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술류에 관한 연구(Ⅱ) : 한국산 창술과 백술의 사염화탄소 간독성에 대한 보간효과 비교
장일무(Il-Moo Chang),마응천(Woong-Chon Mar),김제훈(Jae Hoon Kim),염정록(Jeong Rok Youm),Michio TakidoMichio Takido 한국생약학회 1989 생약학회지 Vol.20 No.2
Traditional herbal drugs of Korea, namely, Atractylodes Rhizome(蒼朮) and Atractylodes Rhizome White(白朮) which are derived from an old-grown rhizome and a newly-grown rhizome of Atractylodes japonica Koidz. (Compositae), respectively, were investigated their potential liver-protective activities against hepatoto xicity induced by CCl₄ intoxication in mice. Each herbal drug was extracted separately with chloroform, methanol and butanol. No extract of Atractylodes Rhizome showed a singnificant reduction of the duration of hypnosis produced by hexobarbital after CCl₄ intoxication in mice. In addition, the the treatments of Atractlyodes Rhizome extracts produced no decrease of aspartate aminotransferase(EC 2.6.1.1) activity in serum. However, the methanol extract of Atractylodes Rhizome White exhibited a marked protection from hepatotoxicity induced by CCl₄ intoxication in mice. It produced significant reductions of the duration of hypnosis and serum enzyme activity, but no other exract showed liver-protectivie activity against CCl₄-induced hepatotoxicity.
사향함유 우황청심원액과 영묘향함유 우황청심원액의 혈압강하 작용 및 적출심장에 미치는 효과에 대한 약리효능 비교
최은욱,조명행,신상덕,마응천,Choi, Eun-Wook,Cho, Myung-Haing,Shin, Sang-Duk,Mar, Woong-Chon 한국생약학회 2000 생약학회지 Vol.31 No.3
WooHwangChungSimWon is a traditional prescription formula for treating with hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new prescription of WooHwangChungSimWon, the civet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law (CITES) on the commercial use of musk. We have made a comparative study of the effects on the hypertension and contractile force of heart between the musk-containing and civet-containing WooHwangChungSimWon. The SHR rats were used for investigating the effects on the hypertension and the rabbits were used for investigating effects on the contractile force of isolated heart. The blood pressure which was recorded during the adminstration period showed that all the samples except the low dose of musk-containing WooHwangChungSimWon decreased the blood pressure, and the effects on the heart works of all the samples were higher than control group, which resulted from the examination of isolated heart. These results suggest that all the musk-containing and civet-containing WooHwangChungSimWon formula have similar protective effects on hypertension and palpitation.
Mongolian Gerbil 의 뇌허혈 유발에 따른 뇌조직 손상에 있어서 사향 함유 우황청심원액과 영묘향 함유 우황청심원액의 조직학적 효능 비교
최은욱(Eun Wook Choi),이장헌(Jang Heon Lee),신상덕(Sang Duk Shin),마응천(Woong Chon Mar) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.3
WooHwangChungSimWon is a traditional prescription for treating with hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new presciption of WooHwangChungSimWon, the civet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law about the musk. We have made a comparative study of the effects on the ischemic damage between the musk containing and civet containing WooHwangChungSimWon. In order to investigate the effects of WooHwangChungSimWon on the ischemic damage, each samples were adminstrated for 12 days, ischemia was induced for 10 minutes at 7th day, and immunohistochemistry was performed in the region of hippocampus of mongolian gerbils. According to the result of immunohistochemistry, the survival rates of neuroal cells in the hippocampal CA1 region are 37.8% in the high dose of musk containing WooHwangChungSimWon (HM-WHCSW) administrated group, 27.8% in low dose of civet containing WooHwangChungSimWon (LC-WHCSW), and 35.5% in high dose of civet containg WooHwangChungSimWon (HC-WHCSW) administrated group. These survial rates were significantly different from the survival rate of sham control group (14.4%). The results suggest that all the samples except the low dose of musk containing WooHwangChungSimWon (LM-WHCSW) have protective or preventive effects on cerebral ischemia.