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추정된 모수를 사용한 CCC-r 관리도에서 관리상태의 성능
김재연,김민지,이재헌,Kim, Jaeyeon,Kim, Minji,Lee, Jaeheon 한국통계학회 2018 응용통계연구 Vol.31 No.4
CCC-r 관리도는 고품질공정에서 공정불량률을 관리하는 경우 매우 효율적이라고 알려져 있다. 이 관리도를 사용할 때 관리상태의 공정모수는 일반적으로 알려져 있지 않기 때문에 제1국면의 표본을 추출하여 이를 추정해야 한다. 제2국면에서 관리도의 성능은 제1국면에서 추정한 모수와 관리한계에 영향을 받기 때문에, 추정 오차의 영향을 살펴보는 것은 중요하다. 이 논문에서는 일반적으로 많이 사용하는 평균런길이의 평균(average of average run length) 이외에 평균런길이의 표준편차(standard deviation of average run length)를 사용하여 CCC-r 관리도의 관리상태의 성능을 평가하였다. 그 결과 CCC-r 관리도에서 안정적인 관리상태의 성능을 유지하기 위해서는 이전에 권장하던 제1국면의 표본 크기보다 훨씬 더 큰 표본이 필요하다는 사실을 알 수 있었다. The CCC-r chart is more effective than traditional attribute control charts for monitoring high-quality processes. In-control process parameters are typically unknown and should be estimated when implementing a CCC-r chart. Phase II control chart performance can deteriorate due to the effect of the estimation error. In this paper, we used the standard deviation of average run length (ARL) as well as the average of ARL to quantify the between-practitioner variability in the CCC-r chart performance. The results indicate that the CCC-r chart requires larger Phase I data than previously recommended in the literature in order to have consistent chart in-control performance among practitioners.
김재연,권남우,조용범,정소희,이문순 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.10
Background : As a part of ongoing research to elucidate and characterize anti-cancer nutraceuticals, extracts from many kinds of medicinal plants were tested for their ability to cytotoxicity on cancer cells so far. Datura stramonium is one of the plants known to contain various alkaloids such as hyoscyamine, scopolamine, atropine etc. Traditionally, it has been used as an analgesic, antispasmodic, and central nervous stimulant. Leaves are also known to be effective against asthma, cough, and chronic bronchitis. In this study, cytotoxicity of extracts from D. stramonium on human cancer cell lines A549 (lung), and HepG2 (liver) were evaluated and compared. Methods and Results : The extract was diluted with DMSO in the form of 10, 50, 250, 1,000 μg/ml for final concentration series respectively. The cell viabilities were examined by MTT assay. On HepG2 cell line, extracts of D. stramonium showed dramatic dose-dependent cytotoxicity on 10, 50, 250, 1,000 ㎍/㎖ concentrations series as 88.16%, 78.55%, 55.57%, 23.06% cell viability respectively. On A549 cell line, likewise, same concentration series showed a dose-dependent cytotoxic effect as 96.49%, 96.12%, 68.54%, 20.26% cell viability respectively. On A549 cell line, there was no difference in effect between 10 ㎍/㎖ and 50 ㎍/㎖. Conclusion : Above results, high concentrations of extracts are effective on two cancer cell lines. These results are expected to be used on further studies about the anticancer activity of D. stramonium as basic data. In order to confirm the anticancer effect of D. stramonium, it is anticipated that additional tests will be required to confirm the apoptosis assay and related protein expression.