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Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug
박천권,최영빈,김명훈,박민,이지은,이승호,박정환,윤경환 한국고분자학회 2011 Macromolecular Research Vol.19 No.11
In this study, we developed an esophageal stent capable of sustained delivery of an anticancer drug, fluorouracil (5-FU). The stents were coated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanofibers (DPN)via the electrospinning method, which exhibited a sustained drug release for up to 6 days. To prolong drug release,we also added the nanofiber layers composed of PLGA alone (PN), surrounding the DPN layer, as a more resistive diffusion barrier, where a period of drug release could be extended to 21 days with the DPN layer topped with another 192 μm thick PN layer. Therefore, we envisioned longer period of drug release with the thicker PN layers,obtained simply with a longer collection time of PLGA nanofibers via electrospinning. Overall, we concluded that the drug-delivery esophageal stent prepared in this study is promising in the long-term treatment of dysphagia caused by esophageal cancer.
Enhancing Cancer Immunotherapy using Biomaterials
박천권 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Unlike traditional approaches in oncology, cancer immunotherapy harnesses a patient’s coordinated and adaptive immune system in order to combat the disease. The benefits of cancer immunotherapy include the potential 1) to treat all types of cancer, regardless of the underlying mutations or cell of origin; 2) to prevent metastasis and relapse by generating memory antitumor immunity; and 3) to decrease side effects relative to conventional cytotoxic treatment. Still, the therapeutic index of cancer immunotherapy must be improved, since the proportion of patients responding to this approach remains unsatisfactory and the therapy often causes systemic toxicity following parental administration. To address these issues, we used various biomaterials-based drug delivery approaches to deliver immunomodulatory compounds in a spatiotemporally controlled manner in order to improve their efficacy and safety relative to conventional systemic administration.