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Interleukin-17이 배양된 류마티스관절염 활막세포에서 vascular endothelial growth factor 생성에 미치는 영향
곽임수 ( Ihm Soo Kwak ),남태수 ( Tae Soo Nam ),나하연 ( Ha Yeon Rha ),서정탁 ( Jeung Tak Suh ),김유선 ( Yoo Sun Kim ),김성일 ( Sung Il Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3
Objective: To investigate the the effects of interleukin-17 (IL-17) on the production of vascular endothelial growth factor (VEGF) from cultured rheumatoid arthritis synoviocytes. Methods: Fibroblast-like synovial cells(FLS) were prepared from the synovial tissues of rheumatoid arthritis patients and cultured in the presence of IL-17, IL-17 with or without transforming growth factor-β(TGF-β), tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β). VEGF levels were determined in the culture supernatants by sandwitch ELISA. Results: Stimulation of FLS by serial concentration of IL-17, TGF-β, TNF-α, IL-1β increased the production of VEGF by 2.1-2.7, 2.2-3.0, 2.0-2.9, 2.3-3.1 fold over the constitutive levels of unstimulated FLS. Stimulation of FLS by IL-17 with TGF-β or TNF-α or IL-1β also increased the production of VEGF according to culture periods by 1.6-1.8, 1.1-1.9, 1.5-1.7 fold over the levels stimulated with TGF-β or TNF-α or IL-1β, respectively. This results indicated that IL-17 increased the effect of TGF-β, TNF-α, IL-1β on FLS, leading synergistic enhancement of VEGF production. Conclusion: IL-17 may be involved in the neovascularization in rheumatoid synovitis by enhancing the production of VEGF.
김상수 ( Sang Soo Kim ),이주호 ( Joo Ho Lee ),남태수 ( Tae Su Nam ),김성일 ( Sung Il Kim ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Polyarteritis nodosa is a necrotizing vasculitis affecting medium and small-sized arteries throughout the body. Eye involvement is present in about 10% to 20% of patients, including chemosis, iritis, episcleritis, corneal ulcers, keratitiis, choroiditis, retinal detachment, extraocular muscle palsies, and hypertensive retinopathy. Rarely there have been reports of optic neuropathies and occasional central retinal artery occlusions. We experienced a patient with central retinal artery occlusion who had been diagnosed polyarteritis nodosa with mononeuritis multiplex.
폐경 전 초기 류마티스 관절염 환자의 전신 골 소실 발생 빈도와 연관인자
김성일 ( Sung Il Kim ),남태수 ( Tae Soo Nam ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Objective: To investigate frequency and associated factors of generalized bone loss in patients with premeonpausal early rheumatoid arthritis (RA) who had not been treated with corticosteroid. Methods: We measured bone mineral density (BMD) of lumbar spine and hip by dual energy X-ray absorptiometry (DEXA, Hologic QDR 4500) and investigated clinical; age, disease duration, numbers of tender and swollen joint, and laboratory; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF), variables in patients with premenopausal early RA who had not been treated with corticosteroid, consecutively. Generalized bone loss was defined as T score less than -1, and clinical and laboratory variables were analyzed for generalized bone loss. Results: In 41 patients with premenopausal early RA (age; 38±8 years, duration of disease 8±6 months), the frequency of generalized bone loss in lumbar spine and hip were 35% and 46%. In multivariate logistic regression analysis, elevated CRP level was significantly associated with generalized bone loss in lumbar spine and femur neck. Conclusions: In patients with premenopausal early RA, elevated CRP level was associated with generalized bone loss of lumbar spine and femur neck.