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박장규,성범진,김영호,이증훈 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
206 medical students as being healthy and without a history of contact dermatitis were patch tested with the Hollister-stier standard batteries from February 1989 to March 1991. Men were 184(89.3%) and women were 22(10.7%). Of these, 15(7.3%) reacted to patch test allergens, among whom 8(53.3%) reacted with single substance and total number of sensitizer was 23. The most frequent sensitizers were : mercury chloride ammoniated 9 cases(4.4%), nickel sulfate 4 cases(1.9%), thimerosal 4 cases(1.9%), cinnamic alcohol 2 cases(1.0%), ethylenediamine. Balsam of Peru. benzyl alcohol and epoxy resin 1 case each(0.5%). Most reactors(65%) including all female reactors showed weak reaction(+1). These results gave two informations. One was that popular sensitizers were related with medicaments and metal, and the other was that data of contact sensitization in healthy control should precede those of contact dermatitis for correct evaluation of patch test data of contact dermatitis group.
박장규,성열훈,성범진 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
Numerous studies on epidemiological aspects of contact dermatitis due to various causative antigens have been reported n recent year in Korea. However, degree of sensitization in healthy persons was not reported till now in Korea. We have performed the patch test on patients with contact dermatitis and healthy persons. The study results were as follows; 1. Percent of positive reaction in patients with contact dermatitis was 45.9%. The common allergens of positive reactions were nickel sulfate(21.6%), potassium dichromate (10.8%), neomycin sulfate (8.1%), Balsam of Peru (8.1%), mercuric chloride, ammoniated (5.4%), p-phenylenediamine(5.4%), cinnamic alcohol(5.4%), ethylenediamine dihydrochloride (2.7%), formaldehyde(2.7%), wool wax alcohol(2.7%), thimerosal (2.7%), mercaptobenzothiazole(2.7%), imidazolidinyl urea(2.7%) in order of frequency. 2. Percent of positive reaction in healthy persons was 10.3% and the common allergens were mercuric chloride, ammoniated(5.2%), nickel sulfate(3.1%), cinnamic alcohol(2.1%), ethylenediamine dihydrochloride(1.0%), formaldehyde(1.0%), epoxy resin(1.0%), in order of frequency. We conclude that allergens associated with metals and drugs seem to be the dominant causes of contact dermatitis and healthy persons.
박장규,성열훈,성범진,김영호,이증훈 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2
The authors evaluated response to PUVA therapy in 44 vitiligo petients who did'nt show the spontaneous re-pigmentation. In the responded group to PUVA therapy after systemic administration of 8-methoxy psoralen, average MPD of female patients was 3.4 times higher than males, interestingly. Number of irradiation of UVA was similar between male and female, but total doses of female patients group were about 2 times than males till the first re-pigmented spots were noted. The response to PUVA therapy was quite different according to duration of disease and site of lesion. Therefore, we suppose that it is necessary to consider sex of patient, duration of disease, location of vitiligo before making a plan of PUVA therapy.