicidal action in vitro. Its spectrum includes dermatophyte, filamentous, dimorphic and dermaticaceous fungi and some yeast species. Terbinafine inhibits squalene epoxidation. The treated fungi accumulate squalene while becoming deficient in ergosterol, and essential component of fungal cell membrane. The cidal activity of terbinafine is closely related with the increased intracelluar squalene concentraion. But in the case of candida albicans, growth inhibition with terbinafie apperars to result from ergosterol deficiency. We experienced a patient with onychomycosis of fingernail caused by candida albicans. He was treated with terbinafine 250㎎ daily for 8 weeks. After completion of therapy, fingernail showed complete recovery and we could not see any laboratory abnormalities or adverse reactions.