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RISS 인기검색어
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- 저자 : 안덕근 ( Duck Gun An ) (검색결과 3 건)
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안덕근 ( Duck Gun An ),황지혜 ( Ji Hye Hwang ),정진호 ( Jin Ho Jeong ) 대한면역약침학회 2015 대한면역약침학회지 Vol.4 No.2
Objectives : We developed new Yakchim M (MY) for activation of brain function and inhibition of inflammation with complex herbal extract including Gastrodiae Rhizoma, Cynanchi Wilfordii Radix, Polygalae Radix, Acori Graminei Rhizoma, Aucklandiae Radix, and Aquilariae Lignum and investigated the pharmacological activities and cell toxicity of MY. Methods : The anti-oxidant effect of MY was investigated by determining 2,2-diphenyl-1-picryl hydrazyl (DPPH) free radical scavenging activity. We investigated for the anti-inflammatory effect of MY, LPS-induced nitric oxide (NO) production in RAW 264.7 cells. Also We investigated cell toxicity of MY, cell viability of MY on RAW 264.7 cells using MTT assay. Results : MY showed dose dependent DPPH radical scavenging rate and inhibitory effect of LPS-induced nitric oxide (NO) production in RAW 264.7. and MY (1 mg/ml) did not show cell toxicity in the MTT assay. Conclusions : These results suggested that MY has anti-oxidant, and anti-inflammatory activities. However, more efficacy and safety studies are needed for the development of MY as a medicinal preparation on brain function improvement and anti-inflammation.
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정철 ( Chul Jung ),안덕근 ( Duck Gun An ) 대한면역약침학회 2014 대한면역약침학회지 Vol.3 No.1
Objectives : The purpose of this study was to determine the mutagenic potential of CA-YAKCHIM using histidine requiring Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and tryptophan requiring Escherichia coli (WP2uvrA(pKM101)) strains in the absence and presence of metabolic activation. Methods : In order to determine the dose levels of the main study, the dose range finding study was performed first. The high dose was selected at 5,000 μg/plate and it was sequentially diluted by the geometric ratio of 4 to 1,250, 313, 78.1, and 19.5 μg/plate. As a result, the growth inhibition by the CA-YAKCHIM was not evident at any dose levels in the absence and presence of metabolic activation. Therefore, the dose levels of the main study were selected as 313, 625, 1,250, 2,500, and 5,000 μg/plate. And the negative (acetone) and positive (sodium azide, 2-Nitrofluorene, 9-Aminoacridine, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, and 2-Aminoanthracene) control groups were used. Results : The mean number of revertant colonies was less than twice when compared to the negative control values at all dose levels of the CA-YAKCHIM in the presence and absence of metabolic activation, without dose-related increase. In the positive control group, the number of revertant colonies was markedly increased when compared to that of the negative control group. Conclusions : In this bacterial reverse mutation test, CA-YAKCHIM did not exhibit any indications of mutagenic potential.
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양재원 ( Jae Won Yang ),안덕근 ( Duck Gun An ) 대한면역약침학회 2015 대한면역약침학회지 Vol.4 No.1
Objectives : This study evaluated the potential related CSⅡ-YAKCHIM on chromosomal aberrations in Chinese Hamster Lung (CHL/IU) cells to provide the safety evidence of CSⅡ-YAKCHIM. Methods : In order to determine the high dose levels of the main study, the cell growth inhibition study was conducted. The high dose was selected at 5,000 μg/mL and it was sequentially diluted to produce lower dose levels of 39.1, 78.1, 156, 313, 625, 1,250 and 2,500 μg/mL. As a result, the cell growth inhibition was below 50% at all dose levels when compared with negative control value in the short time treatments without and with metabolic activation and the continuous treatment without metabolic activation. Therefore, the dose levels of the main study were selected as 1,250, 2500, and 5,000 μg/mL (short time treatment and continuous treatment). Also, the negative and positive control groups were used. Results : As a result of the main study, the frequency of cells with chromosome aberrations was less than 5% in the short time treatments without and with metabolic activation and the continuous treatment without metabolic activation. Also, there was no statistically significant differences when compared to that in the negative control group. In the positive control group, the frequency of cells with structural chromosomal aberrations was more than 10% and statistically significantly increased compared to that in the negative control group. Conclusions : Based on the results of this study, CSⅡ-YAKCHIM did not exhibited the chromosome aberrations under the conditions of this study.
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