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Majarine의 중추신경계에 대한 작용(II) -마우스에 있어서 Majarine의 체온감소에 미치는 dopamine, serotonin 길항제의 작용에 관한 연구-
박영현,이종화,김유재,조병헌,Park, Young-Hyun,Lee, Jong-Hwoa,Kim, Yu-Jae,Cho, Byung-Heon The Korean Society of Pharmacology 1985 대한약리학잡지 Vol.21 No.2
Majarine that was isolated from Berberis Koreasra Palibin (Berberidaceae) is the isoquinoline alkaloid. The effects of dopaminergic and serotonergic antagonists on majarine induced changes in body temperature were studied in the mouse. Intraperitoneal administration of majarine produced dose-dependent hypothermia. At a dose of 0.1 mg/kg, majarine caused a slight increase in body temperature. Majarine-induced hyperthermia was attenuated by the 5-HT antagonist, cyproheptadine However, it caused hyothermia in mice pretreated with the DA antagonist, haloperidol, and hyperthermia in mice pretreated with haloperidol and cyproheptadine in comparision with haloperidol pretreatment. At a dose of 2.0 mg/kg, majarine-induced hypothermia was attenuated by haloperidol and cyproheptadine, respectively. In reserpine pretreated mice, majarine produced dose-dependent hypothermia. At a dose of 0.1 mg/kg, majarine pretreated with haloperidol caused no significant effect in body temperature. At a dose of 2.0 mg/kg, majarine-induced hypothermia was attenuated by haloperidol pretreatment in mice treated with reserpine and ${\alpha}$-methyl-p-tyrosine. These data suppose that both dopaminergic and serotonergic mechanisms in the brain mediate the effects of majarine on body temperature. We propose that majarine directly stimulate DA receptor, which secondarilly activate 5-HT neurons to cause changes in body temperature. 한국특산 매자나무(Berberis Koreana Palibin)의 뿌리에서 분리한 majarine은 isoquinoline 알카로이드로서 본 교실에서는 중추신경계에 대한 약리작용을 검토하고 있다. Majarine을 마우스 복강내로 투여하여 직장온도 변화와 haloperidol, cyproheptadine과 reserpine 등에 대한 약물 상호작용을 관찰하여 다음과 같은 성적을 얻었다. Majarine은 마우스에 있어서 용량의존적으로 현저한 체온감소를 나타내었으나, 0.1 mg/kg투여시 체온증가의 유의성을 보였다. 체온감소는 haloperidol과 cyproheptadine으로 억제되었다. Reserpine처치 마우스에 있어서 ${\alpha}$-methyl-p-tyrosine으로 전처치한 다음 majarine 2.0mg/kg 투여시 체온감소를 나타내었다. 이러한 결과로 보아 majarine의 체온변화는 dopamine과 serotonin수용체에 관련성이 있다고 사려되고, 체온감소는 dopamine수용체에 직접적으로 작용한다고 생각되는 바이다.
박영현,김용남,김수현,오석,최지호,김태열,Park, Young-Hyun,Kim, Yong-Nam,Kim, Su-Hyon,Oh, Seok,Choi, Ji-Ho,Kim, Tae-Youl The Korean Society of Physical Therapy 2010 대한물리치료학회지 Vol.22 No.4
Purpose: The purpose of this study was to measure changes in the H-reflex and V wave under loading conditions (e.g. prone and standing position) and to investigate whether postural change would affect the H-reflex and V wave in post stroke hemiplegic patients. Methods: Thirty persons with hemiplegia resulting from stroke (20 males, 10 females) participated in this study. Electromyography (EMG) was used to electrically stimulate and record the soleus H-reflexes and V waves under various loading conditions. The normality of the distribution of each variable (H latency, $H_{max}/M_{max}$ ratio, $V_{max}/M_{max}$ ratio) was tested using the Kolmogorov-Smirnov test. The means of normally distributed continuous data were assessed by independent t-test (${\alpha}$=0.05). Results: There were statistically significant differences in $H_{max}/M_{max}$ ratio (p<0.01), $V_{max}/M_{max}$ ratio (p<0.01), H latency (p<0.01) among the prone and standing position. Conclusion: We found that the H-reflex and V wave in standing position was more active to weight bearing load than prone position.
박영현,김영석,조병헌,Park, Y.H.,Kim, Y.S.,Cho, B.H. 대한약리학회 1983 대한약리학잡지 Vol.19 No.2
Buxus leaves(Buxus microphylla var. koreana Nakai) have been used as a folk medicine in treating woman's disease. The chemical constituents, which have teen identified from Buxus sempervirens L. in Europe, are so far known in isolation of buxus alkaloids, cyclobuxine, buxamine, norbuxamine and buxaminol. But But any study on the pharmacological action of Buxus microphylla var. koreana Nakai has not yet teen rallied out, however, active substances have not been identified. As an attempt to isolate the biologically active substances from this plant, the examination of chemical constituents was undertaken. In the experiment, the crystalline component$(C_{10}H_8O_4)$ obtained from Buxus microphylla var. koreana Nakai was identified as a 6-methoxy, 7-hydroxy coumarin by chemical and physical methods. We named this crystal buxuletin. Therefore, we intended to screen the pharmacological action of buxuletin, especially, its diuretic effects in rabbits. Buxuletin was intraveneously injected to the rabbit in the dose of 20 mg/kg, 10 mg/kg and 5 mg/kg. The variations of urine volume and minerals $(Na^+,\;K^+\;and\;Cl^-)$ in urine were measured at an interval of 15 minutes for 4 hours after the treatment of buxuletin. The observed results are as follows: 1) With the administration of buxuletin (20 mg/kg, 10 mg/kg), the remarkable increment of the excreted urine volume was observed during the relatively long period. Excretion rates of urinary minerals $(Na^+,\;K^+\;and\;Cl^-)$ were also increased. 2) In a dose of 5 mg/kg, the slight increment on the diuretic actions of rabbits was observed. From the above results, authors name this crystal buxuletin and buxuletin shows the diuretic action.
박영현,Park, Yeong-Hyeon 한국정보통신집흥협회 1997 정보화사회 Vol.115 No.-
2000년 문제해결을 위한 접근방법으로는 우선 고객이나 모든 경영자들, 실무자들이 문제를 인식하고 비즈니스 측면, 시스템 측면, 어플리케이션 측면에서 영향평가를 한 뒤에 그 결과에 맞게 규모나 비용, 범위를 산정하여 계획을 수립하고 대응전략의 선정 및 전략계획을 수립하고 이에 패키지 시스템의 업그레이드를 통한 설치 및 조정작업과 수정작업, 그리고 재개발 등의 상세분석 및 이행작업이 이루어져야 한다.
초고층건물에서의 소형풍력발전시스템 적용방안에 관한 연구
박영현(Young Hyun Park),장호진(Ho Jin Jang),박정하(Jung Ha Park),박성조(Sung Jo Park),박진철(Jin Chul Park) 대한설비공학회 2012 대한설비공학회 학술발표대회논문집 Vol.2012 No.11
Since due to the nature of high-rise buildings, the increase of wind speed according to the height of a building makes it possible to use high wind power resources, many countries led by some advanced nations are recently making steady and persistently effort in introducing small wind turbine systems as a step to lower electric power load in high-rise buildings. The aim of this research is to propose an optimum application process of a small wind turbine system in high-rise buildings. To achieve this goal, the case study on the applications of high-rise and tall buildings was conducted and selected the best application among them. With considerations based on the results, an application process which is verified by actually selecting a high-rise building was proposed.
박영현(Young Hyun Park),박정하(Jung Ha Park),박진철(Jin Chul Park),이언구(Eon Ku Rhee) 대한설비공학회 2013 설비공학 논문집 Vol.25 No.4
Thanks to the characteristic of high-rise buildings, the increase of wind speed according to the height of a building makes it possible to use high wind power resources, many countries led by some advanced nations are recently making steady and persistent effort in introducing small wind turbine systems as a step to lower electric power load in high-rise buildings. The aim of this research is to propose an optimum application process of a small wind turbine system in high-rise buildings. To achieve this goal, the case studies on the applications of high-rise and tall buildings were conducted and the best application among them was selected. On the basis of the case studies, an application process was proposed.