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노건웅,김동수,이기영 대한천식알레르기학회 1994 천식 및 알레르기 Vol.14 No.1
Kawasaki disease is an acute febrile illness affecting maily infants and children and characterized by systemic vasculitis with multiple immunologic abnormalities, Heat shock proteins have many functions such as inflammation and autoimmunity. To observe the role of heat shock protein in the Kawasaki disease, antibody responses to mycobacterial 65kDa protein were examined by ELISA and immunoblotting using acute and subacute phase sera of 10 patients with Kawasaki disease. Markedly increased antibody titer against antigen of BCG and perchloric acid extracted mycobacterial 65kDa protein were observed in the subacute sera compared to their acute sera, but not against purified protein derivatives(PPD) and lipoarabinomannan(LAM). By immunoblotting, the subacute sera reacted with 65 kDa protein strongly and other proteins of sonicated BCG antigen, and also reacted with 65 kDa protein of perchloric acid soluble BCG antigen, but the acute serum did not. These results indicated that BCG extracted mycobacterial heat shock protein 65 might have play some important roles in pathogenesis of Kawasaki disease 2 we suggest autoreactivity to host HSP65 similar to mucobacterial HSP65 and further study on the roles or functions of this mycobacterial heat shock protein 65 or the auto-reactivity to self HSP65 should be done.
노건웅(Geun Woong Noh),이우길(Woo Gill Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1997 소아알레르기 및 호흡기학회지 Vol.7 No.2
N/A Purpose: Atopic dermatitis is characterized by immunologic abnormalities including evidence for reduced IFN-γ production with increased IL-4 production. Previous open trials have suggested efficacy for recombinant IFN-γ in treatment of severe atopic dermatitis. Here we report the results of treatment with IFN-γ in 5 patients with moderate to severe atopic dermatitis. Methods: Atopic dermatitis was diagnosed according to typical clinical symptoms. Patients were treated with IFN- r for 6 weeks. Patients received 2×10(6) units/m IFN-γ by subcutaneous injection. Serum IgE levels, total eosinophil counts with hemoglobin(Hb) concentrations, hematocrit(Hct)s, white blood cell counts(WBC), lymphocyte fractions, eosinophil fractions and platelet counts were examined before treatment and 1 week and 6 week after treatment. Results: The skin lesions of all patients begun to be improved after 3 times of injection. As estimated by patients, responses showed significant improvement. Three of five patients were resolved completely who showed complete clearance of skin manifestation. And remained two patients show dramatic improvement with mild some skin lesions. WBC counts, Hemoglobins, Hematocrits, lymphocyte fractions, eosinophil fractions and platelet counts was not significantly changed before and after IFN-γ treatment. Serum IgE levels were not markedly elevated and not reduced after IFN-γ treatment. But total eosinophil counts were decreased 1 week after treatment and reduced to normal range 6 weeks after treatment. Conclusions: Five severe atopic dermatitis patients who did not respond to previous treatment, who had showed complication to loeal steroid treatment and who had severe skin lesions were treated with IFN-γ. They showed marked improvement in skin lesions after IFN-γ treatment and three of them showed complete clearance of skin lesions. Total eosinophil count was regarded as an excellent indicator for diagnosis, evaluation of therapeutic effects of IFN-γ. IFN-γ may be a suitable immunotherapy modality in the treatment of atopic dermatitis and futher studies for the action mechanism of IFN-γ in atopic dermatitis might be needed.