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- 저자 : 유박린 ( Bark Lin Lew ) (검색결과 4 건)
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알부틴과 베타-글루코시다제를 함유하는 미백 화장품의 항멜라닌 효과
유박린 ( Bark-lin Lew ),류지호 ( Ji-ho Ryou ),이무형 ( Mu-hyoung Lee ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.3
알부틴은 glycosylated hydroquinone으로 여러 식물들에서, 고농도로 발견되며 비교적 안정한 물질이다. 이는 멜라닌화를 억제하는 작용이 있는 것으로 보고되어 있고, 베타-글루코시다제에 의해 포도당과 hydroquinone으로 쉽게 가수분해된다. Hydroquinone 역시 우수한 항멜라닌화 작용을 가지나, 여러 가지 부작용들로 인해 그 사용이 제한적이거나 주의를 요한다. 이 연구는 알부틴과 베타-글루코시다제를 포함하는 미백 화장품이 자외선 조사로 유도된 색소 침착을 억제하는 효과를 알아보고자 하였다. 대상은 10명의 건강한 성인으로 등 부위에 자외선 B를 조사하여 색소 침착 병변을 만들었고 이 병변들은 세 그룹: 알부틴과 베타-글루코시다제를 함유하는 미백 화장품 도포군, vehicle 대조군, no-application 대조군으로 나누었다. 알부틴과 베타-글주코시다제를 함유하는 미백 화장품 도포군은 no-application 대조군에 비교하여 색소 침착을 50.17% 억제하였다(N = 10: P < 0.05). 따라서 알부틴과 베타-글루코시다제를 함유하는 미백 화장품이 기미 등 자외선 조사로 유도되거나 악화되는 과색소성 질환에 효과적으로 사용될 수 있겠다. Arbutin is a glycosylated hydroquinone found at high concentration in certain plants capable of surviving extreme and sustained dehydration. It has been reported to have an inhibitory effect of melanogenesis and to be hydrolyzed easily to yield glucose and hydroquinone by β-glucosidase. While hydroquinone also has an anti-melanogenic effect, however, is carefully used as a topical whitening agent because of side effects. The present study was undertaken to examine the inhibitory effect of an whitening agent containing arbutin and β-glucosidase on UV radiation induced pigmentation in human skin. Experimental subjects were UVB-irradiated on the back. UVB-irradiated areas were assigned to three groups: arbutin and β- glucosidase treated group, vehicle control, and no-application control. Arbutin and β-glucosidase treatment inhibited pigmentation by 50.17 percent, compared with the controls (N : 10; P < 0.05). These results suggest that the whitening agent containing arbutin and β-glucosidase may be used as an agent to inhibit melanin formation induced by UV radiation.
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신민경 ( Min Kyung Shin ),홍경국 ( Kyung Kook Hong ),유박린 ( Bark Lin Lew ),김낙인 ( Nack In Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
Microscopic polyangiitis (MPA) is a systemic vasculitis that is histologically characterized by small vessel involvement. Although MPA is primarily associated with necrotizing and crescentric glomerulonephritis and pulmonary capillaritis, MPA often has cutaneous features. We report a case of microscopic polyangiitis with acral necrosis as the skin manifestation. A 56-year-old man presented with acral dry gangrene on tip of finger and toe and reticulated erythema on leg. He had suffered from proteinuria, hemoptysis, and arthralgia. Histopathologically, small vessel vasculitis without granuloma was seen. A high serum level of pANCA was detected by ELISA. This is a relatively rare disease, which has a poor prognosis in the absence of aggressive therapy, and is infrequently reported in dermatologic journals in Korea. (Korean J Dermatol 2007;45(12):1298∼1302)
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신민경 ( Min Kyung Shin ),조태호 ( Tae Ho Cho ),유박린 ( Bark Lin Lew ),심우영 ( Woo Young Sim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
We present a case of a young male with a five year history of a hair-loss patch presenting linear distribution on the scalp. A biopsy specimen revealed a lymphocytic panniculitis and fat degeneration with mucin deposit. Focal hydropic degeneration of basal cells was also evident. Direct immuno-fluorescence revealed peribulbar granular deposits of IgM, IgA and C3. Antinuclear antibody was negative. Clinical appearance was unusual but histological examination revealed linear lupus erythematosus profundus. To our knowledge, only one other case of linear lupus erythematosus profundus on the scalp has been reported in English written literature until now. (Korean J Dermatol 2007;45(12):1280∼1283)
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