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pH/온도 자극 응답성 하이드로젤에 고정화된 페니실린 G 아실레이즈
박태관 中央大學校 食糧資源硏究所 1995 食糧資源硏究所 論文集 Vol.7 No.1
페니실린 G 아실레이즈를 pH나 온도에 민감한 자극 응답성 상전이 하이드로젤에 고정화 하였다. 95 몰 퍼센트의 N-isopropylacrylamide와 5 몰 %의 NN′-dimethylaminopropylmethacrylamide의 모노머 조성과 소량의 가교제를 포함한 양이온성 하이드로젤 미립구에 효소는 역서스펜션 중합에 의하여 물리적으로 고정화 하였다. 고정화 효소의 온도 의존성 및 pH 의존성과 같은 속도론적 성질은 고정화되지 않은 성질과 많이 달랐다. 이는 pH/온도 자극 응답성 하이드로젤 담체가 고정화 효소의 반응속도에 매우 큰 영향을 미친다는 것을 암시한다.
박태관,김택경 한국생체재료학회 2004 생체재료학회지 Vol.8 No.4
Electrospun nanofibers have been explored as biomedical devices such as scaffolds, artificial skins, drug delivery vehicles, prostheses and anti-adhesion membranes. Electrospinning is a straightforward and versatile method to fabricate polymer-based novel fibers with diameter in the range of from less than 10 nm to over 10 mm. The electrospun nanofibers have a structure with high suface area to volume ratio and small pore size. In the living system, almost all of cells and tissues are surrounded by nanofibrous structures. This unique ECM biomimicking structure of electrospun nanofibers will be very promising for biomedical devices.
특발성 맥락막신생혈관병증으로 오진된 시신경유두연접 망막모세혈관종 1예
박태관 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
PURPOSE : To report a case of Retinal capillary hemangioma initially misdiagnosed to idiopathic choroidal neovascularization CASE REPORTS : A 23-year-old female with a 6-month history of decreased vision in the left eye was referred to our hospital on June 17, 2003. A dilated fundus examination of the left eye was revealed a juxtapapillary subretinal lesion with adjacent exudative retinal detachment and retinal folds. A fluorescein angiogram demonstrated early hyperfluorescence and late leakage of the dye. Based on these results, a diagnosis of Idiopathic choroidal neovascularization was made. No treatment was performed. But, a new lesion of capillary hemangioma was found in the fundus examination on April 9,2004. Therefore, we confirmed the juxtapapillary subretinal lesion to a juxtapapillary capillary hemangioma. Medical investigations revealed no systemic involvement. Treatment with laser photocoagulation to the peripheral capillary hemangioma was performed. CONCLUSION : Juxtapapillary capillary hemangioma usually growths exophytically, and an endophytic form of juxtapapillry capillary hemnagioma has not been reported in Korea. However, the endophytic juxtapapillary capillary hemangioma as this case can be misdiagnosed to a choroidal neovascularization.