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Carbon-based drug delivery carriers for cancer therapy
임동진,심명부,오이슬,임경희,박한수 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
In the search to improve anticancer therapies,several drug carriers, including carbon-based nanomaterialshave been studied. Both liposomes and polymericmicrospheres have been used in anticancer drugs. However,there remains an on-going need for better therapeuticmaterials that have good drug solubility, an ability toreduce systemic toxicity through specific-tumor targeting,and rapid clearance. In this regard, carbon allotropes suchas graphene oxide (GOs), carbon nanotubes (CNTs), andnanodiamonds (NDs), have been investigated, as theypossess sufficient surface-to-volume ratio, thermal conductivity,rigid structural properties capable of postchemicalmodification, and excellent biocompatibility. This review is aimed at exploring these carbon-basednanomaterials for use as multifaceted cancer drug carriersand is intended to demonstrate that GOs, CNTs, and NDsare likely to improve chemotherapeutical strategy forcancers in either a sole or combinational manner.
임동진,박한수,심명부,허윤회,전호욱 한국고분자학회 2015 Macromolecular Research Vol.23 No.12
Electrospinning is a technique that has been widely utilized to create nanofibrous scaffolds that mimic the cellular environment. Scaffold fabrication using the conventional electrospinning technique is cost-effective and simple. However, this method is slightly problematic in terms of creating a well-defined structure. To create a uniformly patterned and porous nanofibrous scaffold, in this study, we utilized an easy module consisting of a patterned watersoluble film placed on the top of a conventional collector. Scaffolds fabricated with either poly(lactide-co-glycolide) (PLGA) or poly(ε-caprolactone) (PCL) were seeded with human adipose-derived stem cells (hASCs), and evaluated for cellular proliferation. The patterned and porous nanofibrous scaffolds facilitated significantly better hASC proliferation compared to scaffolds prepared using a conventional collector apparatus. Enhanced hASC proliferation was confirmed by total cellular proliferation activity evaluation and scanning electron microscopy (SEM). These results indicate that the facile method described in this study would be promising for preparation of patterned and porous nanofibrous scaffolds for a variety of tissue engineering applications.