옻나무 칠액성분중 Urushiol 의 암세포증식억제 효과 - in vitro 세포독성효과 -

나천수,정남철,김훈택,조용백 한국산림과학회 1997 한국임학회 정기학술발표논문집 Vol.1997 No.-

옻나무 칠액성분 중 Urushiol 의 암세포 증식억제 효과 - in vitro 세포독성효과 -

나천수,정남철,오광인 ( Chun Soo Na,Nam Chul Jung,Kwang In Oh ) 한국산림과학회 1998 한국산림과학회지 Vol.87 No.2

This study was conducted to screen the biological activity of urushiol in the sap of lac tree(Rhus verniciflua STOKES) which has been used in traditional folk remedies. Cytotoxic activity of urushiol was screened with L1210(mouse luekemia cell), PC-9(human lung adenocarcinoma cell), A427(human lung adenocarcinoma cell) and KATO IlI(human stomach adenocarcinoma cell) The stepwise hexane : acetone eluent fractions of the urushiol were obtained by the silica gel adsorption column chromatography and added to the culture media containing L1210, PC-9. A427, and KATO III, respectively. A hexane : acetone(90 : 10, v/v) eluent fraction of them showed the lowest 50% inhibition concentration(IC_(50)) of 0.018㎍/㎖ for the cell line of A427. Much lower level of IC_(50) of the hexane : acetone(90 : 10, v/v) eluent fraction of the urushiol showed the equal inhibition effect with tetraplatin(i.e., anti-cancer drug of platinum complexes) on the cancer cell lines as follows ; 3.4 times lower for L1210, 3.9 times lower for PC-9, and 105.5 times lower for A427. However, IC_(50) of the hexane : acetone(90 : 10 v/v) eluent fraction for KATO III was exceptionally 3.9 times higher than that of tetraplatin.

나주지역 동학관련 구술자료 수집과 그 의의 - 나주시, 세계적 동학 명소를 위한 試論 -

나천수(羅千洙),이영기(李英紀) 원광대학교 원불교사상연구원 2020 원불교사상과 종교문화 Vol.86 No.-

2019년도「 나주시-원광대학교-일본측 동학 유적지 답사단」 3자가 나주시에서 나주 동학농민운동 연구에 뜻을 같이하고 장차 일본측이 위령탑을 건립키로 뜻을 모아 3자가 MOU를 체결한 바 있다. 문제는 1894년부터 현재까지 동학 관련 참여자 현황을 한번도 전수 조사한 적이 없다는 것이다. 현재까지 찾아낸 동학농민군이 겨우 3,670명이고, 채록된 증언도 겨우 97건에 불과하다. 과연 동학농민군 총 참여 인원을 알 수 있을까? 그중에 죽은 자는 몇 명인지, 후손이 누구인지 조사하지 않은 상황에서 비록 일본측에서 위령탑을 세운다 하여도 한(恨)이 흥(興)으로 승화될 수는 없다. 이 연구는 동학 구술 수집의 의의를 피력하고 구술 찾기 방안을 제시하고자 한다. 연구의 내용은 첫 번째, 기존 동학 관련 기록 문서를 바탕으로 동학참여자 전체를 추정해 보고, 두 번째, 이와 같은 동학 참여자가 일제강점기 동안 역사의 뒤안길에 숨을 수밖에 없는 이유를 들어 구술 찾기 방안을 제시하고자 한다. 세 번째, 2019년 제1회 나주 동학 한일 학술대회 때 슬로건을 ‘한에서 흥으로 승화하다’로 정한 바, 한을 흥으로 승화하는 방안을 제시하고자 한다. 구전 수집을 통해 동학농민군과 그들 후손들의 한의 소리를 아울러 채록할 수 있다면, 이것을 편석판(片石板)에 새겨 위령탑 주변에 비군(碑群)으로 배치하면 마침내 한이 흥으로 승화되지 않을까? 이 연구의 결과를 나주시가 행정적으로 실천할 경우 나주는 명소로 부각될 것이다. 나주에 가면 동학으로 죽은 자의 한의 소리, 살아남은 자의 한의 소리, 그들 후손들의 한의 소리를 들을 수 있기 때문이다. In 2019, the MOU was executed by three parties—Naju city, Wonkwang University, Japanese exploration group —who agreed to study Naju Donghak Peasant Movement and have the Japanese group to build a memorial tower in the future. The status of participants for Donghak Peasant Movement has never been completely investigated until now. Only 3,670 names of Donghak Peasant Army have been found so far and only 97 testimonies have been recorded. Even if the memorial tower is set up by Japanese, the peasant army’s resentment cannot be sublimated into excitement without investigating the total number of participants, the number of deaths and who their descendants are. The study seeks to express the significance of collecting verbal evidences as well as the voices of deep sorrow of Donghak Peasant Army and suggest solutions to find them. The content of this study is to estimate the entire Donghak participants based on the existing Donghak-related documents and suggest solutions to find verbal evidences about the them who were forced to hide in the back of history during Japanese colonial era. Lastly, the study would propose plans to sublimate the resentment into excitement as stated in the slogan—“Sublimate the resentment into excitement”—from the first Korea-Japan academic conference for Donghak which took place in Naju in 2019. Once the collected verbal evidences of Donghak Peasant Army are engraved on the piece of stone plate and placed around the memorial tower, their resentment will finally be sublimated into joy. Naju City would become a landmark for Donghak if its administration put the plans into practice. People will be able to feel the resentment of Donghak Peasant Army and their descendants when visiting Naju.

헛개나무(Hovenia dulcis var. koreana) 과병 열수추출분획물의 간보호 및 혈중 알콜 저하 작용

나천수,정남철,양규환,김세현,정하숙,동미숙 대한약학회 2004 약학회지 Vol.48 No.1

Hovenia dulcis which is distributed in Korea, China and Japan is known to show hepatoprotctive effect and reduce the acute alcohol toxicity. In this study, the hepatoprotective effect against the chemically induced experimental liver injury models and lowering effect of blood alcohol level in animal models acutely administered alcohol by the peduncle extracts of Hovenia dulcis var. koreana were investigated. HdfHW-1, and HdfM-1 which are the extracts of fruit peduncles and young branches with hot water or 70% methanol and followed with 100% methanol, were significantly reduced the $CCl_4$ or D-galactosamine/LPS induced damage in sliced liver. The hot water or methanol extracts of fruit peduncle protected dose-dependently against $CCl_4$ induced toxicity in primary hepatocyte culture and particularly, the amount of LDH release was reduced to the control level at 500 $\mu\textrm{g}$/ml of hot water extracts. HdfHW-1 also decreased the hepatotoxicity induced by $CCl_4$ in rats. The active components of HdfHW-1 seemed to be high molecular weights because 0.2 M NaCl HdfHW-1 fraction was the most effective among NaCl fractions of HdfHW-1 eluted with various concentrations of NaCl on DEAE 650C column chromatography. HdfM and HdfHW were significantly reduced the levels of blood alcohol in rats and mice administered 40% alcohol. These results indicated that the hot water or methanol extracts of fruit peduncle of Hovenia dulcis var. koreana have hepatoprotective effect and may be reduce alcohol toxicity.

금강산 기행 소감 - 국가전문행정연수원 제 21 세기 고급간부과정 -

나천수 대한지방행정공제회 2001 地方行政 Vol.50 No.574

N/A

신숙주, 충 · 불충을 다시보다

나천수(羅千洙) 원광대학교 원불교사상연구원 2020 원불교사상과 종교문화 Vol.84 No.-

신숙주는 세간 사람들에게 변절자의 대명사처럼 인식되고, 그동안 우리나라 소설이나 TV 드라마에서도 단종을 지지하지 않았다는 이유로 변절자로 묘사되었다. 그 이유는 남효온이 지은「육신전」에서 단종의 편에 서지 않았다는 말 한마디 때문이다. 또 남효온의「육신전」을 단초로 일제 강점기 이후부터 조선인의 혼을 폄하하는 차원에서 신숙주를 변절의 대명사로 소설, 영화, TV드라마에서 등장케 하였다. 과연 신숙주는 변절자인지 궁금하다. 논자는 최초 신숙주를 폄하하는 글을 쓴 남효온의『추강집』 속에 수록된「육신전」을 살펴보던 중에, 1576년 선조 때 발견되어 경연에서 육신전에 대한 잘못된 점을 선조가 열거하면서 질타하였는데, 현재 세간에서 볼 수 있는『추강집』에는 1577년에 간행된 것으로 이 재간본에는 선조가 잘못되었다고 지적한 부분이 모두 삭제 된 점을 발견하게 되었다. 선조가 발견한 추강집의 오류는 초간본에서의 오류를 지적한 것이다. 그리하여 선조가 지적한 부분을 모두 개작하여 재간된 간행본이 현재 세간에 발견된『추강집』이므로 이를 위작이 아닐까 반문해 보는 것이다. 한편 신숙주의 충의 단면을 살펴볼 수 있는 것은 그가 저술한『해동제국기』라고 논자는 주장한다. 세종의 명을 받아 일본을 다녀온 사행보고서는『세종실록』102권[1443년(세종25년) 10월13일]자 기사에 분명히 ‘일본국(日本國)에 갔던 통신사 변효문(卞孝文)이 돌아와 경상도 옥포(玉浦)에 이르러 치계(馳啓)하기를’ 란 기록으로 보아 사행보고서는 이미 세종 때에 보고한 것이다. 그로부터 28년 후인 성종 때 사행 보고서로 『해동제국기』를 썼다는 말은 맞지 않은 것이다. 또한『 해동제국기』 서문에는 사행 보고서와는 전혀 무관한 내용이 서술되어 있다. 그것은 왕이 지녀야할 덕목을 열거해 놓은 것이다. 그러므로 이 부분에 착안하여 왜『 해동제국기』를 썼느냐에 질문을 하고, 그에 대한 답변을 함으로 신숙주의 충(忠)의 단면을 밝혀 낸 것이다. This paper examines the loyalty of Shin Suk-ju who has been recognized by many as a traitor and has long been described as such in Korean novels or dramas for not supporting King Danjong. This was largely due to『Yuk-Sin-Jeon』 by Nam Hyo-on where he commented that Shin Suk-ju did not stand by King Danjong’s side. Shin Suk-ju became a byword for betrayer as motivated by『Yuk-Sin-Jeon』 and frequently appeared in a novel, movie or TV drama in order to disparage the spirit of the Joseon people. When King Seonjo discovered『Yuk-Sin-Jeon』 in 1576, he criticized its errors at Gyeongyeon. However, it was identified that all the errors King Seonjo pointed out were deleted from『Yuk-Sin-Jeon』 published in 1577, the only publication discovered to the current generation as part of Chu-Gang-Jip. If what was criticized in the first publication were all adapted and re-published, the book can be considered as a forgery. Meanwhile, Shin Suk-ju’s loyalty to the King can be found in his book Haedong Chegukki where he enumerated virtues for a king to keep. According to volume 102 of Sejong Chronicles, it was evident that a private report by Byun Hyo-mun to King Sejong after he came back from Japan was reported during the reign of King Sejong. Therefore, it does not make sense to say Haedong Chegukki was written as a private report 28 years later, during the reign of King Sungjong. Based on these findings, this paper discloses loyal aspect of Shin Suk-ju by reviewing Haedong Chegukki.

정책소개 : 전라남도의 지역정보화 ; 정보화마을의 역사적 의미와 발전방안 -제2 새마을 운동으로 접목

나천수 한국지역정보개발원 (구 자치정보화조합) 2004 지역정보화 Vol.26 No.-

『破閑集 譯註』 소재 詠史詩의 재해석

나천수 고려대학교 역사연구소 2014 사총 Vol.83 No.-

랫드를 이용한 헛개나무과병 열수추출물 투여가 운동에 의한 피로회복과 운동수행능력에 미치는 기전 규명

나천수,김희경,김진범,노현정,엄나나,노혜지,나대승,동미숙,홍철이 대한약학회 2013 약학회지 Vol.57 No.5

The present study investigated the effects of Hovenia Dulcis (HD) fruit extract powder on the improvement of physical activity, especially exercise capacity. Forty mice were divided into 4 groups including normal controls, negative controls, 100 (HD-100) and 200 (HD-200) mg/kg HD fruit extract powder groups for 5-times exercises using treadmill. Nor- mal control did not performed treadmill running but others did 5-times for 10 days. HD fruit extract powders were admin- istrated orally one-times per day for 10 days before treadmill exercise and normal and negative controls were fed with excipient water. After 5-times exercise, blood biochemical analysis showed that aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine phosphokinase (CK) activities and blood lactate concentration were statistically increased in negative controls than in normal controls. They were decreased in HD fruit extract powder groups, compared with negative controls. These results were considered as the effects of HD fruit extract powders on reduced tissue damages during exercise. Other measured indices did not reveal remarkable differences. All together, these results suggest that HD fruit extract powders may enhance the exercise performance by recovering the exercise-fatigue via blood lactate con- centration by reducing blood LDH activity and via reduction of blood CK and AST activity.

오리나무 열수 추출물이 실험적으로 유발된 흰쥐의 위염 및 위궤양에 미치는 영향

나천수,이상범,김진범,정하숙,동미숙 한국생약학회 2012 생약학회지 Vol.43 No.1

Alnus japonica Steud (A. japonica) have long been used in the traditional medicine for gastric disorder, hepatitis and fatty liver in Korea. Antiulcer effects of A. japonica hot water extract (AJ ext) were evaluated by in vitro antibacterial activity against H. pylori, by the inhibitory action against the in vitro gastric H^+/K^+ -ATPase and using rat models of gastric mucosal damage and gastric ulcer induced by HCl-ethanol, indomethacin, and restraint and water-immersion stress. For the determination of antibacterial activity of AJ ext against H. pylori, the activity of urease which released from H. pylori was measured in culture. AJ ext showed weak antibacterial activity against H. pylori with the growth inhibitions of 37% and 61% by adding final concentrations of 500 and 1000 µg/ml culture, respectively at 24 h. To observe the inhibitory activity of AJ ext against the H^+/K^+ -ATPase in hog gastric membrane vesicle, IC50 value of AJ ext was 806.3 µg/ml. Pretreatment of AJ ext (200, 500mg/kg, p.o.) prevented in a dose-dependent manner the acute gastritis in HCl-ethanol model and the formation of gastric ulcer in indomethacin model and restraint and water-immersion stress model. These results suggest that the AJ ext can be used for prevention and treatment of gastric mucosal damage and ulcers induced by various stress.