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Ziprasidone의 안전성과 유효성에 관한 국내 시판 후 조사 연구
김성년,김의태,황재연,권준수 대한정신약물학회 2011 대한정신약물학회지 Vol.22 No.2
Objective The aim of this study was to observe the safety and efficacy of ziprasidone in the usual care setting in patients with schizophrenia or acute manic or mixed episodes associated with bipolar disorder. Methods A total of 3,391 patients who were treated with ziprasidone were enrolled from 108 centers in Korea. Differences in the clinical global impression of severity and clinical global impression of improvement (CGI-I) were measured after 8±1 weeks administration of ziprasidone. Adverse events were observed in all subjects who were administered ziprasidone at least once. In 330 patients, the change of weight was evaluated. Results Ziprasidone was effective for most of schizophrenia and acute manic or mixed episodes associated with bipolar disorder patients. CGI-I score was improved in 84.8% of PP subjects. Of the subjects who did not complete the study, sixty-four (1.9%) subjects discontinued treatment due to adverse events. The most common adverse events were akathisia, somnolence,extrapyramidal symptoms and insomnia. In total, 6 serious adverse events were reported in 2 subjects, including psychotic disorder and suicidal attempt. Mean 0.9 kg of weight loss was observed. Conclusion ziprasidone was effective, safe and generally well tolerated for schizophrenia or acute manic or mixed episodes associated with bipolar disorder patients in Korea. 본 연구는 3,391명의 환자에서 ziprasidone의 시판 후 조사를 통해 실제 임상 상황에서의 정신분열병, 양극성 장애와 관련된 급성 조증 혹은 혼재 삽화 치료에 대한 유효성과 안전성을 관찰하였다. 한 번 이상 연구 약물을 복용한 모든 환자에서 82.2%의 임상적 호전이 관찰되었다. 평균 75.8일의 복용기간 동안 평균 0.9 kg의 유의한 체중 감소가 나타났으며, 이 외 가장 흔한 유해사례는 정좌불능, 졸림, 추체외로 증상과 불면증이었다. 중대한 유해사례는 2명의 환자에서 발생하였는데, 그 중 1명에서 정신증적 증상과 자살 시도가 있었다. 결론적으로 국내에서 ziprasidone은 실제의 일반적인 임상 상황에서 정신분열병, 양극성 장애와 관련된 급성 조증 혹은 혼재 삽화 치료에 안전하고 효과적으로 사용될 수 있다고 판단된다.
脚筋力과 體力要因과의 相關 : 男子 高等學生을 對象으로
金性年,李永雄 慶尙大學校 1985 論文集 Vol.24 No.2
The purpose of this study is to give a help to an efficient guiding principles of the class for physical education and in profesional physical fitness, comparing and analyzing the correlation bet ween leg strength and the factors of high-school students. The factors of the measured physical fitness were leg strength test, 50m sprint, 100m sprint, 1,000m distance run, sit-ups, dynamic balance and static balance. The height, weight, chest girth, sitting height of the boys as a physical factors were measured. The results of measurement and analysis were as the following: 1. There were high correlation between leg strength and 50m, 100m sprint. 2. There was high correlation between leg strength and 1,000m distance run. 3. There was high .correlation between leg strength and sit-ups, 4. There was low correlation between leg strength and dynamic balance. 5. There was very low .correlation between leg strength and static balance. 6. There was high correlation between leg strength and each item of the factors of physiques.