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경력단절 경험이 있는 여성근로자의 고용관계특성이 직무만족에 미치는 영향에 관한 연구 - 한국의 사례를 중심으로
배은진,김완민,조예희,문주상 동북아시아문화학회 2019 동북아 문화연구 Vol.1 No.61
The purpose of this study was to analyze the effects of employment stability, compensation fairness, participation opportunities, and peer relationships on job satisfaction, which are factors of employment relationship characteristics, among others, for workers with experience in career interruption discussed as a special environment of Korean society, and to obtain effective results from Korea's career interrupted woman employment creation policy. An analysis of 261 samples nationwide confirmed that employment stability, compensation fairness and peer relationships among the factors of employment relationship characteristics have a positive effect on job satisfaction for workers with experience in career interruption. This can be thought that a worker with experience in career interruption is often forced to endure the pain of re-use and to work hard, so that the stability of employment is taken more seriously, and that the anxiety that compensation will not be achieved equally because of the career break period is placing a greater psychological burden on her. Particularly well integrated into the personal and intimate with my colleagues in her career can see that the most important idea. At a time when policies on female workers are pouring in, employment policies of job seekers and general job seekers with career breaks should be differentiated. Korea is pushing for various measures to use women's human resources, but the situation has not improved much with much experience in career interruption. More in-depth analysis and active implementation of relevant alternative policies will be required.
배은진,이태원,박동준 대한의사협회 2020 대한의사협회지 Vol.63 No.1
Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and tends to increase among certain patients and/or with complex clinical conditions. Unfortunately, apart from conservative management, including drug withdrawal, no effective treatment is known for this condition. Therefore, in order to reduce the frequency of drug-induced nephrotoxicity, early recognition of renal toxicity and appropriate prevention strategies, such as understanding the exact mechanisms of renal injury, patient and drug-related risk factors, and preemptive measures are needed. In this review, we will present the mechanisms of drug-induced nephrotoxicity and general preventive strategies for clinical physicians.
빛간섭단층촬영기로 측정한 국소지점별 망막두께 정상치를 활용한 녹내장성 시야감도저하 진단능력
배은진,김경래,유영철,Eun Jin Bae,Kyoung Lae Kim,Young Cheol Yoo 대한안과학회 2014 대한안과학회지 Vol.55 No.6
Purpose: Recently, the introduction of spectral-domain optical coherence tomography (SD-OCT) has enabled measurement of retinal thickness in the posterior pole in 64 sectors. SD-OCT was used to evaluate the diagnostic effectiveness in detecting glaucomatous abnormality of visual field sensitivity. A normal value for retinal thickness was determined and then compared in corresponding local sectors. Methods: Thirty healthy controls and 30 glaucoma subjects were evaluated. Macular thickness values from the 4 adjacent square cells in an 8 x 8 posterior pole retinal thickness map were averaged for a mean retinal thickness (MRT) value. A normative database was prepared using the data from the healthy eyes of this study to determine the diagnostic criteria for MRT. If the MRT value was <5% (Criteria A) or <1% (Criteria B) of the normative database, it was considered to be abnormal. The abnormalities of the MRT value for each diagnostic criteria were compared with the visual field sensitivity results in the corresponding positions. Results: The concordance of abnormalities between MRT and visual field sensitivity at 16 measured points was low in both criteria A (Kappa value; -0.418~0.429) and B (Kappa value; -0.363~0.444). Based on the results of the visual field at each focal point, the sensitivities and specificities of MRT values using the 2 criteria ranged from 0% to 100%. Conclusions: In this study, MRT values showed low correlation and diagnostic ability to detect decreased sensitivity of the visual field in corresponding points, when customized criteria derived from a normative database were applied. J Korean Ophthalmol Soc 2014;55(6):860-867
배은진,이철순,이혜진,김석중,이승재 한국뇌신경과학회 2014 Experimental Neurobiology Vol.23 No.4
Parkinson’s disease is a multifactorial disorder with several genes linked to the familial types of the disease. ATP13A2 is one of thosegenes and encode for a transmembrane protein localized in lysosomes and late endosomes. Previous studies suggested the roles ofthis protein in lysosomal functions and cellular ion homeostasis. Here, we set out to investigate the role of ATP13A2 in lysosomalfunction and in metabolism of α-synuclein, another PD-linked protein whose accumulation is implicated in the pathogenesis. Wegenerated non-sense mutations in both copies of ATP13A2 gene in SH-SY5Y human neuroblastoma cells. We examined lysosomalfunction of ATP13A2-/- cells by measuring the accumulation of lysosomal substrate proteins, such as p62 and polyubiquitinatedproteins, induction of acidic compartments, and degradation of ectopically introduced dextran. None of these measures werealtered by ATP13A2 deficiency. The steady-state levels of α-synuclein in cells or secretion of this protein were unaltered eitherin ATP13A2-/- compared to the normal cells. Therefore, the proposed roles of ATP13A2 in lysosomal functions may not begeneralized and may depend on the cellular context. The ATP13A2-/- cells generated in the current study may provide a usefulcontrol for studies on the roles of PD genes in lysosomal functions.