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김성대,Kim, Seong-Dae 대한산업안전협회 2012 안전기술 Vol.172 No.-
R&P코리아는 지난 1983년 글로벌 제약그룹인 미국의 알피쉐러사(R.P.Scherer Cooperation)와 대웅제약(주)이 합자해 설립한 국내 유일의 연진캡슐 전문 위 수탁 회사다. 세계 제약업계에서 독보적인 위치에 올라 있는 알피쉐러의 오리지널 기술력이 뒷받침되다보니 이곳 제품의 품질은 그 우수성이 남다르다. 때문에 우리나라에 진출한 대부분의 외국 제약사들은 물론 국내의 많은 제약사들도 이곳과 거래를 하고 있다. 허나 이곳은 이런 성공에도 불구하고 신기술 개발과 경쟁력 제고를 위한 노력을 멈추지 않고 있다. 그 결과 매년 10% 이상의 성장을 지속하고 있으며, 건강기능 식품 등을 생산하는 헬스케어토탈 기업으로 거침없이 나아가고 있다. 이같은 R&P코리아의 끊임없는 성장에는 우수한 안전관리가 큰 영향을 미치고 있다. 빈틈없는 공정 안전관리를 통해 최고의 생산성과 품질력을 유지하고 있다는 게 이곳 임직원들의 설명. 세심한 안전활동으로 R&P코리아의 성공신화를 이끌고 있는 조경민 과장을 만나봤다.
대사증후군 백서모델에서 음경해면체의 발기능 및 조직학적 변화
김성대,조수연,손동완,이동섭,정문수,김두배,김효신,조용현,박철휘,김세웅 대한남성과학회 2008 The World Journal of Men's Health Vol.26 No.4
Purpose: We evaluated the changes of the erectile function and histology of the corpus cavernosum in a rat model of metabolic syndrome. Materials and Methods: We used male spontaneous hypertensive rats (SHRs) as an experimental group (n=6) and Wistar-Kyoto rats as a control group (n=6). The SHRs were fed with a high fat diet, but the Wistar-Kyoto rats were fed with a normal fat diet for 12 weeks. All the groups were then checked for body weight and various biochemiclal parameters. To investigate penile erection, the intracavernosal pressure (ICP), mean arterial pressure (MAP) and cGMP level of the corpus cavernosum were recorded for all the groups. Serial sections of the penis were used to perform Masson's trichrome staining and immunohistochemistry for determining the TGF-β1 expression. Results: We confirmed that metabolic syndrome was induced in the experimental group by the significant difference of the various biochemical parameters. (ED note: For the results of erectile function? This wasn’t clear.)As a result of erectile function, the ICP/MAP ratios were checked as 51.0±7.5% and 31.0±5.5%, respectively, for the control and experimental groups. So the ICP/MAP ratio of the latter was markedly decreased compared with the former and the cGMP level of the corpus cavernosum was the same for both groups. On Masson's trichrome staining, the number of smooth muscle cell was decreased and the collagen fibers with an irregular, distorted arrangement were increased in the experimental group. The immunoreactivity for TGF-β1 tended to increase in the experimental group. These histological findings revealed that fibrosis of the corpus cavernosum occurred in the experimental group. Conclusions: Our results demonstrate that metabolic syndrome is harmful to erectile function and it leads to histological changes of the corpus cavernosum according to a rat model of metabolic syndrome
김성대,Kim, Seong-Dae 대한산업안전협회 2012 안전기술 Vol.169 No.-
일생활에 꼭 필요한 것을 꼽으라 하면 시람에 따라 다르겠다. 어떤이는 물이라 할 것이고, 어떤이는 교통수단을 말릴 것이다. 또 어떤이는 전기라고 말하는 이도 있을 것이다. 모두 틀린말은 아니다. 우리 생활에 꼭 필요한 전기. 하지만 우리는 대기중의 공기처럼 자연스럽게 사용하고 있을 뿐 우리가 최종사용자로서 사용하기까지 얼마나 많은 이들이 노력하고 있는지는 생각해 보고 있지 않은 듯하다. 아무도 알아주지 않아도 국민을 위해 묵묵히 전력을 공급하고 있는 100년 전통의 명품 전력회사인 '한국전력공사 대전충남본부'를 찾아가 봤다.
김성대,김선욱,윤병일,하유신,김세웅,조용현,손동완 대한남성과학회 2013 The World Journal of Men's Health Vol.31 No.1
Purpose: We evaluated adult patients with acute epididymitis to identify the frequency of actual sexual contacts and the causative organism, and compared clinical examinations, degrees of manifested symptoms, and radiological test results. Materials and Methods: We reviewed the medical records of 65 patients older than 18 years presenting with acute epididymitis who had been treated between 2002 and 2011. Scrotal ultrasonography, urinalysis, and urine culture were performed to diagnose the acute epididymitis. Patients were divided into negative (n=45) and positive (n=20) urine culture groups. Then the latter groups were subdivided into a sexually transmitted organism (STO) culture group (n=13) and a non-STO (n=7) culture group. Data on any history of sexual contact, scrotal pain and tenderness, symptoms of urethritis (discharge, dysuria, urethral burning, or irritation), and lower urinary tract symptoms (dysuria, frequency, and urgency of urination) were obtained from all of the subjects. Results: Patients in the positive urine culture group were significantly younger than those in the other group (p=0.224) and were more likely to have a history of sexual contact at least two weeks prior to onset of epididymitis (p=0.012). They had also a significantly enlarged epididymal head and significantly more severe complaints of pain or tenderness than those of latter group (p=0.348, p=0.288). However, the difference in these measures between the STO and non-STO group was not significant, except in the case of age (p=0.044). Conclusions: Patients of the positive urine culture group with acute epididymitis were significantly younger and more sexually active than the others. They also had severe pain or tenderness and an enlarged epididymal head. There was a close association between clinical symptoms, a positive urine culture, and ultrasonographic findings.