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생약복합제의 약효연구 (제4보) : 황연해독탕의 중추신경계 작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),두호경(H. K. Doo),김남재(N. J. Kim) 한국생약학회 1982 생약학회지 Vol.13 No.1
In order to investigate the pharmacological action of combined preparation of crude drugs, Whangryonhaedok-Tang were studied. Pharmacological studies of the water extract, methanol insoluble fraction and methanol soluble fraction obtained from Whangryonhaedok-Tang were conducted. The results of this investigation were summarized as follows; Central convulsions induced by strychnine, picrotoxine and caffeine were depressed in mice. Analgesic effect was observed in mice and rats. Antipyretic effect was observed in rats and rabbits. Sedative effect was observed.
생약복합제의 약효연구 (제5보) : 황연해독탕이 부종, 장관, 혈압, 혈당량, 총코레스테롤 함량 및 항균작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),두호경(H. K. Doo),김남재(N. J. Kim) 한국생약학회 1982 생약학회지 Vol.13 No.1
In order to investigate the effect of Whangryonhaedok-Tang on the anti-inflammatory, ileum of mice, blood pressure, blood glucose, total cholesterol and antibacterial activity, those pharmacological actions were conducted. The results of this studies were summerized as follows; Rat hind paw edema induced by acetic acid was inhibited. In mice, tone of intestinal smooth muscle was suppressed with the treatment of sample and intestinal contractions induced by BaCl₂ was inhibited. Hypertensive effect was not observed in rabbits but was observed by the water extract of Whangryonhaedok-Tang excluded Phellodendri Cortex in rabbits. The incleased blood glucose levels in alloxandiabetic rabbits were significantly decreased by the oral administration of the sample I after 6 days. The total cholesterol levels in alloxan-induced rabbits were significantly decreased by the oral administration of the sample I after 9 days. Antibacterial activity was observed. In addition, we thought the pharmacological actions were significantly noted by the sample III(Methanol soluble fraction) because of the purification of effective components.