Linoleic acid 함량과 ω6/ω3 비율이 침수속박 스트레스에 의한 위궤양의 발병에 미치는 영향

변기원,김창임,최혜미 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.2

This study was designed to determine the effects of linoleic acid contents and ω6/ω3 ratios on the induction of gastric ulcer by water immersion and restraint stress. Sprague-Dawley rats were fed 5 diets containing 7% fat (w/w) for 6 weeks. These diet groups were Lh, Mh, Hh, Mm, Ml, :3 different linoleic acid levels(0.3% of energy(L), 3.5(M), 10(H)) and 3 different ω6/ω3 ratios(11(l), 33(m), 100(h)) with beef tallow, sunflower or fish oil. The Lh group showed a significantly higher ulcer index (UI) than the Mh and Hh groups(p<0.05). At the same linoleic levels, the UI had no significant difference within the ω6/ω3 ratios. The Mh group showed significantly higher(p<0.05) PGE₂ and TBX₂ content than any other group. Pearson's correlation coefficients between UI and PGE₂ and TBX₂ had a negatively significant correlation(p<0.05). Linoleic acid of gastric mucosal phospholipids was reflected by the diet, but was not significantly different. The most significant finding of this study is that not only the absolute amount of linoleic acid, but also the ω6/ω3 ratios are important factors for the prevention of gastric ulcer.

뇌 발달과 뇌의 Phospholipid 및 Cholesterol 의 변화

변기원,최혜미 ( Ki Won Byun,Hay Mie Choi ) 생화학분자생물학회 1982 BMB Reports Vol.15 No.3

A quantitative restriction of maternal diet was given to Sprague-Dawley rats during lactation. Animals were seperated into two groups, control and deficient groups. And 30 g of diet during lactation was given to deficient group. All the offsprings were weaned at 3 weeks of age and fed a diet ad libitum for 4 weeks of rehabilitation. Body and brain weight, brain DNA, protein, phospholipid, cholesterol were determined on offsprings of each group randomly sacrificed at 0, 1, 2, 3, 5 and 7 weeks of age. Body and brain weight of offsprings of deficient group were significantly lower than the control group. Their deficits were the largest at 3 weeks of age. After a recovery period, body and brain weights were almost to normal weight but these values were still lower than the control. Brain DNA, protein, phospholipid and cholesterol content of deficient group was lower than the control group. In spite of nutritional rehabilitation after weaning, their contents were not recovered completely. DNA, protein and lipid syntheses in the brains of deficient group were delayed by malnutrition.

LoG Scale-Space를 이용한 라인의 중심축 검출

변기원,남기곤,주재흠,Byun, Ki-Won,Nam, Ki-Gon,Joo, Jae-Heum 한국융합신호처리학회 2010 융합신호처리학회 논문지 (JISPS) Vol.11 No.3

In this paper we propose a detection method of the medial axis of the continuous stripes on the LoG scale-space. Our method detects the medial axis of continuous stripes iteratively by varying the scale of LoG operator. Small-scale LoG operator detects two +/- pole pairs centered on the edge positions of stripe by the zero-crossing detection. The more increase the scale of LoG scale-space, the more close two poles to the medial axis of stripe. The medial axis of continuous stripe is the position where two poles is overlapped. The proposed method detected robustly the medial axis of continuous stripes stronger than the thinning methods used to binary image.

식품영양과에 입학한 여대생의 식습관과 식태도의 연도별 비교 : 2003~2006년

변기원,강현주 한국식품영양학회 2009 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2009 No.06

능동 스테레오 비젼을 이용한 실내환경의 3차원 형상 재구성 알고리즘

변기원,주재흠,남기곤,Byun, Ki-Won,Joo, Jae-Heum,Nam, Ki-Gon 한국융합신호처리학회 2009 융합신호처리학회 논문지 (JISPS) Vol.10 No.1

In this paper, we propose the 3D shape reconstruction method that combine the mosaic method and the active stereo matching using the laser beam. The active stereo matching method detects the position information of the irradiated laser beam on object by analyzing the color and brightness variation of left and right image, and acquires the depth information in epipolar line. The mosaic method extracts feature point of image by using harris comer detection and matches the same keypoint between the sequence of images using the keypoint descriptor index method and infers correlation between the sequence of images. The depth information of the sequence image was calculated by the active stereo matching and the mosaic method. The merged depth information was reconstructed to the 3D shape information by wrapping and blending with image color and texture. The proposed reconstruction method could acquire strong the 3D distance information, and overcome constraint of place and distance etc, by using laser slit beam and stereo camera.

식품영양과 신입 여대생의 식습관과 식태도의 연도별 차이(2003~2008)

변기원 한국식품영양학회 2009 한국식품영양학회지 Vol.22 No.4

This study was conducted to investigate the annual differences in food habits and dietary attitudes of new female college students enrolled in the department of food and nutrition for 6 years by questionnaire. The results were as follows: age, height, weight and body mass index(BMI) were no significant annual differences over study period. The average ratios of underweight, normal weight and above overweight groups classified by the BMI standard were 19.4%, 64.4% and 16.2%, respectively. There were no significant annual differences in the scores of food habits and dietary attitudes. The intake of milk showed the lowest scores among all the food habit items and the same annual tendencies for 6 years. Among food groups items, the mean intake scores of milk(p<0.01), fats and oils(p<0.001) and vegetables(p<0.05) differed significantly by year. Specifically, the intake scores of milk and vegetables decreased gradually throughout the study period and were significantly lower in 2008 than in 2003. Among dietary habits, the mean intake scores of sweets were significantly lower in 2003 and 2007 than in other years(p<0.001), and the mean intake scores of instant frozen foods were significantly higher in 2006 than during other years(p<0.05). The sum of health related items in 2007 was significantly lower than those during other years, and this was likely due to the lowest scores both of eating-out and alcohol intake in 2007 than in other years. Among dietary attitudes, the mean score of item ' Price of food is more important than nutrition.' was significantly lower in 2005(p<0.05). Food habit scores showed significantly positive correlation with dietary habits(r=0.733, p<0.01), food groups related habits(r=0.720, p<0.01), lifestyle related disease related habits(r=0.518, p<0.01), health related habits(r=0.422, p<0.01). Food habits and dietary attitudes showed highly significantly positive linear correlations each other(r=0.426, p<0.01). Dietary habits and food groups related habits showed highly significantly positive linear correlations(r=0.366, p<0.01). These results showed the same annual tendency with respect to food habit and dietary attitudes in newly enrolled college female students for 6 years. It is expected that food habit and dietary attitudes will be improved if systemic and proficient nutrition education is provided during their college period.

Linoleic acid 함량과 $omega6/$omega3$비율이 침수속박 스트레스에 의한 위궤양의 발병에 미 치는 영향

변기원,김창임,최혜미 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.2

This study was designed to determine the effects of linoleic acid contents and $\omega$ 6/$\omega$3 ratios on the induction of gastric ulcer by water immersion and restraint stress. Sprague-Dawley rats were fed 5diets containing 7% fat(w/w) for 6weeks. These diet groups were Lh, Mh, Hh, Mm, Ml, : 3 different linoleic acid levels(0.3% of energy(L). 3.5(M), 10(H) and 3 different $\omega$6/$\omega$3 ratios (11(1), 33(m), 100(h) with beef tallow, sunflower or fish oil. The Lh group showed a significantly higher ulcer index (UI) than the Mh and Hh groups(p<0.05). At the same linoleic levels, the UI had no significant difference within the $\omega$6/$\omega$3 ratios. The Mh group showed significantly higher (p<0.05) PGE2 and TBX2 content than any other group. Pearson's correlation coeffcients between UI and PGE2 and TBX2 had a negatively significant correlation(p<0.05). Linoleic acid of gastric mucosal phospholipids was reflected by the diet, but was not significantly different. The most significant finding of this study is that not only the absolute amount of linoleic acid, but also the $\omega$6/$\omega$3 ratios are important factors for the prevention of gastric ulcer.

영유아를 위한 올바른 이유식 관리 (이유식의 중요성)

변기원 한국식품영양학회 2010 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2010 No.06

경기지역 대학생의 성별, 식품영양전공 유무에 따른 영양지수와 영양지식의 비교 및 상관연구

변기원 한국식품영양학회 2017 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2017 No.12

Isoflavone의 생리적 기능에 관한 고찰

변기원 부천대학 2001 論文集 Vol.22 No.-

본 논문은 최근에 호르몬 관련 만성질환의 대체제로 각광받고 있는 isoflavone의 체내이용률과 생리적 작용 및 작용기전에 대해 최근 진행된 연구를 토대로 고찰하였다. Isoflavone은 대두가 주된 급원으로, 비당질부분민 daidzein과 genistein이 생리활성을 띠는 물질이며, phytoestrogen이라고 한다. 그 구조가 estrogen, estradiol과 비슷하여 estrogen 수용체ß에 결합하므로, 체내에서 estrogen과 같은 작용은 하거나 antiestrogen작용을 할 수 있어서, 체내에서 호르몬 관련 질환, 즉, 유방암, 전립선암, 골다공증 등의 호르몬 요법의 대체제로 사용된다. Isoflavone의 생체이용률은 aglycone(비당질부분)의 형태, genistein보다는 daidzein의 형태, 액상식품의 형태일수록 높으며, 섭취간격이 짧을수록 장시간 일정수준을 유지할 수 있고, 장내세균, 섬유소의 존재가 그 영향을 미친다. Isoflavone은 효소 tyrosine kinase의 활성억제 및 항산화 효력에 의해 호르몬 관련질환의 예방 및 치료효과를 나타내는 것으로 집약된다.: Isoflavone은 담즙배설 촉진을 통해 혈중 cholesterol을 낮출 뿐 아니라, estrogen 활성, 혈관탄력성증가, 아테롬형성저해(효소활성저해로)등을 통해 심장병 예방에 관여하며, 신혈관내피세포 생성 저해(tyrosine kinase 저해) 및 항산화효력으로 암 예방에 관여하고, 파골세포의 활성을 억제하여 골보유량을 유지시킴으로써 골다공증 예방에 관여하는 것으로 보여진다. This review focuses on the physiological function and bioavailability of isoflavones. Isoflavones, highly present in soy protein, are phytoestrogens which act like a hormone, estrogen by binding to estrogen recepter β(ERβ) due to the similarity in structure. Estrogenic activity of isoflavones provides an alternative to the traditional hormone replacement therapy(HRT) for preventing hormone dependent conditions including cancers, cardiovascular disease, osteoporosis and menopausal symptoms. Bioavailability is influenced by the type of isoflavone, aglycone species, matrix state of food, interval of isoflavone intake, gut microflora, fiber, etc. The representative isoflavones are daidzein and genistein. Genistein, more effective than daidzein, is likely to provide a beneficial effect on the hormone dependent diseases by regulating the activity of protein tyrosine kinase as a highly specific inhibitor, and by inhibiting the production of reactive oxygen species as an antioxidant.