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Brine Shrimp Bioassay를 이용한 해양생물의 세포독성검색
손병화(Byeng Wha Son),조용진(Yong Jin Cho),이대령(Dae Ryoung Yi),노연숙(Yeon Suk Roh),이선미(Sun Mi Lee),최홍대(Hong Dae Choi) 대한약학회 1993 약학회지 Vol.37 No.5
As a part of chemical study on the bioactive metabolites from marine organisms, we have investigated cytotoxicity using brine shrimp bioassay for each solvent fractions of the marine algae(12 species), marine sponges(3 species), coelenterates(2 species), echinoderms(4 species), marine molluscs(17 species), and ascidians(2 species), respectively. As the results, chloroform extract of Stichopus japonicus (LC50 : 274 mcg/ml), ethyl acetate extract of Anthocidaris crassispina(LC50 : 121mcg/ml), n-butanol extract of Undaria pinnatifida (LC50 : 178mcg/ml), and water extract of Thais clavigera (LC50 : 61mcg/ml) displayed the most significant cytotoxic activity against brine shrimp. Among the marine organisms tested, echinoderms and marine molluscs were thought to be the most active Phylums on screening of new bioactive compounds.
홍조 꼬시래기(Gracilaria verrucosa) 유래의 글리세로당 Floridoside의 화학구조
노연숙,손병화,임광식,최홍대,Roh, Yeon-Suk,Son, Byeng-Wha,Im, Kwang-Sik,Choi, Hong-Dae 한국생약학회 1994 생약학회지 Vol.25 No.2
As part of search for new biologically active substances from marine organism, we have isolated a glyecrol glycoside from the marine red alga Gracilaria verrucosa. The structure of the glycerol glycoside was elucidated as 2-O-${\alpha}-_D$-galactopyranosylglycerol[floridoside(4)] on the basis of spectroscopic and physicochemical evidences.
조용진,정동윤,최홍대,박종희,손병화,Cho, Yong-Jin,Jeong, Dong-Youn,Choi, Hong-Dae,Park, Jong-Hee,Son, Byeng-Wha 한국생약학회 1998 생약학회지 Vol.29 No.3
Two isoflavonoids were isolated from the flowers of Pueraria lobata (Flos puerariae) guided initially fractionation based on brine shrimp lethality assay. The structures were identified as 4',5,7-trihydroxy-6-methoxyisoflavone (tectorigenin) and 4',7-dihydroxy-6-methoxyisoflavone (glycitein), respectively, on the basis of their spectroscopic and physicochemical evidences.