한공각화증 79예에 대한 임상 및 병리조직학적 연구

원영호,김대영,김성진,전인기 ( Young Ho Won,Dae Young Kim,Seong Jin Kim,Inn Ki Chun ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background: Porokeratosis is a rare disorder characterized by an abnormal keratinization. Five different clinical types have been described, however most reports are on a small scale and rest,ricted to a particular type. Objective : We tried to distinguish clinical and histopathologi'cal feat.ures of each type of porokeratosis. Methods: All patients with porokeratosis visiting the Dermatological Department of Chonnam University Hospital were retrospectively reviewed and finally 79 patients were evaluated. Results . Disseminated superficial actinic porokeratosis(DSAP) was most common it was present in 44 patients(56%). This was f'ollowed by the plaque type(28%), linear type(14%) and punctate type(2%). The:;oungest average age of onset was in the linear type at 13 years old (range 2-34 years old), and the oldest in DSAP which appeared in all patients after the age of 20. The plaque type was predominant in males 2.6 times rnore than in females. The predilection sites were the trunk in the plaque type, the unilateral lower limbs in the linear type and the face lower limbs in DSAP. 1tching was a complaint in 71% of DSAP and pain was in 14% of t.he plaque type. DSAP revealed a family history in 23% and a solar exacervation in 41%. Three cases of the plaque type t ad a malignant change. The average number of cornoid lamella per section was 1.8(ranging from one to seven). The height and invagination depth of cornoid lamellae were most prominent in the plaque type, and the le~ast in DSAP. Dysk(ratotic cells and vacuolar cell degenerat,ion in t.he underlying epidermis were most frequent in the plaque type. However dermal melanophage were present in DSAP. The Epidermis inside ring of:o~rnoid lamella was acanthotic chiefly in the plague type and atrophic chiefly in DSAP. Conclusion : These resuts demonstrate that each type of porokeratosis is somewhat, different in clinical and histopathological features. (Kor J Dermatol 1997;35(1): 33-40)

조갑진균증에서 Ciclopirox 8 Nail Lacquer의 치료효과

원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ),이승철 ( Seung Chul Lee ),전인기 ( Inn Ki Chun ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Background : Ciclopirox 8% nail lacquer is a new topical antifungal agent which is charact.er ized by excellent penetration into the nail plate to the infected koratin and remains there for a prolonged period. We per formed a st,udy to assess the therapeutic efficacy and safety of ciclopirox 8% nail lacquer in the treatment of onychomycoses. Methods : We used 20 satients wit,h onychomycoses, which was confirmed by KOH ancl fungus culture. The ciclopirox nail lacquer was applied once daily for 1 month, and followed by two times weekly for the next 5 months. The clinical observat.ion was perforrned every month for any clinical improvement and side-dffects. The involved percent of a target nail was measured by using a adhesive tape at.ached to the selected nail plate. All involved nails(n=68) were also evaluated by a severity score(severe>50%. moderate 25-50%, mild<25%). Results : Seventeen patients were finally assessed because of the deletion of 3 patients througl loss of contact. The involved percent of target nail was significantly decreased from 57.4% at baseline to 27.9% througli the 6 month-treatment(p<0.01, ANOVA). The total reduced precent of target nail involvement at the end of the treatment was 52+22% on average. The precent of severly involved nail(>50%) in all 68 involved nails was also decreased from 56% at baseline to 7% by the end of the treatment The mycologieal cure rate was 82.4% by the end of the treatment. The overall efficaor assessed by the physician and patients was improvement by 82.4% Tolerability was excellent or good in all patients, but cosmetic acceptance was good or excellen by 53%. Only one patient complained of a prickling sensation, but no systemic adverse effect were found, Conclusion : These data suggest that ciclopirox 8% nail lacquer may be safe and effective ir the treatment of onychomvcoses. (Kor J Dermatol 1995;33(6): 1079-1084)

Symposium 3-2-1 (SYP 3-2-1) : Severe pruritic variable papules and plaques on whole body in a 52-year-old woman

원영호 ( Young Ho Won ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

She presented with refractory pruritic variable papules plaques throughout trunk and extremities for 2 months. The past history and family history were non-specific for allergic disease, malignancy, and medication. One month ago, all lab including routine CBC, D/C, IgE, LFT, Urine analysis were normal or non-specific. On physical examination, there was localized diffuse papular rash on the body and extremities, and erythema with mild swelling on eye and ear lobe on face. The others were normal or non-specific. She has treated with antihistamine oral and injection, and oral prednisolone for about 2 weeks. However, the skin lesion and pruritus were continued. The skin biopsy from urticarial-like erythematous patch revealed mild perivascular lymphoid infiltrate, dilated capillaries and few extravasted red blood cells. The laboratory examinations of routine CBC, D/C, thyroid hormone level, ANA were normal limit except mildly an increased liver enzyme as ALT 50, AST 86. The skin lesions of the face become more edematous and focal erosive macules. The skin biopsy from a discolored lesion show that mild vacuolar degeneration of basal layer, linear hyalinization on the upper dermis.

Symposium 2-2-2 (SYP 2-2-2) : A walnut sized protruding tumor on right upper posterior thigh in 63-year-old woman

원영호 ( Young Ho Won ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

A 63-year-old women presented with a walnut-sized protruding tumor. It was first noticed as a small nodule 5 months ago, which was removed simply without any skin biopsy. However the wound had a delayed healing with continuous discharge and grow up into a larger nodule. At other clinic the recurred nodule was removed again. But, the tumor recurred again on the area as a larger nodule than before and she visits our hospital. The measurements of the tumor are roughly 5 cm wide and 6 cm long and 3cm height in size. It was erythema on the surface and peripheral skin, had a smooth surface with some white scales, and crusted lesions with mild discharge. She feels mild tender, but no pain. The two skin biopsies from the lesion reveals non-specific chronic granulomatous findings with various inflammatory infiltrate and wide-ranging fibro-collagenous proliferation. Staphylococcus aureus was cultured from discharge. She taken a complete surgical remove with split thickness skin graft from left posterior thigh, and local advanced flap, without any recur for 3 years follow-up.

피하 유피낭종 (類皮囊腫) 의 가족 2예 ( 모녀 )

원영호(Young Ho Won),김영표(Young Pio Kim) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.5

Dermoid cyst is rare developmental anomaly with sequestration of embryonic closure line, but there is no suggestian that such an anomaly is inherited. The patients were 41 year old mother and 10 year old daugliter whose skin lesions have been noticed since puberta.lstae in the mother and since birth in the daugther It was interesting for those lesions to be appeared typically on the superior orbital area.

PSCAD/EMTDC와 PSS/E를 활용한 시송전계통 과도현상 비교 및 분석

원영호(Young-Ho Won),송태용(Tae-Yong Song) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.4

피부결핵환자의 파라핀포매 조직에서 중합효소연쇄반응을 이용한 결핵균의 검출

원영호 ( Young Ho Won ),오종석 ( Jong Suk Oh ),박건 ( Keon Park ),전인기 ( Inn Ki Chun ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Background: It is well known that the cutaneous tuberculosis especially skin tuberculids is difficult to detect early and make a confirm diagnosis because the organism is seldom detected in a lesion by conventional methods such as AFB stain and culture. The polymerase chain reaction is a very powerful molecular biological tool in diagnosing infectious, neoplastic and genetic diseases. It has the merit of employing various samples, and to improving sensitivity by the modification of PCR techniques. Usage of the routinely formalin-fixed paraffin-embedded tissue as a sample for PCR is very useful in clinical examination, however the sensitivity and specificity have been known to be decreased. Objective : To evaluate the efficacy of the nested-PCR in the diagnosis of different types of cutaneous tuberculosis, we tried to detect the DNA of Mycobacterium tuberculosis from routinely formalin-fixed paraffin-embedded tissue. Methods : The various cutaneous tuberculosis and infectious granulomatous disease were retrospecitively selected by the findings of clinical, histopathological and bacterial culture. There were 9 cases of lupus vulgaris, 4 tuberculosis verrucosa cutis, 2 papulonecrotic tuberculid, 2 erythema induratum and 4 lupus miliaris disseminatus faciei. To amplify the 123bp DNA fragment of a repeated insertion sequence IS6110, two pairs of primers composing outside and inside primers were applied. Results : The positive band was found in 10(91% ) of lupus vulgaris, 3 of tuberculosis verrucosa cutis, 1 papulonecrotic tuberculid and 1 erythema induratum. Four of the LMDF and 5 of the infectious granulomatous diseases were negative. Conclusion : The nested-PCR using routinely formalin-fixed paraffin-embedded tissue is a useful diagnostic tool if combined with the result of other clinical data. Also it may provide further insight into pathogenesis of skin tuberculids and the differential diagnosis of granulomatous skin diseases. (Kor J Dermatol 1996;34(1): 64-70)

최근 10년간 악성흑색종의 임상 및 병리조직학적 연구

원영호(Young Ho Won),허수경(Soo Gyoung Hur),이승철(Seung Chull Lee),전인기(Inn Ki Chunn),김영표(Young Pio Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.2

A total of 39 malignant melanoma cases diagnosed at Chonnam National University Hospital for past 10 years from 1980 to April, 1990 were included for the clinicopathologic study. Among the 29 primary cutaneous melanomas, 18 cases(62.1 % ) occurred on the hands and the feet, especially on the heel. The average age of the patients was 54.3 years at the time of diagnosis and the male to female ratio was 1 to 1,4. Acral lentiginous melanoma was the most common (h2.1% ) histopathologic type and the invasion level c)f 22 cases(78.4% ) was over 1.50mm by Rreslows thickness. (Kor J Dermatol 29(2):193 202)

흄관 매설 자동화 장비 개발을 위한 기술적ㆍ경제적 타당성 분석에 관한 연구

원영호(Won Young Ho),손석호(Son Seok Ho),김영석(Kim Young Suk),이준복(Lee Jun Bok) 대한토목학회 2002 대한토목학회논문집 D Vol.22 No.6D

Vibrio vulnificus가 분비하는 Cytolysin의 독성기전

원영호(Young Ho Won),김영표(Young Pio Kim),김형로(Hyung Rho Kim) 대한피부과학회 1989 大韓皮膚科學會誌 Vol.27 No.5

The extracellular cytolysin produced by V. ulnificus has gained great attention as a causative factor for the pathogenesis of V. vulnificus-infected disease. In this study, an attempt was made to elucidated the mechanism for the toxity of cytolysin. 1. Cytolysin given to mouse showed lethal activity with LD of 3.7 HU and produced hemoconcentration, suggesting that its lethal activitis attributable to the increased vascular permeability. 2. The lethal activity of cytolysin for mouse was prevented by intraperitoneal administration of clemastin or verapamil one hour before intravenous injection of cytolysin. 3. Treatment of peritoneal mast cells from rats with cytolysin stimulated histamine relesse irrespective of the prescence of extracellular Ca and the stimulatory effect of cytolysin was not affected by the pretreatment of mast cells with per tussis toxin. 4. The hemolytic activity and stimulatory effect of cytolysin on histamine release from mast cell were inhibited by cholesterol. The results suggest that the lethal activity of cytolysin is attributable to the increased vascular permeability which is resulted from the stimulation of histsmine release from mast cells and/or basophils by cytolysin.