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사염화탄소 처리한 SD(rat)에 대한 진균발효쌍화탕의 간독성 치료효과 연구
이재훈(Lee Jaehoon),마충제(Ma Choongje),하혜경(Ha Hyekyung),전원경(Jeon Wonkyung),박화용(Park Hwayong),마진열(Ma Jinyeul) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
In this research, as a method for verifying the efficacy of Ssangwhatang and fungus-fermentated Ssangwhatang, a comparative study on the liver protection effect was conducted using animal experiments by inducing the liver toxicity with the CG₁₄ treatment. Inducing the liver damage resulted in the increase in the serum AST and ALP activity, and one day administration of the test material(CCl₄: 0.5 ㎖/㎏/day) caused 520 IU/L of the ASP activity leading to 29% enhancement in comparison with the normal group and 93% and 81% reductions in the fungus-fermentated Ssangwhatang-administered groups, BFST1 and BFST2, respectively. ALT is 42 IU/L for the normal group and 99 IU/L for the negative control group leading to 135% enhancement. 15 ㎖/㎏/day and 30 ㎖/㎏/day administrations of fungus-fermented Ssangwhatang(BFST) resulted in 51% and 45% decreases in the ALT concentration, respectively. One day administration of 30 ㎖/㎏ Ssangwhatang and fungus-fermentated Ssangwhatang caused the LDH in the plasma to tend to decrease. CCl₄(1.0 ㎖/㎏/day) administered at the 0th and 4th days led to the observation of the tendency toward the decrease in AST, ALT, and LDH contents. The results indicate that the function of Ssangwhatang is partly reinforced under the fungus-fermentated Ssangwhatang performed in order to verify the efficacy of Ssangwhatang's effect on the recovery from fatigues.
이지혜(Jihye Lee),이재훈(Jaehoon Lee),마충제(Choongje Ma),마진열(Jinyeul Ma) 한국한의학연구원 2009 한국한의학연구원논문집 Vol.15 No.1
In this study, we investigated the single dose toxicity and safety about water-extracted Galgeuntang. To evaluate single dose toxicity, 20 male and 20 female ICR mice were observed survival rates, general toxicity, changes of body weight for 14 days after single oral administration of 0 (control group), 1250, 2500 and 5000 ㎎/㎏ Galgeuntang. And after 14 day, We observed autopsy. Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 ㎎/㎏). LD50 of Galgeuntang might be over 5000 ㎎/㎏ and it is very safe to ICR mice.