http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
(하버마스와 드워킨으로) ‘나라다움’의 개념 만들기 - 한 나라에서 법체계 구성의 정당함과 작동의 온전함은 ‘나라다운 나라’에 대한 시민적 요청에 충분히 부응하는가?
남성일 한국문화융합학회 2022 문화와 융합 Vol.44 No.10
The purpose of this paper is to conceptualize sustainable development state model by building a ‘state-likeness’ concept. Habermas insists that a state’s legal system is problem of making a right political regime. For him, the state-like concept for sustainable state model comes from legal system’s design and institutionalization. By contrast, Dworkin’s legal system problem is a key whether political community’s function operates smoothly. As being a composition of legitimacy criteria and integrity criteria, the complementary co-attribute principle in a state standard model of state-likeness is inherent in two law philosopher’s concepts with conceiving as law philosophy. Korean ‘state-likeness’ criteria is safety, justice, liberty, happiness. In compliance with criteria, we must constitute and operate a legal system, judge and citizen together fulfill one’s responsibility.
와우 세포주에서 겐타마이신에 의해 유발된 세포자멸사의 특성
남성일,송대규,박성희,이재훈,이우근,김일만,박재식 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.3
Background and Objectives:Aminoglycoside antibiotics are ototoxic. Understanding of the molecular mechanisms underlying the drug-induced ototoxicity, however, has been hampered by limited cell availability. Recently, HEI-OC1 cells, which are of an immortalized cochlear cell line sensitive to ototoxic drugs, have been derived from the auditory sensory organ. This study was performed to confirm whether cultured HEI-OC1 cells can be used to evaluate aminoglycoside-induced ototoxicity and the effect of antioxidants against aminoglycoside-induced colchlear cell damage. Materials and Method:Gentamicin was administered for 3 days in the media containing HEI-OC1 cells. Results:Cell viability was decreased by gentamicin in a dose-dependent manner. The cell number was decreased by 50% 3 days after the exposure to 2 mM gentamicin. Penicillin did not have any significant effect. Flow cytometric analysis revealed that sub G1 arrest representing cellular apoptosis was accelerated by gentamicin treatment but not by penicillin. Expression of p27Kip1, the cyclin-dependent kinase inhibitor, was exclusively increased by gentamicin. Reactive oxygen species were also increased by gentamicin when compared with those of the control or when penicillin was used. Caspase-3 activity became increased according to the elevation of gentamicin concentrations. N-acetyl cysteine, but not vitamin E or vitamin C, ameliorated cell survival dose-dependently against gentamicin. Conclusion:The present study reveals that the HEI-OC1 cell line is a good model to evaluate gentamicin-induced ototoxicity. The results suggest that gentamicin-induced apoptosis may be, at least partially, linked to the overproduction of a reactive oxygen species called. Nacetyl cysteine, a free radical scavenger, that decreases the gentamicin ototoxicity.
남성일 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.8
Endolymphatic hydrops (EH) represents a histopathologic finding in which the structures bounding the endolymphatic space are distended by an enlargement of endolymphatic volume. EH primarily involves the cochlear duct and saccule but can involve the utricle and ampullae of the semicircular canals. EH is a consistent finding in patients with Meniere’s disease, however, the reverse is not true. EH may occur as a consequence of a variety of disorders, including DFNA 9, Alport syndrome, serous labyrinthitis, suppurative labyrinthitis, otosyphilis, temporal bone fracture, surgical trauma, neoplasm, immune disorders, otosclerosis, or Paget’s disease. The mechanism of development of hydrops is also unclear. This review provides information to understand the recent pathophysiologic mechanism and causal disoders in EH.