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안병진 建國大學校 經濟經營硏究所 1998 商經硏究 Vol.23 No.2
Two problems which often plague researchers using regression techniques are multicollinearity and nonnormal error distributions. A number of authors have proposed robust regression procedure that are robust to nonnormal error distributions and have suggested biased estimation methods for multicollinearity problem. Although we usually think of there two problems separately, in a significant number of practical situations nonnormality and multicollinearity occur simultaneously. Since robust regression estimates are frequently unstable when the design matrix is ill-conditioned, it would be desiable to have a technique for dealing directly with both problems. Askin and Montgomery(1980) discuss augmented robust estimators as a way of combining biased and robust regression techniques. Based on this idea, this paper suggests the robust versions of Nonnegative Garrot and Lasso. It seems necessary that Monte Carlo study be done to compare the performance of the various type of robust biased estimators.
로지스틱 모형에서 변수선택에 영향을 미치는 관측값에 대한 연구
안병진 建國大學校 經濟經營硏究所 1994 商經硏究 Vol.19 No.1
As is the case in linear regression, model fitting via logistic regression is also sensitive to influential cases. The values of statistic used for variable selection criteria can be reduced remarkably by excluding only a few influential cases. Furthermore, different subsets of explanatory variables change the influence patterns for the same response variable. Leger and Altman(1993) introduce a statistic, namely unconditional Cook's distance, to assess the influence of each case on the variable selection procedure. We adopt same idea to logistic model and obtain an unconditional likelihood distance for the detection of influential cases. And some variable selection criteria for logistic model are also discussed.
안병진,임동석 대한임상약리학회 2008 Translational and Clinical Pharmacology Vol.16 No.2
Biotech drugs which have been approved since 1980’s take a major portion in the pharmaceutical industry with increasing number of drugs in the market. Because ADME of biotech drugs differ from that of small molecules, many of the drugs show non-linear pharmacokinetic behaviors and PK analysis using non-compartmental methods may also give misleading parameter values. As macromolecules, the distribution may be confined to the extracellular space, however, receptor mediated endocytosis and circulation through lymphatic vessels may change the distribution profile. Another uniqueness in the PK of biotech drugs is that the drug targets (receptors) act as an elimination mechanism of the drug. Therefore, the elimination may be influenced by the effect (pharmacodynamics) of drugs and vice versa. In the development of biotech drugs, mechanism based PK-PD modeling based upon the understanding of such unique characteristics will be helpful to avoid mistakes in the clinical trial design. Biotech drugs which have been approved since 1980’s take a major portion in the pharmaceutical industry with increasing number of drugs in the market. Because ADME of biotech drugs differ from that of small molecules, many of the drugs show non-linear pharmacokinetic behaviors and PK analysis using non-compartmental methods may also give misleading parameter values. As macromolecules, the distribution may be confined to the extracellular space, however, receptor mediated endocytosis and circulation through lymphatic vessels may change the distribution profile. Another uniqueness in the PK of biotech drugs is that the drug targets (receptors) act as an elimination mechanism of the drug. Therefore, the elimination may be influenced by the effect (pharmacodynamics) of drugs and vice versa. In the development of biotech drugs, mechanism based PK-PD modeling based upon the understanding of such unique characteristics will be helpful to avoid mistakes in the clinical trial design.
쿠바 미사일 위기와 베를린 가설: 케네디의 개념틀에 대한 비판적 고찰을 중심으로
안병진 한국사회과학연구회 2011 동향과 전망 Vol.- No.81
‘쿠바 미사일 위기’란 1962년 10월 15일 미국의 U-2 정찰기가 쿠바 섬에서 소련 중거리 미사일을 발견함으로서 미국이 소련 및 쿠바와 3차 대전 직전까지 가는 심각한 위기 상황에 직면했던 사건을 말한다. 이 사건은 이후 외교 정책론의 이론적 발전에 많은 영감을 준 풍부한 의사결정 과정의 사례를 제시해주고 있다. 이 글의 목적은 쿠바 미사일 위기에 대한 일반적 평가를 넘어 최근 새로이 해제된 미국과 소련의 비밀문서 및 증언을 토대로 ‘비판적 구두 역사’(critical oral history) 방법론을 동원하여 당시 케네디 행정부의 내부 논쟁과 판단에 대해 살펴보는 데 있다. 특히 이 글의 초점은 케네디의 주요 사고의 틀인 ‘베를린 프레임’의 적실성 문제를 인지 심리학의 관점에서 지적하고자 한다. 이 논문의 주요 주장은 케네디가 소련의 쿠바 미사일 배치를 베를린 장악 목표와 연결하여 사고한 것은 베를린 방어를 중심으로 모든 것을 해석하는 자신의 자의적 사고틀과 그 근저에 있는 전략적 합리성 관점의 제약, 뮨헨 사태 등으로 인한 자신의 외상적 기억 등이 종합적으로 만들어낸 오류라고 주장한다. 국제적 위기 상황에서 공산주의 정부에 대한 미국 지도자의 인지적 틀의 한계에 대한 연구는 의사 결정론의 이론적 심화는 물론 오늘날 한반도의 핵 위기에 대한 중요한 시사점을 던져줄 수 있다. Why did the Soviet deploy ballistic missile to Cuba? This question has been one of the greatest puzzles in the generations of international relation scholars for several decades. Based on the recently declassified documents, this paper seeks to shed new lights on the Soviet motivation debate. In particular, employing ‘critical oral history’ approach, this paper challenges the ‘Berlin hypothesis’ in Kennedy and Allison’s interpretation of Soviet motive during ‘Cuban missile crisis’.