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Parkinson's Disease 환자의 배뇨장애에 관한 연구
나용길 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2
Parkinson's disease is one of the most common neurologic conditions causing voiding dysfunction. It is supposed that 35% to 75% of patients with Parkinson's disease will have symptoms of neurogenic voiding dysfunction. Carefully performed urodynamic investigation is the key to understanding the pathophysiology of Parkinson's disease and forms the basis for reasonable treatment. We evaluated the 20 cases of Parkinson's disease who were admitted to Chungnam National University Hospital from Aug., 1995 to Nov., 1996. Symptoms of voiding dysfunction were presented in 70% of the patients. The presenting symptoms were urgency and frequency(64%), obstructive symptoms(21%), and mixed irritative and obstructive symptoms(15%). Detrusor hyperreflexia was the most common urodynamic finding(55%), and normal(20%), impaired detrusor contractility(15%), detrusor areflxia(10%) were in order. There was a poor correlation between the parkinsonian patient's urologic symptoms and the urodynamic findings.
나용길,김영수 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
We studied 49 cases of urethral injury, patient who had been admitted to the department of urology, Chugnam National University Hospital from 1995 to 1997. The following results were obtained: 1. Among the 49 patients the age distribution ranged form 11 to 75 years of age with the average being 38.8 years. 2. In most of the cases the injury site was located in the anterior part of the urethra(85.7%) and the cause of injury was the straddle injury(62.3%). complete urethral rupture was common in the posterior urethral injuries while incomplete urethral injury was common in the anterior urethral injuries. 3. In the cases of anterior urethral injury, the group who were managed by initial suprapubic cystostomy developed urethral stricture in 92.3% of the patients. Among the 12 cases of urethral stricture, eight were shown to have a complete obstruction of the urethra by concomitant retrograde and voiding cystourethrography. Therefore more aggravative management i.e., primary realignment, is needed in cases of complete rupture in anterior urethral injuries.
방광암 환자에서 염색체 이상이 예후에 미치는 영향에 대한 세포유전학적 연구
나용길,임재성,윤율로,설종구 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
Bladder cancer is the most common type of urinary cancer in Korea. Usually it has an unpredictable natural history with respect to tumor invasion and recurrence. The cytogenetic results and genetic alterations of bladder cancer are thought to be closely related to cancer promotion and progression. To predict the possible relationship among them, we performed the cytogenetic analysis in the bladder cancer patients. The specimens of the 32 patients who underwent operations for the bladder cancer were obtained and cultured. Of them 15 cases were cytogenetically abnormal. There were wide variety of structural and numerical chromosomal aberrations. The most frequently affected chromosomes were 4, 8, 9 and 19 as determined by karyotyping. In our study, as in other studies the more the genes were hyperdiploidy and the more the genetic aberrations were complex, and the cancer was more invasive and the cancer grade was higher. There was frequent loss on chromosome 4, 9, 19 and the appearance of marker chromosomes. Although most amplifications and deletions have been previously described in the literature, our study showed some intriguing and uncommon regions, different from those found in past studies.
Portable Diode Laser와 Fiberoptic Delivery System을 이용한 전립선비대증의 치료
나용길 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1
Interstitial laser coagulation (ILC) therapy which coagulates prostate tissue is a new and promissing method of treatment for symptomatic benign prostatic hyperplasia (BPH) patients. We studied the clinical efficacy and safety of ILC using a diode laser. A total of 15 patients with symptomatic BPH underwent interstitial laser coagulation by portable diode laser and a fiberoptic delivery system. Voiding outcomes, including international prostate symptom scores (IPSS), peak urinary flow rates, and prostate volume were measured by time, and immediate and short-term (3 months)complications were assessed. Epidural anesthesia was performed in all patients. At 3 months, there was as 64.9% improvement is IPSS (25.9 to 9.1, P<0.05) and a 48.2% decrease in prostate volume (46.2 to 23.9 gm, P<0.05). There were no intraoperative complications. Postoperatively, four patients had tansient hematuria and two had transient urinary retention. Our results show that interstitial laser coagulation by diode laser appears to be a single, safe and efficacious procedure for the treatment of symptomatic BPH. I n addition, it is hoped that this will reduce the postoperative dyuria that a significant proportion of men complan of following endoscopic laser coagulation or vaporization of the prostatic urethral lumen.