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김양수,허준행 한국수자원학회 1993 물과 미래(한국수자원학회지) Vol.26 No.4
본 연구에서는 우리나라 강우자료에 대한 분리효과를 검토하였다. 2변수 대수정규분포, 3변수 대수정규분포등, TYPE-극치분포, 2변수 Gamma 분포, 3변수 Gamma 분포, Log-Pearson Type-분포, GEV분포 등 7개 분포함수를 선정하고, Monte C미개 실험을 이용하여 과거 강우기록 자료로부터 얻은 왜곡도의 평균과 표준편차와 각 분포형들로부터 모의된 왜곡도의 평균과 표준편차와 차이를 분석하였다. 그 결과 우리나라 강우자료는 3변수 Gamma 분포를 제외한 나머지 6개 분포형에서 분리현상을 보였다. This study focuses on the separation effect analysis of rainfall data for 2-parameter log-normal, 3-parameter log-normal, type-extreme value, 2-parameter gamma, 3-parameter gamma, log-Pearson type-III, and general extreme value distribution functions. Difference in the relationship between the mean and standard deviation of skewness for historical data and relations derived from 7 distribution functions are analyzed suing the Monte Carlo experiment. The results show that rainfall data has the separation effect for 6 distribution functions except 3-parameter gamma distribution function.
김양수 철도전문대학교 2004 論文集 Vol.19 No.-
In the study on the performance improvement of clamp for overhead contact-line come to a conclusion. First, analysis of conformation of revolution clip of electric car line shows that external structure is not proper. Second, analysis of material of revolution clip of electric car line shows that AI bronze casting is not proper. Therefore, additional research is needed concerning Fracture toughness test, however, this study suggested two methods. (1) Structure revision is needed to preventing concentration of tightening direction of bolt when electric car line connected. (2) Stronger and lighter material replacement of revolution clip of electric car line is needed.
관해된 급성 골수성 백혈병 환자의 말초 혈액 단핵구로 부터 수지상 세포 분화 유도 및 자가 T 림프구 활성화 유도
김양수 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1
Background and purposes: Evidences for the expression of immunogenecity of AML blast cells are supported by graft versus leukemic reaction, the effect of donor lymphocyte transfusion and in vitro studies with cytotoxic T cell. Dendritic cells (DCs) are important antigen presenting cells in the development of antileukemic T cell cytotoxic reponses. The purpose of this study was to analyze the immunophenotype of dendritic cells cultured from peripheral blood mononuclear cells of AML patients in complete remission and to evaluate whether this immunomodulated DC evoked cytotoxic T cells are capable to kill the leukemic blast or not. Methods: Peripheral blood was obtained from 6 patients of AML in complete remission and 2 healthy controls(HC). Dendritic cell were established from monocyte by culturing in the presence of GM-CSF, Flt-3 ligand. TNF-a, and IL-4 for 8 days. At day 8, cell number was counted and expression of surface marker typical for DCs was analyzed morphologically. The immunophenotypic feature of DCs such as CD1a. CD83, and CD86 was anlayzed by flow cytometry. Thereafter in same day, day 8, DCs were incubated with lysate of leukemic blast and cultured with autologous lymphocyte, because DCs were potent stimulators in an allogenic mixed lymphocyte reaction(MLR). Cytotoxicity against autologouse blast cells was measured by PKH67 assay. Results: After 8 days of culture, cells from all 8 samples exhibited morphological and immunophenotypic features of DCs including expression of CDla, CD83, and CD86. There was no difference in expression of surface marker by DC from AML patients and healthy control. Of 6 samples, 2 were analyzed as an effective stimulator in the autologous MLR and induced antileukemic cytotoxicity. At an effector: target -ration of over 10: 1(and 20: 1) lymphoyte from two patients stimulated with DC pulsed with blast lysates killed about 40-80 % of autologouse blast. Conclusion: Dendritic cell can be generated in AML patients especially during hematopoietic regeneration following chemotherapy. This study indicated that dendritic cells with enhanced antigenecity can be generated from monouclear cell of AML in CR, that these cells can effectively prime autologous cytotoxic T cell in vitro, and that they may be used as potential vaccines in the immunotherapy or therapeutic strategy for minimal residual disease of AML