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사후 가토에서 Lithium의 혈중농도와 골수농도의 비교
김상도,오승상,배학연,오금탁,홍순표,조건국,양성훈 朝鮮大學校 附設 醫學硏究所 1988 The Medical Journal of Chosun University Vol.13 No.1
Blood is the usual specimen analyzed when concentration of a certain toxic chemical is to be investigated. However it is sometimes necessary to resort to other tissues if a satisfactory post mortem blood sample is unavailable or contaminated or damaged. Bone marrow is one of the tissues which may be useful in determining drug concentration, because it is highly vascularized and well protected within the bone. so, recently bone marrow has been examined as a specimen in toxicological studies. The post-mortem blood and bone marrow lithium concentrations were measured for the purpose of determining the relationship between lithium concentrations in both tissues. The rabbits which were given lithium carbonate in doses of 53, 106 and 159 (equivalent of lithium 10,20 and 30)㎎/㎏ were autopsied 0.5, 8 and 24 hours after sacrifice. The results were as follows. The overall mean bone marrow blood lithium ratio was 0.514±0.084. Bone marrow lithium concentration versus blood lithium concentration showed a linear relationship. The correlation coefficient was 0.994. This study showed that the blood lithium concentration could be estimated from the bone marrow concentrations of it.