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배은희,이종운,마성권,김수완 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites and positive sodium balance. The plasma and urinary ANP (atrial natriuretic peptide) immunoreactivities were increased. ANP mRNA expression was increased in the heart and kidney, whereas that of NPR (natriuretic peptide receptor)-A and NPR-C mRNA was decreased in the kidney. The expression of NEP was decreased in the kidney. At day 14, urinary excretion of sodium did not differ from the control. The plasma ANP level and heart ANP mRNA expression returned to their control values. The expression of ANP mRNA in the kidney was increased in association with increased urinary ANP immunoreactivities. The expression of NPR-A in the kidney became normal, whereas that of NPR-C kept decreased. The expression of NEP (neutral endopeptidase) remained decreased. These findings suggest that the increased renal ANP synthesis in association with decreased metabolism via NEP and NPR-C may play a compensatory role against the development of sodium retention in nephrotic syndrome. The decreased of NPR-A expression in the kidney may contribute to the ANP resistance at day 7. The subsequent recovery of NPR-A expression may play a role in promoting sodium excretion in later stage (at day 14).
32년째 '인쇄' 외길 걸어 온 평화당인쇄(주) 조효준 실장
배은희,Bae, Eun-Hui 대한출판문화협회 1995 출판저널 Vol.174 No.-
조효준 실장은 인쇄기계들을 모두 분해 재조립할 수 있는 능력을 갖춘 '기계박사'로 정평나 있다. 아들이 어떻게 자라는지조차 제대로 신경쓰지 못할 만큼 고단했던 인쇄일을 32년째 계속하고 있는 조실장은 이제 후배 양성을 위한 기술 전수에 힘을 쏟고 있다. 아예 인쇄기 밑을 '무덤'으로 정할 만큼 조실장의 '인쇄' 외길의 신념은 확고하다.
제본 기술의 최고봉 '종이 재단사'로 20년째 일하고 있는 최성식씨
배은희,Bae, Eun-Hui 대한출판문화협회 1995 출판저널 Vol.176 No.-
제본소에서 일하기 시작한 지 25년이 되는 최성식씨는 제본 기술의 최고봉이라는 '종이재단'의 마술사다. 보기에 어려울 것 없는 종이재단도 섬세한 테크닉이 필요하다. 단면이 고르게 들어가야 책 규격에 꼭 맞고 책 모서리가 매끈한 '잘 생긴' 책이 나올 수 있다.
Pleural Effusion in a Peritoneal Dialysis Patient
배은희,김창성,Joon Seok Choi,김수완 전남대학교 의과학연구소 2011 전남의대학술지 Vol.47 No.1
A 34-year-old female presented with end-stage renal disease (ESRD) treated by peritoneal dialysis (CAPD) complained of a dry cough. Chest X-ray and chest computed tomography (CT) scan revealed massive right hydrothorax. Because the glucose concentration of pleural fluid was markedly high compared with that of serum, we performed isotope and contrast peritoneography. We used CT for localizing it. MRI was also trying to show transdiaphragmatic leakage in peritoneoflural fistula. Temporary discontinuation of CAPD, tetracycline instillation into the pleural space and surgical patch grafting of the diaphragmatic leak have all been described. A novel method may be videoassisted talc pleurodesis.
Gross Hematuria Associated with Genitourinary Tuberculosis
배은희,허숙희,김영희,황인상,최준석,김창성,마성권,김수완 전남대학교 의과학연구소 2013 전남의대학술지 Vol.49 No.1
A 27-year-old man presented to the emergency department with sudden onset of massive gross hematuria and urinary retention. Contrast-enhanced computed tomography imaging showed uneven, dilated calices and a narrowing of the renal pelvis in the left kidney; in addition, a large hematoma was noted in the urinary bladder. An emergency cystoscopy was performed following detection of the hematoma and blood clots were removed. A lesional biopsy, a tuberculosis (TB) culture, and urine cytology showed positive results for Mycobacterium tuberculosis. The clinical manifestations of genitourinary tuberculosis are nonspecific and are usually detected at a chronic stage. In conclusion,we report an unusual cause of acute kidney injury associated with a subacute stage of genitourinary tuberculosis that caused mucosal erosion and bleeding in the bladder.
배은희,김수완 대한약리학회 2006 The Korean Journal of Physiology & Pharmacology Vol.10 No.6
Alteration of Nitric Oxide Synthase and Guanylyl Cyclase Activity in Rats with Ischemia/Reperfusion Renal Injury
배은희,김수완 대한약리학회 2006 The Korean Journal of Physiology & Pharmacology Vol.10 No.6
The present study was designed to investigate the effects renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and local natriuretic peptide (NP) system for glomerulopathy induced in the experimental bilateral ureteral obstructive rats. Sprague-Dawley male rats (200~220 g body weight) were bilaterally obstructed by ligation of the proximal ureters for 24 hours. Control rats were treated in the same ways, except that no ligature was made. The glomeruli were isolated from cortex by graded sieve methods, and the mRNA expressions of local renin-angiotensin system (RAS), aldosterone synthase (CYP11B2), endothelin-1 (ET-1) and NP system were determined by real- time polymerase chain reaction. Following the bilateral ureteral obstruction, the mRNA expressions of renin, angiotensin converting enzyme 1 as well as ET-1 were increased, while that of angiotensin converting enzyme 2 was not changed. The expressions of CYP11B2 and angiotensin II receptors were not changed. C-type natriuretic peptide (CNP) expression was increased, while its receptors (natriuretic peptide receptor-B) were not changed. We suggest that the upregulation of local RAS and ET play a role in the progressive glomerular injury, and that the enhanced CNP activity also plays a compensatory role in obstructive uropathy in the glomerulus.