CD99 activates T cells via a costimulatory function thatpromotes raft association of TCR complex and tyrosinephosphorylation of TCR ζ

오권익,Young Larn Ban,최은영,정경천,이임순,박성회,Byoung Kwon Kim 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.2

We investigated the co-stimulatory role of a cellsurface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR ζ-mediated signal 1. These data demonstrate the unique pro - perties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident costimulatory factors.

Sepsis Mortality in CIITA Deficient Mice is Associated with Excessive Release of High-mobility Group Box 1

오권익,김지영,김지현,서재남 대한면역학회 2008 Immune Network Vol.8 No.2

Background: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model. Methods: Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression. Results: Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Conclusion: Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release. Background: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model. Methods: Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression. Results: Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Conclusion: Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release.

Expression Pattern of Immunoproteasome Subunits in Human Thymus

오권익,서재남 대한면역학회 2009 Immune Network Vol.9 No.6

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes. The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.

작명(作名) 관련 가정의례(家庭儀禮) 고찰

권익기(權益棋) 원광대학교 원불교사상연구원 2023 원불교사상과 종교문화 Vol.98 No.-

Family rites are performed rites by family in each important turning point of family members. Even though it is known as Gwanhonsangje, traditionally, there is also Tonglye like Yusajeuggo. Today, both Suyeonlye and Jagmyeonglye are also included. Name specifically identifies a person, has identitis, and naming has the meaning of social birth. As an important turning point of our lives, it has been an object of family rites from the past, so this thesis examined this. As the family rites related to naming, traditionally, there was Jagjarye included in Gwanlye. From the 1990s, Jagmyeonglye has also been carried out. Gwanlye which was the traditional coming of age ceremony included Jaseol and Jagmyeonglye of Ja. Even after Gwanlye was settled down in the early 16th century, it was carried out only by some of the upper class. Due to the early marriage and Danballyeong, Gwanlye gradually disappeared in the Japanese colonial era. However, because of the strong educational feature for getting equipped with adult’s character, it was revived as coming of age ceremony in 1999. However, separately from this, after the enforcement of Minjeogbeob, Gyeongmyeongsasang and Pihwi disappeared, and along with the disappearance of ja, Jagjarye also disappeared. Jagmyeonglye is the family rites that name a Bonmyeong to a young child. The history is long enough to be recorded in Jujagarye and traditional Garyeseo. Even though it is argued to be carried out in the Joseon Dynasty, it has not been verified. From the 1990s, Jagmyeonglye was included in family rites, which has still rarely been carried out yet. Jagmyeonglye, which includes both physical birth and naming was an important turning point of our lives, so it was an object of family rites. Therefore, it should be highly evaluated that Jagmyeonglye was included in family rites based on Garyeseo. For the vitalization of Jagmyeonglye, we also need modernization of Myeongcheob and detailed records of naming methods.

일본 신문광고 캐치카피의 기호학적 분석에 관한 연구

권익호(權益湖),송숙정(宋淑正) 중앙대학교 일본연구소 2013 日本 硏究 Vol.0 No.34

This study verified through the used sentences whether the word ‘日本", employed in the catchphrases in Japanese newspaper advertisements, plays the role of a linguistic sign with connotations. As a result, it is known that the connotation of the word ‘日本" serves as an ideological subject to be protected, saved and safeguarded, identified with the world as the supreme value, getting beyond Japan and the image based on the national value. The research further shows that ‘日本’ implies a stronger connotation when pronounced as ‘にっぽん’ than when pronounced as ‘にほん’, and in a sentence in which the state ideology of nationalism is strongly expressed, ‘日本 is pronounced as ‘にっぽん". The study also shows that the word ‘日本’ as a linguistic sign has developed into a myth through the interaction with the signs connected with each other.

중화상 환자들에서 Western Blot 분석에 의한 골격근 니코틴성 아세틸콜린 수용체 아단위들의 변화: 화상 대 비화상 부위

오권익,김태운,장현묵,곽인숙,한태형,김광민 대한마취과학회 2005 Korean Journal of Anesthesiology Vol.48 No.6

仮定条件と反語的意味に関する小考

권익호(權益湖),김창휘(金昌輝) 중앙대학교 일본연구소 2009 日本 硏究 Vol.0 No.26

한․일 제과 브랜드명에 대한 연구 -조어(造語)를 중심으로-

권익호,윤사연 한국일본근대학회 2010 일본근대학연구 Vol.0 No.29

신문에 나타난 일본어 표현에 관한 고찰― 일본어 투 조사(助詞)를 중심으로

권익호,이선화 중앙어문학회 2019 語文論集 Vol.80 No.-

The central purpose of the current paper is to examine how Japanese style postpositions, sometimes called ‘particles’. have been used and changed in the Korean language. A set of six postpositions were selected for that purpose: ‘-kwaeuy’, ‘-e isseo(seo)’, ‘-eseoeuy’, ‘-robuteo’, ‘-roeuy’, and ‘–roseoeuy’. The data under analysis were collected from five national papers including Chosun Ilbo, Joongang Ilbo, Donga Ilbo, Hankuk Ilbo, and Seoul Daily. A total of 20,000 sentences were used for analysis: 1,000 sentences from each paper at four different times –the 1990’s, the 2000’s, the 2010’s and 2019. It was found that the postposition ‘–kwaeuy' topped the list of frequency at all the four different times followed by ‘–eseoeuy', ‘-robuteo', ‘-e isseoseo', ‘-roseoeuy' and ‘–roeuy'. In terms of diachronic differences, the greatest gap was found between the 1990’s and the 2000’s. Overall, the use of Japanese style postposition has decreased significantly in 2019 compared to 1990s; therefore, the awareness in Korean language purification seems to have increased in medias. It was also found that there existed a big difference in the frequency of use of these postpositions between Seoul Daily(169) and Hankuk Ilbo(93). Chosun Ilbo marked the greatest rate of reduction, 91%, between the 1990’s and 2019. 본 연구는 한국어에 잔재하는 일본어 표현 중 일본어라는 의식이 희박한 일본어 투 조사(助詞)의 사용실태 및 시대별 사용양상에 대하여 국내의 주요 신문을 대상으로 고찰한 것이다. 일본어 투 조사 중 (1)‘-과(와)의’, (2)‘-에 있어(서)’, (3)‘-에서의’, (4)‘-(으)로부터’, (5)‘-로의’, (6)‘-(으)로서의’의 6가지를 선정하고, 실태 분석을 위해 조선일보, 중앙일보, 동아일보, 한국일보, 서울신문 등 5개 언론사의 신문기사를 시대별(1990년대, 2000년대, 2010년대, 2019년도)로 각 1,000문장씩 발췌하여 그 속에서 사용된 일본어 투 조사의 수를 조사하였다. 고찰 결과, 조사별로는 모든 연도에서 ‘-과(와)의’의 사용횟수가 가장 높았고, 그다음으로 ‘-에서의’, ‘-(으)로부터’, ‘-에 있어(서)’, ‘-(으)로서의’, ‘-로의’의순으로 일본어 투 조사가 많이 사용되었다. 시대별로는 1990년대와 2000년대의 10년 사이에 가장 큰 감소율을 보인 것이 특징적이다. 전체적으로 1990년대와 2019년도를 비교하면 눈에 띄게 일본어 투 조사의 사용이 줄어 각 언론사에서는 일본어 투 조사 표현에 대하여 국어순화 의식이 높아진 것으로 보인다. 신문사별로는 일본어 투 조사를 가장 많이 사용한 서울신문의 169회와 가장 적게 사용한 한국신문의 93회가 극명한 차이를 보였으며, 조선일보는 1990년대에 비해 2019년도 현재까지 사용률이 크게 떨어져 5개 신문사 중 가장 많이 감소했다.

인명의 종류 고찰 - 역사와 유형별 종류, 논란을 중심으로 -

권익기 고려대학교세종캠퍼스 한국학연구소 2022 한국학연구 Vol.82 No.-

본고는 우리의 인명을 근본 유형의 본명과 자, 호 유형의 호와 별명, 당호, 택호, 시호, 필명, 예명, 그리고 근본·호 이외 유형의 태명과 아명, 아이디, 닉네임, 교명, 보명 등으로 나누어서, 역사적 전개과정과 유형별로 구분하여 모든 종류를 검토하면서 관련 논란 내용까지 살폈다. 1909년 민적법 시행 이후 모든 국민이 두 글자 한자 본명 등 모든 인명을 가질 수 있지만, 그 때까지도 하층과 대부분의 여성은 아명 밖에 없었다. 본명의 경명사상으로 부명인 자가 생겼고, 본명과 자의 별칭으로 생긴 호에서 당호와 택호, 필명, 예명 등이 분화되었다. 해당 생애주기에 따라서 태명과 아명을 지었고, 특정 용도에 사용하기 위한 별명과 교명, 보명도 생성되었다. 본명과 호, 별명과 같이 오랜 기간 사용 중인 인명도 있지만, 전통적인 자와 시호는 이미 사라졌고, 아명과 당호, 택호는 멀지 않아 사라질 수도 있다. 논란 내용 중 본고에서 확인된 사항은 첫째, 冠名(관명)이란 성인 이전을 제외한 이후만의 본명을 지칭하므로 본명의 동의어가 아니다. 둘째, 항렬자 사용이 일반화된 기간은 근년이면서 오랜 기간도 아니고 오래전일수록 일부만 항렬자를 사용하였기에, 본명의 전통적인 작명을 항렬자 사용 여부로만 구분하는 것은 재고해야 된다. 셋째, 당호는 두 번째로 많은 호의 작명 유형이고, 필명은 생성 요인과 작명 유형이 호와 거의 동일하므로 지나친 호의 유형 분류는 옳지 않다. 넷째, 본명에서 별명이 분화되어 다명사회가 된 후, 인명은 소멸보다 더욱 다양하게 생성 분화되었으므로 일명사회로 돌아갈 수는 없다. 다섯째, 아명은 어린 아이의 애칭일 뿐 공부상 인명이 아니므로 본명을 성인 이전의 아명과 이후의 冠名으로 구분할 수 없다.