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活絡丹 전탕액이 Hydrogen Peroxide에 의해 손상된 배양 척수감각신경세포의 LDH 활성도에 미치는 효과
송왕기,권강범,이호승,김희찬,김우경,오광수,안효창,류도곤 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.3
To evaluate the effect of Hwalrak-dan(活絡丹) water extract on cultured mouse spinal sensory neuron which was inhibited by hydrogen peroxide(H2O2)-induced oxygen radicals, NR assay and LDH activity assay were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of Hwalrak-dan water extract for 3 hours prior to exposure of hydrogen peroxide. The results were obtained as follows : H2O2, a oxigen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on NR assay and MCV of H2O2 was 40μM H2O2. Hwalrak-dan have efficacy of decreasing significantly LDH activity increased by H2O2 in cultured mouse spinal sensory neuron cells. From above the results, it is concluded that Hwalrak-dan has marked efficacy as a treatment for the damages caused in the H2O2-mediated oxidative process. Further clinical study of this pharmacological effects of Hwalrak-dan should be complemented.