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항암제 전달을 위한 독소루비신이 충진된 핵/쉘 나노입자
오근상,엄윤식,구형모,조선행,육순홍 한국생체재료학회 2008 생체재료학회지 Vol.12 No.1
Doxorubicin-loaded core/shell nanoparticles were prepared and characterized as a drug delivery system. The lipid core is composed of lecithin and polymeric shell is composed of Pluronic (poly(ethylene oxide)-poly(propylene oxide)- poly(ethylene oxide) triblock copolymer, F-68). Freeze-drying of doxorubicin-loaded lipid core was performed in the F-68 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of core/shell nanoparticles and electrophoretic light scattering was used to observe the particle size and zeta potential. Doxorubicin was loaded into the core/shell nanoparticles by ionic interaction and sustained release of loaded doxorubicin was observed.
용매 증발법에 의한 나노 입자 제조 및 아토바스타틴 칼슘의 효과적인 약물전달체로의 응용
오근상,오상권,김동민,육순홍 한국생체재료학회 2010 생체재료학회지 Vol.14 No.1
Atorvastatin calcium-loaded polymeic nanoparticles were prepared and characterized as a delivery system for hydrophobic drugs. For this purpose, pluronic (poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-68)-based polymeric nanoparticles were prepared by solvent evaporation process. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of polymeric nanoparticles and electrophoretic light scattering was used to observe the particle size. For the application as an efficient delivery system for atorvastatin calcium, the stability of nanoparticles and release profile was observed in the phosphate buffered solution (pH 7.4).
오근상,송지영,김동민,육순홍 한국생체재료학회 2009 생체재료학회지 Vol.13 No.4
Doxorubicin-loaded polymeic nanoparticles were prepared and characterized as a pH-sensitive drug delivery system. For this purpose, doxorubicin-loaded pluronic (poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-68) micelles were stabilized with glycol chitosan/heparin composite. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of polymeric nanoparticles and electrophoretic light scattering was used to observe the particle size. For the application as a pH-sensitive drug delivery, the release profile of doxorubicin was observed in response to environmental pH change.