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폐경여성에서 수술과 호르몬대치요법에 따른 골밀도의 변화
정혁,김영호,류경철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11
The objective of this study is to compare bone mineral densities(BMD) between the symp-tomatic menopausal women and the asymptomatic menopausal women, between the spontaneous menopausal group and the surgical menopausal group, and especially between the HRT group and no-HRT group. From January, 1995 to December 1995, this study was prospectively analysed in 96 menopausal women(47 spontaneous menopausal women, 23 surgical nopausal women) who were admitted to Department of Obstetrics and Gynecology, Chosun University Hospital for HRT. The all women was measured T-score of bone mineral densities at L1, L2, L3 and L4 of lumbar spine and neck, trochanter, ward`s area of femur from dual-energy X-ray absorptiometry(DEXA). Student t-test and chi-squre test were used for statistical comparison. The results obtained were as follows: 1. The mean age of the osteoporotic group(54.96±6.6) is higher than the non-osteoporotic group(50.55±81). 2. No difference is detected in the BMD between the surgical menopausal group and the spontaneous menopausal group, because duration of the follow-up is too short and the study group is too small perhaps. 3. Descent of T-score in the symtomatic menopausal women is not severe than the asymptomatic group, but especially in L4 area, T-score of the symptomatic group(-1.76±1.3<-1.04 ±1.4) is more decreased(p<0.04). 4. T-score between the long term HRT group and the no-HRT group is different markedly. HRT during only 1 year is not attributed to BMD loss. So the continuous HRT over 1 year and Follow-up is need to improvement of BMD in the menopausal women with risk factors.
난소의 양성기형종에서 발생한 소세포암의 좌측 견갑상부임파선 원격전이 1 례
한세준,최상준,류경철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.2
The development of cancer in a pre-existing benign cystic teratoma of the ovary with distant metastasis to the supraclavicular lymph nodes has not been previously reported. We experienced a case of a 28-year-old woman with distant metastasis from small cell cacinoma arising in benign mature cystic teratoma of the ovary to the supraclavicular lymph nodes. The staging laparotomy and total abdominal hysterectomy with both salpingooophorectomy were peformed. There was no metastatic site except the supraclavicular lymph nodes, thereafter adjuvant chemotherapies with bleomycin, etoposide, cisplatin have been doing. We report a case of benign cystic teratoma with malignant change and metastasis with the literature.
정혁,한세준,최상준,송창훈,임성철,김영호,류경철,여인동 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.4
저자 등은 경우 난소의 악성 중배엽성 혼재성 종양을 경험하였으며, 환자는 수술 후 병기 Ⅲc로 한차례 복합 화학요법 시행 후 6 개월째 생존중이다. Malignant mixed m llerian tumor (MMMT) of the ovary is a rare tumor with dismal prognosis. MMMT by definition contain epithelial and mensenchymal elements, both of which are histologically malignant. They are classified as endometrial lesions because the glands often appear endometrial-like and the stroma resemble that of the endometrium. The disease is usually advanced (Stage Ⅲ) when diagnosed and thus provides a difficult challenge to any postoperative therapy. We experienced a case of MMMT of ovary with neuroectodermal differentiation in 69 years-old multiparous women and report our experience with a brief review of literature.
상피성 난소암에서 면역화학적 염색에 의한 bc1-2와 p53 유전자발현에 관한 연구
정혁,한세준,최상준,송창훈,임성철,김영호,류경철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11
Bcl-2 and p53, two proteins, have implicated in apoptosis and among them p53 is known as adverse prognostic factor in a number of tumors. But it is variable in different tissues whe-ther bcl-2 expression and its role are related in the prognosis. The present study was aimed to find the role of bcl-2 and p53 in prognosis of epithelial ovarian cancer. We examined 32 epithelial ovarian cancer specimens of different histologic types and stages by immunohistochemical staining. Bcl-2 protein expression was found in 11/32 epithelial ovarian cancers and it was related in survival(p=0.0038) and p53 accumulation was found in 17/32 epithelial ovarian cancers but it was not rrelated in survival(p=0.0717). But bcl-2 expression and p53 accumulation were not related to the FIGO stages(p>0.05). The analysis of the postoperative course of 32 patients showed that survival depended on the FIGO stages(p=0.001 2) and the histologic type(p=0.009). However, bcl-2 immunohistochemistry identified a subgroup of patients with p53 and bcl-2 positive carcinomas who had not a statistically better outcome(p=0.082) than patients with p53 positive and bcl-2 negative carcinomas. Thus our observations point to different molecular alterations possibly underlying phenotypic diversity of ovarian carcinomas and provide clues for a better understanding of tumor progression in these neoplasms.