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노진기(Jin Ki Roh),김혜진(Hye Jin Kim),김갑일(Kab Il Kim) 대한전기학회 2014 전기학회논문지 Vol.63 No.9
Recently, as the wide spread of smart phone, pico projector which is used at the smart phone is appeared as a portable display device. In this paper, among several pico projectors, laser beam scanner module is dealt with in which laser is used as light source, and mems-mirror is used as optical panel. In this device, screen image quality is a special issue, and blur effect is a typical adverse effect to the quality of this device. So the enhancement of this blur effect has an important factor of the quality of the device. The definition of the blur and the main source of the blur are studied and the simulation results and way of improvement are also suggested.
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산화질소가 미생물에 미치는 영향 및 이를 이용한 항균전략
최은영,노진기,핫산눌하스니,유진욱,Choi, Eun Young,Noh, Jin-Ki,Hasan, Nurhasni,Yoo, Jin-Wook 한국미생물학회 2014 미생물학회지 Vol.50 No.2
인체의 항상성 유지에 필수적인 물질로 알려진 산화질소는 인체를 침입한 미생물로부터 보호하는 면역반응에서 매우 중요한 역할을 담당하고 있다. 산화질소는 미생물에 직간접적으로 작용하여 다양한 기전으로 항균작용을 나타낸다. 항생제의 심각한 내성이 심각한 사회적 문제로 대두되면서 새로운 계열의 항생제 개발이 절실한 시점에서 항균물질로서의 산화질소에 대한 연구가 활발히 진행되고 있다. 하지만 매우 짧은 반감기와 기체분자인 산화질소를 항생제로 이용하기 위해서는 산화질소의 저장과 방출을 제어할 전략 필요하다. 본 총설에서는 산화질소의 체내에서의 생화학적 특성과 항균작용을 나타내는 다양한 기전에 대해 설명하였다. 또한 산화질소 방출을 조절하여 항균작용을 향상시키는 최근의 연구에 대해 알아보았다. Nitric oxide (NO), which has been recognized as an integral molecule in maintaining homeostasis, plays an important role in host defense against microbes. NO has diverse antimicrobial mechanisms by directly and/or indirectly interacting with microbes. Under the circumstance that there is an urgent need for a new class of antimicrobial agents due to antibiotic resistance, much effort has been made to develop a NO-based antimicrobial agent. In order to make it possible, strategies to store and release NO in a controlled manner are required because NO has a gaseous property and a very short half-life. In this review, we described NO biochemistry and its mechanisms of antimicrobial activity. In additions, we introduced various NO-releasing systems that improve NO's antimicrobial activity.
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Hh-Ag1.5 처리가 돼지 체외수정란의 발육 및 세포사멸에 미치는 영향
권대진,여재훈,노원근,곽태욱,오건봉,옥선아,임석기,박진기,황성수 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.3
The present study was performed to investigate the effect of Hh-Ag1.5, a small-molecule chemical agonist of SMOothened receptor, on the in vitro maturation and development of in vitro fertilized (IVF) embryos in pigs. Oocytes or fertilized embryos were cultured in a maturation or embryo culture medium supplemented with 0 (control), 25, 50 or 100 nM of Hh-Ag1.5, respectively. Although the maturation rate were not different among treatment groups, the blastocyst formation rate in the group treated with 25 nM Hh-Ag1.5 was significantly increased compared to other groups (P<0.05). While the highest dose of Hh-Ag1.5 (100 nM) did negatively affect to the embryo development and cell number in blastocysts compared to other groups (P<0.05), the apoptotic cell index in blastocysts was significantly lower in 25 and 50 nM groups than in control and 100 nM groups (P<0.05). The mRNA expression of the proapoptotic gene Bax and the ratio of Bax/Bcl-XL decreased in among treatment groups compared to control (P<0.05). The embryo quality related genes, Tert and Zfp42, were significantly decreased in 50 and 100 nM groups compared with control and 25 nM groups (P<0.05). In conclusion, the addition of 25 nM Hh-Ag1.5 to in vitro maturation and culture medium can enhance the developmental potential as well as quality of IVF embryos in pig.
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2단 선회류 유동층 연소로내에서 저품위 무연탄의 연소특성(1)
이제근,신용섭,허철구,노진기,전해수 한국화학공학회 1988 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.26 No.5
연소효율을 증진시키기 위하여 2단 선회류 유동층 연소로를 고안하였다. 이 연소로는 하단과 상단의 두개 층으로 구성되었고 층내 물질이 연속 배출되는 일류관이 각 층에 설치되어 연속 조작되었다. 하단으로 부터 상승하는 연소기체(미분고체 입자를 포함한)는 2단 분산판에 부착된 4개 노즐을 통과하여 접선류를 이루고, 분산판 윗판의 다공을 통과하는 2차 공기는 축류를 이루도록 구성되었다. 이는 "축류-접선류 선회류- 장치"에 상당되며, 비산되는 미세입자가 원심력에 의해 기벽을 타고 하강해서 2단 분산판 위에 수집되어 2차 공기에 의해 유동화 되면서 동시에 연소된다. 이 장치에서 국내산 저품위 무연탄(총발열량=2,810㎉/㎏, 입자경<2mm)의 연소실험을 수행하였다. 실험결과 선회류 영향으로 인하여 비산유출량과 미연소 탄소 손실량이 같은 크기의 단단 유동층 연소로에 비하여 크게 감소하였고 연소효율은 단단 유동층 연소로에 비하여 약 20% 이상 증진되었다. A two-stage swirl-flow fluidized bed combustoc(FBC) has been devised to increase the combustion efficiency. The combustor consists of a first stage and a second stage with overflow drain, respectively. The combustion gas, including fine particles from the first stage, is tangentially introduced into the second stage through 4 nozzles, which are inserted into holes drilled in the second stage distributor, and secondary air is axially introduced through multiorifices drilled on the upper plate of the second distributor. The second stage is equivalent to a "axial-plus-tangential entry swirl generator", so that fine particles in the second stage are thrown to the wall under the influence of centrifugal forces in the swirl-flow,decended, collected on the second distributor, fluidized by the secondary air, and burnt within the second stage. Hot bed tests are carried out using low-grade anthracite (gross heating value=2,810㎉/㎏, particle diameter<2 ㎜). Due to the effect of swirl-flow, the amount of fines elutriated and the unburned carbon loss are considerably reduced in the two-stage swirl-flow FBC as compared with the same size single-stage FBC. Combustion efficiency is increased by about 20% as compared with the same size single stage FBC.
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Jiafu Cao,유진욱,Muhammad Naeem,노진기,이은희 한국고분자학회 2015 Macromolecular Research Vol.23 No.5
Activated macrophages play a central role in the pathology of inflammatory diseases by secreting proinflammatory cytokines. In this study, we have developed folate-conjugated dexamethasone phosphate (DP)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) that can selectively target to activated macrophages for alleviation of inflammatory responses. DP was loaded into PLGA nanoparticles in an amorphous form using an ionic interaction between DP, zinc, and PLGA. Folic acid (FA) was used as a targeting ligand for activated macrophages and conjugated onto DPNPs (FA-DPNPs). The mean particle size of DPNPs and FA-DPNPs was 126±36 and 133±28 nm, respectively. The zeta potential of DPNPs and FA-DPNPs were -13.5±0.4 mV and -14.9±0.9 mV, respectively. Sustained and controlled DP release over 48 hours from DPNPs and FA-DPNPs was observed. The low cellular uptake of both DPNPs and FA-DPNPs was observed in normal RAW264.7 macrophages, whereas significantly higher cellular uptake of FA-DPNPs was observed as compared to DPNPs in activated RAW264.7 macrophages. The production of pro-inflammatory cytokines (IL-6 and TNF-α) and nitric oxide (NO) from activated macrophages was inhibited more significantly by FA-DPNPs than by free DP and DPNPs. Taken together, DP-loaded nanoparticles, especially when conjugated with FA, were selectively internalized by activated macrophages and effectively suppressed inflammatory responses. DP loaded folate-conjugated PLGA nanoparticles presented in this study may offer a promising approach of targeted delivery to activated macrophages for the treatment of inflammatory diseases.
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